Gene name:
Map1lc3b (Map1alc3;Map1lc3) ;
Protein name:
Microtubule-associated proteins 1A/1B light chain 3B ;
Alternative:
Autophagy-related ubiquitin-like modifier LC3 B ;Autophagy-related protein LC3 B ;MAP1A/MAP1B light chain 3 B (MAP1A/MAP1B LC3 B) ;MAP1 light chain 3-like protein 2 ;Microtubule-associated protein 1 light chain 3 beta ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts at microtubules with CABP1 (via EF-hands 1 and 2) but not with calmodulin. A calcium-dependent binding site is located at the C-terminus while a calcium-independent binding site is located at the N-terminus. Interacts with FYCO1 (via C-terminus).
Function:
Probably involved in formation of autophagosomal vacuoles (autophagosomes).
Subcellular Location:
Cytoplasm
cytoskeleton
Endomembrane system
Lipid-anchor
Cytoplasmic vesicle
autophagosome membrane
Lipid-anchor
LC3-II binds to the autophagic membranes.
Protein Attributes:
50:
MPSEKTFKQR | RSFEQRVEDV | RLIREQHPTK | IPVIIERYKG | EKQLPVLDKT |
100:
KFLVPDHVNM | SELIKIIRRR | LQLNANQAFF | LLVNGHSMVS | VSTPISEVYE |
142:
SERDEDGFLY | MVYASQETFG | TALAVTYMSA | LKATATGREP | CL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Bovine
Human
Mouse
ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
ELISA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
CLIA Kit for Rat Microtubule-associated proteins 1A/1B light chain 3B
Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Polyclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Monoclonal Antibody for Rat Microtubule-associated proteins 1A/1B light chain 3B
Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
Protein for Rat Microtubule-associated proteins 1A/1B light chain 3B
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Brain .
2.
"Cloning and characterization of rat lc3 orthologs."
Dang Y.
,
Yu L.
,
Wu J.
,
Pei Y.
Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
Sprague-Dawley .
tissue :
Brain .
3.
"Rattus norvegicus microtubule-associated protein 1 light chain 3 (Map1lc3)."
Zhou G.
,
Dai F.
,
Yu L.
Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
Sprague-Dawley .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Heart .
tissue :
Pituitary .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 31-37;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .
6.
"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing."
Kabeya Y.
,
Mizushima N.
,
Ueno T.
,
Yamamoto A.
,
Kirisako T.
,
Noda T.
,
Kominami E.
,
Ohsumi Y.
,
Yoshimori T.
EMBO J.19:5720-5728(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;CLEAVAGE;MUTAGENESIS OF GLY-120
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
8.
"Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins."
Seidenbecher C.I.
,
Landwehr M.
,
Smalla K.H.
,
Kreutz M.
,
Dieterich D.C.
,
Zuschratter W.
,
Reissner C.
,
Hammarback J.A.
,
Bockers T.M.
,
Gundelfinger E.D.
,
Kreutz M.R.
J. Mol. Biol.336:957-970(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH CABP1
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE BY ATG4B;MUTAGENESIS OF GLN-116; PHE-119 AND GLY-120
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : CLEAVAGE BY ATG4B
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 1-120
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1-124 IN COMPLEX WITH ATG4B