Protein name:
Nuclear autoantigenic sperm protein (NASP) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds to linker H1 histones but not to core histones. Also binds to HSP90 in the cytoplasm. This interaction stimulates binding of NASP to HIST1H1T/H1T.
Function:
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA.
Subcellular Location:
Cytoplasm
Nucleus
Protein Attributes:
50:
MAMESTATAA | VAAELVSADK | IEDVPAPSTS | ADKVESLDVD | SEAKKLLGLG |
100:
QKHLVMGDIP | AAVNAFQEAA | SLLGKKYGET | ANECGEAFFF | YGKSLLELAR |
150:
MENGVLGNAL | EGVHVEEEEG | EKTEDESLVE | NNDNIDEEAR | EELREQVYDA |
200:
MGEKEEAKKT | EDKSLAKPET | DKEQDSEMEK | GGREDMDISK | SAEEPQEKVD |
250:
LTLDWLTETS | EEAKGGAAPE | GPNEAEVTSG | KPEQEVPDAE | EEKSVSGTDV |
300:
QEECREKGGQ | EKQGEVIVSI | EEKPKEVSEE | QPVVTLEKQG | TAVEVEAESL |
350:
DPTVKPVDVG | GDEPEEKVVT | SENEAGKAVL | EQLVGQEVPP | AEESPEVTTE |
400:
AAEASAVEAG | SEVSEKPGQE | APVLPKDGAV | NGPSVVGDQT | PIEPQTSIER |
450:
LTETKDGSGL | EEKVRAKLVP | SQEETKLSVE | ESEAAGDGVD | TKVAQGATEK |
500:
SPEDKVQIAA | NEETQEREEQ | MKEGEETEGS | EEDDKENDKT | EEMPNDSVLE |
550:
NKSLQENEEE | EIGNLELAWD | MLDLAKIIFK | RQETKEAQLY | AAQAHLKLGE |
600:
VSVESENYVQ | AVEEFQSCLN | LQEQYLEAHD | RLLAETHYQL | GLAYGYNSQY |
650:
DEAVAQFSKS | IEVIENRMAV | LNEQVKEAEG | SSAEYKKEIE | ELKELLPEIR |
700:
EKIEDAKESQ | RSGNVAELAL | KATLVESSTS | GFTPGGGGSS | VSMIASRKPT |
750:
DGASSSNCVT | DISHLVRKKR | KPEEESPRKD | DAKKAKQEPE | VNGGSGDAVP |
788:
SGNEVSENME | EEAENQAESR | AAVEGTVEAG | ATVESTAC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Rat
Bovine
Mouse
Polyclonal Antibody for Human NASP
Polyclonal Antibody for Human NASP
Polyclonal Antibody for Human NASP
Polyclonal Antibody for Human NASP
Polyclonal Antibody for Human NASP
Monoclonal Antibody for Human NASP
Monoclonal Antibody for Human NASP
Monoclonal Antibody for Human NASP
Monoclonal Antibody for Human NASP
Monoclonal Antibody for Human NASP
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Testis .
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"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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Nat. Genet.36:40-45(2004)
[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-635 (ISOFORM 3)
tissue :
Placenta .
tissue :
Teratocarcinoma .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue :
Eye .
tissue :
Lung .
tissue :
Placenta .
tissue :
Testis .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : HISTONE-BINDING REGIONS
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-451; SER-503 AND SER-726;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S.
,
Ballif B.A.
,
Smogorzewska A.
,
McDonald E.R. III
,
Hurov K.E.
,
Luo J.
,
Bakalarski C.E.
,
Zhao Z.
,
Solimini N.
,
Lerenthal Y.
,
Shiloh Y.
,
Gygi S.P.
,
Elledge S.J.
Science316:1160-1166(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-464;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic kidney .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-244; THR-390; SER-408 AND THR-683;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-503;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-33;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
15.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-127; SER-189; SER-451; THR-490; SER-497 AND SER-503;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-138 AND SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-123; SER-127; SER-189; SER-244; SER-299; SER-321; THR-390; SER-408; SER-421; SER-451; THR-464; THR-477; SER-480; THR-490; SER-497; SER-503; SER-726 AND SER-751;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-138 AND SER-141 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]