MX1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comMX1 Polyclonal Antibody for Human(Homo sapiens)

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MX1 (Gene name),

Interferon-induced GTP-binding protein Mx1 (Protein name ), MX1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

MX1;

Protein name:

Interferon-induced GTP-binding protein Mx1;

Alternative:

Interferon-regulated resistance GTP-binding protein MxA;Interferon-induced protein p78(IFI-78K);Myxovirus resistance protein 1;Myxoma resistance protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TRPC1, TRPC3, TRPC4, TRPC5, TRPC6 and TRPC7.

Function:

May regulate the calcium channel activity of TRPCs. Shows activity against influenza virus and VSV, a rhabdovirus.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

662

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

662:

TQARRRLAQF | PG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

147150

UniGene:

Hs.517307

String:

P20591

SMR:

P20591

KEGG:

hsa:4599

STRING:

9606.ENSP00000381599

Pfam:

PF01031

Uniprot:

P20591

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928m

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928b

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928d

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928r

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928h

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ELISA Kit for Human Interferon-induced GTP-binding protein Mx1

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E2928p

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96T

CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928p

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CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928r

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CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928m

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96T

CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928b

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96T

CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928h

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CLIA Kit for Human Interferon-induced GTP-binding protein Mx1

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U2928d

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Polyclonal Antibody for Human Interferon-induced GTP-binding protein Mx1

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P2928Rb-h

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Polyclonal Antibody for Human Interferon-induced GTP-binding protein Mx1

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P2928Rb-m

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Polyclonal Antibody for Human Interferon-induced GTP-binding protein Mx1

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P2928Rb-r

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Monoclonal Antibody for Human Interferon-induced GTP-binding protein Mx1

Protein for Human Interferon-induced GTP-binding protein Mx1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"cDNA structures and regulation of two interferon-induced human Mx proteins."
Aebi M. , Faeh J. , Hurt N. , Samuel C.E. , Thomis D. , Bazzigher L. , Pavlovic J. , Haller O. , Staeheli P.
Mol. Cell. Biol.9:5062-5072(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-379
2.

"Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter."
Horisberger M.A. , McMaster G.K. , Zeller H. , Wathelet M.G. , Dellis J. , Content J.
J. Virol.64:1171-1181(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ILE-379
3.

"Structure and polymorphism of the human gene for the interferon-induced p78 protein (MX1): evidence of association with alopecia areata in the Down syndrome region."
Tazi-Ahnini R. , di Giovine F.S. , McDonagh A.J. , Messenger A.G. , Amadou C. , Cox A. , Duff G.W. , Cork M.J.
Hum. Genet.106:639-645(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-379;POSSIBLE INVOLVEMENT IN ALLOPECIA AREATA
4.

"Herpes simplex virus-1 induces expression of a novel MxA isoform that enhances viral replication."
Ku C.C. , Che X.B. , Reichelt M. , Rajamani J. , Schaap-Nutt A. , Huang K.J. , Sommer M.H. , Chen Y.S. , Chen Y.Y. , Arvin A.M.
Immunol. Cell Biol.89:173-182(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION (ISOFORM 2);ALTERNATIVE SPLICING
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-379
6.

"The DNA sequence of human chromosome 21."
Hattori M. , Fujiyama A. , Taylor T.D. , Watanabe H. , Yada T. , Park H.-S. , Toyoda A. , Ishii K. , Totoki Y. , Choi D.-K. , Groner Y. , Soeda E. , Ohki M. , Takagi T. , Sakaki Y. , Taudien S. , Blechschmidt K. , Polley A. , more...
Nature405:311-319(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ILE-379
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ILE-379
tissue: B-cell.
tissue: Uterus.
9.

Bienvenut W.V. , Gao M. , Leug H.
Submitted (2009-07) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-10; 84-97 AND 442-481;ACETYLATION AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Prostatic carcinoma.
10.

"Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies."
Horisberger M.A. , Hochkeppel H.K. , Content J.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-57;NUCLEOTIDE SEQUENCE OF 2-124
11.

"Purification and characterization of a human Mx protein."
Weitz G. , Bekisz J. , Zoon K. , Arnheiter H.
J. Interferon Res.9:679-689(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-26
12.

"Inf-induced gene expression analysis in MS patients: Loss of bioavailability can be caused by either binding or neutralizing antibodies."
Narayan K. , Pachner A.R.
Submitted (2002-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 486-569
13.

"Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein."
Pavlovic J. , Zuercher T. , Haller O. , Staeheli P.
J. Virol.64:3370-3375(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RESISTANCE TO INFLUENZA VIRUS AND VSV
14.

"A functional GTP-binding motif is necessary for antiviral activity of Mx proteins."
Pitossi F. , Blank A. , Schroeder A. , Schwarz A. , Huessi P. , Schwemmle M. , Pavlovic J. , Staeheli P.
J. Virol.67:6726-6732(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-81 AND LYS-83
15.

"Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity."
Ponten A. , Sick C. , Weeber M. , Haller O. , Kochs G.
J. Virol.71:2591-2599(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF THR-103
16.

"GTP-bound human MxA protein interacts with the nucleocapsids of Thogoto virus (Orthomyxoviridae)."
Kochs G. , Haller O.
J. Biol. Chem.274:4370-4376(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH THOV NUCLEOPROTEIN
17.

"Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes."
Kochs G. , Janzen C. , Hohenberg H. , Haller O.
Proc. Natl. Acad. Sci. U.S.A.99:3153-3158(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH LACV PROTEIN N;MUTAGENESIS OF GLU-645
18.

"Human MxA protein inhibits the replication of Crimean-Congo hemorrhagic fever virus."
Andersson I. , Bladh L. , Mousavi-Jazi M. , Magnusson K.E. , Lundkvist A. , Haller O. , Mirazimi A.
J. Virol.78:4323-4329(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CCHFV PROTEIN N;MUTAGENESIS OF GLU-645
19.

"Nuclear MxA proteins form a complex with influenza virus NP and inhibit the transcription of the engineered influenza virus genome."
Turan K. , Mibayashi M. , Sugiyama K. , Saito S. , Numajiri A. , Nagata K.
Nucleic Acids Res.32:643-652(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Missorting of LaCrosse virus nucleocapsid protein by the interferon-induced MxA GTPase involves smooth ER membranes."
Reichelt M. , Stertz S. , Krijnse-Locker J. , Haller O. , Kochs G.
Traffic5:772-784(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
21.

"Inhibition of Dugbe nairovirus replication by human MxA protein."
Bridgen A. , Dalrymple D.A. , Weber F. , Elliott R.M.
Virus Res.99:47-50(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
22.

"MxA, a member of the dynamin superfamily, interacts with the ankyrin-like repeat domain of TRPC."
Lussier M.P. , Cayouette S. , Lepage P.K. , Bernier C.L. , Francoeur N. , St-Hilaire M. , Pinard M. , Boulay G.
J. Biol. Chem.280:19393-19400(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH TRPC1; TRPC3; TRPC4; TRPC5; TRPC6 AND TRPC7;MUTAGENESIS OF LYS-83; THR-103 AND LEU-612
23.

"Assay and functional analysis of dynamin-like Mx proteins."
Kochs G. , Reichelt M. , Danino D. , Hinshaw J.E. , Haller O.
Methods Enzymol.404:632-643(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;OLIGOMERIZATION;INTERACTION WITH LACV PROTEIN N
24.

"Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways."
Zhao C. , Denison C. , Huibregtse J.M. , Gygi S.P. , Krug R.M.
Proc. Natl. Acad. Sci. U.S.A.102:10200-10205(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISGYLATION
25.

"Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum."
Stertz S. , Reichelt M. , Krijnse-Locker J. , Mackenzie J. , Simpson J.C. , Haller O. , Kochs G.
J. Interferon Cytokine Res.26:650-660(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
26.

"Expression of the interferon-alpha/beta-inducible bovine Mx1 dynamin interferes with replication of rabies virus."
Leroy M. , Pire G. , Baise E. , Desmecht D.
Neurobiol. Dis.21:515-521(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"Human MxA protein confers resistance to double-stranded RNA viruses of two virus families."
Mundt E.
J. Gen. Virol.88:1319-1323(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"The Mx GTPase family of interferon-induced antiviral proteins."
Haller O. , Stertz S. , Kochs G.
Microbes Infect.9:1636-1643(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;INDUCTION
29.

"GTPase activity is not essential for the interferon-inducible MxA protein to inhibit the replication of hepatitis B virus."
Yu Z. , Wang Z. , Chen J. , Li H. , Lin Z. , Zhang F. , Zhou Y. , Hou J.
Arch. Virol.153:1677-1684(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"Inhibition of a large double-stranded DNA virus by MxA protein."
Netherton C.L. , Simpson J. , Haller O. , Wileman T.E. , Takamatsu H.H. , Monaghan P. , Taylor G.
J. Virol.83:2310-2320(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
31.

"Dynamin-like MxA GTPase: structural insights into oligomerization and implications for antiviral activity."
Haller O. , Gao S. , von der Malsburg A. , Daumke O. , Kochs G.
J. Biol. Chem.285:28419-28424(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON STRUCTURE;DOMAIN GED;DOMAIN MIDDLE
32.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
33.

"Interferon-induced antiviral protein MxA interacts with the cellular RNA helicases UAP56 and URH49."
Wisskirchen C. , Ludersdorfer T.H. , Mueller D.A. , Moritz E. , Pavlovic J.
J. Biol. Chem.286:34743-34751(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH DDX39A AND DDX39B
34.

"Stalk domain of the dynamin-like MxA GTPase protein mediates membrane binding and liposome tubulation via the unstructured L4 loop."
von der Malsburg A. , Abutbul-Ionita I. , Haller O. , Kochs G. , Danino D.
J. Biol. Chem.286:37858-37865(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-554; LYS-555; LYS-556 AND LYS-557
35.

"Human MxA protein: an interferon-induced dynamin-like GTPase with broad antiviral activity."
Haller O. , Kochs G.
J. Interferon Cytokine Res.31:79-87(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
36.

"Interferon-inducible antiviral protein MxA enhances cell death triggered by endoplasmic reticulum stress."
Numajiri Haruki A. , Naito T. , Nishie T. , Saito S. , Nagata K.
J. Interferon Cytokine Res.31:847-856(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH HSPA5
37.

"Structural basis of oligomerization in the stalk region of dynamin-like MxA."
Gao S. , von der Malsburg A. , Paeschke S. , Behlke J. , Haller O. , Kochs G. , Daumke O.
Nature465:502-506(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 366-636;SUBUNIT
38.

"Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral function."
Gao S. , von der Malsburg A. , Dick A. , Faelber K. , Schroder G.F. , Haller O. , Kochs G. , Daumke O.
Immunity35:514-525(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF 33-662;SUBUNIT;MUTAGENESIS OF GLU-632 AND ARG-640

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