PDGFC Polyclonal Antibody for Human(Homo sapiens) | EIAab.comPDGFC Polyclonal Antibody for Human(Homo sapiens)

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Index > Protein center > PDGFC(Gene name) > Human

PDGFC (Gene name),

Platelet-derived growth factor C (Protein name ), PDGFC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PDGFC(UNQ174/PRO200;SCDGF);

Protein name:

Platelet-derived growth factor C(PDGF-C);

Alternative:

Spinal cord-derived growth factor(SCDGF);Fallotein;VEGF-E;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Interacts (via CUB domain) with PLAT (via kringle domain).

Function:

Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.

Subcellular Location:

Cytoplasm Secreted Nucleus Cytoplasmic granule Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.

Protein Attributes:

Sequence length:

345

Sequence:

50:

100:

150:

200:

250:

300:

345:

VTKKYHEVLQ | LRPKTGVRGL | HKSLTDVALE | HHEECDCVCR | GSTGG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9NRA1

KEGG:

hsa:56034

STRING:

9606.ENSP00000274071

UniGene:

Hs.570855

Pfam:

PF00431

String:

Q9NRA1

MIM:

608452

Uniprot:

Q9NRA1

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ELISA Kit for Human PDGF-C

Cat.:

E0528r

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96T

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ELISA Kit for Human PDGF-C

Cat.:

E0528h

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96T

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ELISA Kit for Human PDGF-C

Cat.:

E0528m

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96T

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ELISA Kit for Human PDGF-C

Cat.:

E0528c

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96T

CLIA Kit for Human PDGF-C

Cat.:

U0528c

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96T

CLIA Kit for Human PDGF-C

Cat.:

U0528m

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Packing:

96T

CLIA Kit for Human PDGF-C

Cat.:

U0528h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human PDGF-C

Cat.:

U0528r

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Looking for manual.

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96T

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Polyclonal Antibody for Human PDGF-C

Cat.:

P0528Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PDGF-C

Cat.:

P0528Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human PDGF-C

Cat.:

P0528Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human PDGF-C

Monoclonal Antibody for Human PDGF-C

Protein for Human PDGF-C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract."
Tsai Y.J. , Lee R.K. , Lin S.P. , Chen Y.H.
Biochim. Biophys. Acta1492:196-202(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Uterus.
2.

"A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family."
Hamada T. , Ui-Tei K. , Miyata Y.
FEBS Lett.475:97-102(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION
tissue: Brain.
3.

"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."
Li X. , Ponten A. , Aase K. , Karlsson L. , Abramsson A. , Uutela M. , Backstrom G. , Hellstrom M. , Bostrom H. , Li H. , Soriano P. , Betsholtz C. , Heldin C.H. , Alitalo K. , Ostman A. , Eriksson U.
Nat. Cell Biol.2:302-309(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue: Lung.
4.

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
Gilbertson D.G. , Duff M.E. , West J.W. , Kelly J.D. , Sheppard P.O. , Hofstrand P.D. , Gao Z. , Shoemaker K. , Bukowski T.R. , Moore M. , Feldhaus A.L. , Humes J.M. , Palmer T.E. , Hart C.E.
J. Biol. Chem.276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
5.

"An N-terminally truncated isoform of human PDGF-C regulates the secretion of full-length PDGF-C and is deregulated in renal cell carcinoma."
Zhao J. , Liu Z. , Liu T. , Nilsson S. , Nister M.
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
tissue: Fetal brain.
6.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Prostate.
8.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Testis.
11.

"Chromosomal location, exon structure, and vascular expression patterns of the human PDGFC and PDGFC genes."
Uutela M. , Lauren J. , Bergsten E. , Li X. , Horelli-Kuitunen N. , Eriksson U. , Alitalo K.
Circulation103:2242-2247(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
12.

"PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."
Zwerner J.P. , May W.A.
Oncogene20:626-633(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
13.

"Platelet-derived growth factor-B and -C and active alpha-receptors in medulloblastoma cells."
Andrae J. , Molander C. , Smits A. , Funa K. , Nister M.
Biochem. Biophys. Res. Commun.296:604-611(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
14.

"Characterization of platelet-derived growth factor-C (PDGF-C): expression in normal and tumor cells, biological activity and chromosomal localization."
Dijkmans J. , Xu J. , Masure S. , Dhanaraj S. , Gosiewska A. , Geesin J. , Sprengel J. , Harris S. , Verhasselt P. , Gordon R. , Yon J.
Int. J. Biochem. Cell Biol.34:414-426(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;ALTERNATIVE SPLICING (ISOFORMS 2 AND 3);GLYCOSYLATION;MUTAGENESIS OF CYS-124
15.

"Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines."
Zwerner J.P. , May W.A.
Oncogene21:3847-3854(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
16.

"PDGF-C expression in the developing and normal adult human kidney and in glomerular diseases."
Eitner F. , Ostendorf T. , Kretzler M. , Cohen C.D. , Eriksson U. , Grone H.J. , Floege J.
J. Am. Soc. Nephrol.14:1145-1153(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;INDUCTION
17.

"Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure."
Reigstad L.J. , Sande H.M. , Fluge O. , Bruland O. , Muga A. , Varhaug J.E. , Martinez A. , Lillehaug J.R.
J. Biol. Chem.278:17114-17120(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF SECRETED ACTIVE FORM;SUBUNIT;DISULFIDE BONDS;3D-STRUCTURE MODELING
18.

"PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."
Fang L. , Yan Y. , Komuves L.G. , Yonkovich S. , Sullivan C.M. , Stringer B. , Galbraith S. , Lokker N.A. , Hwang S.S. , Nurden P. , Phillips D.R. , Giese N.A.
Arterioscler. Thromb. Vasc. Biol.24:787-792(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
19.

"Tissue plasminogen activator is a potent activator of PDGF-CC."
Fredriksson L. , Li H. , Fieber C. , Li X. , Eriksson U.
EMBO J.23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PLAT
20.

"Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1."
Midgley V.C. , Khachigian L.M.
J. Biol. Chem.279:40289-40295(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY EGR1
21.

"Structural and functional specificities of PDGF-C and PDGF-D, the novel members of the platelet-derived growth factors family."
Reigstad L.J. , Varhaug J.E. , Lillehaug J.R.
FEBS J.272:5723-5741(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
22.

"Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."
Fredriksson L. , Ehnman M. , Fieber C. , Eriksson U.
J. Biol. Chem.280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PLAT;SUBCELLULAR LOCATION;MUTAGENESIS OF ARG-231; LYS-232 AND ARG-234
23.

"Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts."
Jinnin M. , Ihn H. , Mimura Y. , Asano Y. , Yamane K. , Tamaki K.
J. Cell. Physiol.202:510-517(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
24.

"Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma."
Campbell J.S. , Hughes S.D. , Gilbertson D.G. , Palmer T.E. , Holdren M.S. , Haran A.C. , Odell M.M. , Bauer R.L. , Ren H.P. , Haugen H.S. , Yeh M.M. , Fausto N.
Proc. Natl. Acad. Sci. U.S.A.102:3389-3394(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
25.

"Fibroblast growth factor 2 and transforming growth factor beta1 synergism in human bronchial smooth muscle cell proliferation."
Bosse Y. , Thompson C. , Stankova J. , Rola-Pleszczynski M.
Am. J. Respir. Cell Mol. Biol.34:746-753(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
26.

"Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."
Reigstad L.J. , Martinez A. , Varhaug J.E. , Lillehaug J.R.
Exp. Cell Res.312:782-795(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUMOYLATION
27.

"PDGF-C and -D induced proliferation/migration of human RPE is abolished by inflammatory cytokines."
Li R. , Maminishkis A. , Wang F.E. , Miller S.S.
Invest. Ophthalmol. Vis. Sci.48:5722-5732(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
28.

"Increased expression of platelet-derived growth factor C messenger ribonucleic acid in uterine leiomyomata."
Hwu Y.M. , Li S.H. , Lee R.K. , Tsai Y.H. , Yeh T.S. , Lin S.Y.
Fertil. Steril.89:468-471(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
29.

"Plasmin is the major protease responsible for processing PDGF-C in the vitreous of patients with proliferative vitreoretinopathy."
Lei H. , Velez G. , Hovland P. , Hirose T. , Kazlauskas A.
Invest. Ophthalmol. Vis. Sci.49:42-48(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY PLG

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