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Index > Protein center > TK2(Gene name) > Human
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  • TK2 (Gene name),
  • Thymidine kinase 2, mitochondrial (Protein name ),  KITM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    TK2;
    Protein name:
    Thymidine kinase 2, mitochondrial;
    Alternative:
    Mt-TK;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine. Also phosphorylates anti-viral and anti-cancer nucleoside analogs.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    265
    Sequence:
    50:
    MLLWPLRGWA | ARALRCFGPG | SRGSPASGPG | PRRVQRRAWP | PDKEQEKEKK | 
    100:
    SVICVEGNIA | SGKTTCLEFF | SNATDVEVLT | EPVSKWRNVR | GHNPLGLMYH | 
    150:
    DASRWGLTLQ | TYVQLTMLDR | HTRPQVSSVR | LMERSIHSAR | YIFVENLYRS | 
    200:
    GKMPEVDYVV | LSEWFDWILR | NMDVSVDLIV | YLRTNPETCY | QRLKKRCREE | 
    250:
    EKVIPLEYLE | AIHHLHEEWL | IKGSLFPMAA | PVLVIEADHH | MERMLELFEQ | 
    265:
    NRDRILTPEN | RKHCP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Thymidine kinase 2, mitochondrial
    Cat.:
    E2367h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Thymidine kinase 2, mitochondrial
    Cat.:
    E2367m
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Thymidine kinase 2, mitochondrial
    Cat.:
    U2367h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Thymidine kinase 2, mitochondrial
    Cat.:
    U2367m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Thymidine kinase 2, mitochondrial
    Cat.:
    P2367Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Thymidine kinase 2, mitochondrial
    Cat.:
    P2367Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Thymidine kinase 2, mitochondrial
    Monoclonal Antibody for Human Thymidine kinase 2, mitochondrial
    Protein for Human Thymidine kinase 2, mitochondrial
    Protein for Human Thymidine kinase 2, mitochondrial

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2."
      Johansson M. , Karlsson A.
      J. Biol. Chem.272:8454-8458(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
      tissue: Liver.
    2. 2.
      "Human thymidine kinase 2: molecular cloning and characterisation of the enzyme activity with antiviral and cytostatic nucleoside substrates."
      Wang L. , Munch-Petersen B. , Herrstroem Sjoeberg A. , Hellman U. , Bergman T. , Joernvall H. , Eriksson S.
      FEBS Lett.443:170-174(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG);PROTEIN SEQUENCE OF 34-61 (ISOFORM LONG);CHARACTERIZATION
      tissue: Brain.
    3. 3.
      Wang L.
      Submitted (2002-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4 AND 5)
      tissue: Brain.
      tissue: Testis.
    5. 5.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Mutant mitochondrial thymidine kinase in mitochondrial DNA depletion myopathy."
      Saada A. , Shaag A. , Mandel H. , Nevo Y. , Eriksson S. , Elpeleg O.
      Nat. Genet.29:342-344(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MTDPS2 ASN-121 AND ASN-212
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MTDPS2 MET-53; MET-108 AND ASN-121
    9. 9.
      "Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes."
      Wang L. , Limongelli A. , Vila M.R. , Carrara F. , Zeviani M. , Eriksson S.
      Mol. Genet. Metab.84:75-82(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MTDPS2 MET-108 AND LYS-192;CHARACTERIZATION OF VARIANTS MTDPS2 MET-108 AND LYS-192
    10. 10.
      "Novel mutations in the thymidine kinase 2 gene (TK2) associated with fatal mitochondrial myopathy and mitochondrial DNA depletion."
      Tulinius M. , Moslemi A.-R. , Darin N. , Holme E. , Oldfors A.
      Neuromuscul. Disord.15:412-415(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MTDPS2 MET-64 AND TRP-183
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