Pdgfc Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comPdgfc Polyclonal Antibody for Mouse(Mus musculus)

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Pdgfc (Gene name),

Platelet-derived growth factor C (Protein name ), PDGFC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Pdgfc(Scdgf);

Protein name:

Platelet-derived growth factor C(PDGF-C);

Alternative:

Spinal cord-derived growth factor(SCDGF);Fallotein;VEGF-E;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer; disulfide-linked (By similarity). Interacts (via CUB domain) with PLAT (via kringle domain).

Function:

Potent mitogen and chemoattractant for cells of mesenchymal origin. Binding of this growth factor to its affinity receptor elicits a variety of cellular responses. Appears to be involved in the three stages of wound healing: inflammation, proliferation and remodeling. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. Acts as a specific ligand for alpha platelet-derived growth factor receptor homodimer, and alpha and beta heterodimer. Binding to receptors induces their activation by tyrosine phosphorylation. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintainance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. Seems to be involved in palatogenesis.

Subcellular Location:

Cytoplasm Secreted Nucleus Cytoplasmic granule Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets (By similarity). Membrane associated when bound to receptors.

Protein Attributes:

Sequence length:

345

Sequence:

50:

100:

150:

200:

250:

300:

345:

VTKKYHEVLQ | LRPKTGVKGL | HKSLTDVALE | HHEECDCVCR | GNAGG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.331089

Pfam:

PF00431

String:

Q8CI19

SMR:

Q8CI19

KEGG:

mmu:54635

Uniprot:

Q8CI19

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ELISA Kit for Mouse PDGF-C

Cat.:

E0528r

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96T

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ELISA Kit for Mouse PDGF-C

Cat.:

E0528h

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96T

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ELISA Kit for Mouse PDGF-C

Cat.:

E0528m

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96T

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ELISA Kit for Mouse PDGF-C

Cat.:

E0528c

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96T

CLIA Kit for Mouse PDGF-C

Cat.:

U0528c

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96T

CLIA Kit for Mouse PDGF-C

Cat.:

U0528m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse PDGF-C

Cat.:

U0528h

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Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

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CLIA Kit for Mouse PDGF-C

Cat.:

U0528r

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Looking for manual.

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96T

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Polyclonal Antibody for Mouse PDGF-C

Cat.:

P0528Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse PDGF-C

Cat.:

P0528Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse PDGF-C

Cat.:

P0528Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse PDGF-C

Monoclonal Antibody for Mouse PDGF-C

Protein for Mouse PDGF-C

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"The mouse Pdgfc gene: dynamic expression in embryonic tissues during organogenesis."
Ding H. , Wu X. , Kim I. , Tam P.P. , Koh G.Y. , Nagy A.
Mech. Dev.96:209-213(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE
strain: Swiss Webster / NIH.
2.

"cDNA cloning of fallotein from mouse ovary."
Tsai Y.-J. , Lee R.K.-K. , Chen Y.-H. , Lin S.-P. , Cheng W.T.-K.
Submitted (1999-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Ovary.
3.

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha receptor."
Gao Z. , Hart C. , Piddington C. , Sheppard P. , Shoemaker K. , Gilbertson D. , West J. , O'Hara P.J.
Submitted (2000-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: C57BL/6J.
4.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Cecum.
tissue: Cerebellum.
tissue: Head.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: Czech II.
strain: FVB/N.
tissue: Mammary tumor.
6.

"PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor."
Li X. , Ponten A. , Aase K. , Karlsson L. , Abramsson A. , Uutela M. , Backstrom G. , Hellstrom M. , Bostrom H. , Li H. , Soriano P. , Betsholtz C. , Heldin C.H. , Alitalo K. , Ostman A. , Eriksson U.
Nat. Cell Biol.2:302-309(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;DEVELOPMENTAL STAGE
7.

"Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor."
Gilbertson D.G. , Duff M.E. , West J.W. , Kelly J.D. , Sheppard P.O. , Hofstrand P.D. , Gao Z. , Shoemaker K. , Bukowski T.R. , Moore M. , Feldhaus A.L. , Humes J.M. , Palmer T.E. , Hart C.E.
J. Biol. Chem.276:27406-27414(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;TISSUE SPECIFICITY
8.

"PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors."
Zwerner J.P. , May W.A.
Oncogene20:626-633(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
9.

"Expression analysis of PDGF-C in adult and developing mouse tissues."
Aase K. , Abramsson A. , Karlsson L. , Betsholtz C. , Eriksson U.
Mech. Dev.110:187-191(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
10.

"Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy."
Ponten A. , Li X. , Thoren P. , Aase K. , Sjoblom T. , Ostman A. , Eriksson U.
Am. J. Pathol.163:673-682(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Modulation of PDGF-C and PDGF-D expression during bleomycin-induced lung fibrosis."
Zhuo Y. , Zhang J. , Laboy M. , Lasky J.A.
Am. J. Physiol.286:L182-L188(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY BLEOMYCIN
12.

"PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle."
Fang L. , Yan Y. , Komuves L.G. , Yonkovich S. , Sullivan C.M. , Stringer B. , Galbraith S. , Lokker N.A. , Hwang S.S. , Nurden P. , Phillips D.R. , Giese N.A.
Arterioscler. Thromb. Vasc. Biol.24:787-792(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
13.

"PDGF signaling in cells and mice."
Tallquist M. , Kazlauskas A.
Cytokine Growth Factor Rev.15:205-213(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
14.

"Tissue plasminogen activator is a potent activator of PDGF-CC."
Fredriksson L. , Li H. , Fieber C. , Li X. , Eriksson U.
EMBO J.23:3793-3802(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;ACTIVATION BY PROTEOLYTIC CLEAVAGE
15.

"A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling."
Ding H. , Wu X. , Bostrom H. , Kim I. , Wong N. , Tsoi B. , O'Rourke M. , Koh G.Y. , Soriano P. , Betsholtz C. , Hart T.C. , Marazita M.L. , Field L.L. , Tam P.P. , Nagy A.
Nat. Genet.36:1111-1116(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
16.

"Linkage between elevated PDGF-C expression and myocardial fibrogenesis in coxsackievirus B3-induced chronic myocarditis."
Yang D. , Qiu D.
Eur. Heart J.26:642-643(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION BY COXSACKIEVIRUS B3 INFECTION;DISEASE
17.

"Structural requirements for activation of latent platelet-derived growth factor CC by tissue plasminogen activator."
Fredriksson L. , Ehnman M. , Fieber C. , Eriksson U.
J. Biol. Chem.280:26856-26862(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
18.

"PDGF-C controls proliferation and is down-regulated by retinoic acid in mouse embryonic palatal mesenchymal cells."
Han J. , Xiao Y. , Lin J. , Li Y.
Birth Defects Res. B Dev. Reprod. Toxicol.77:438-444(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY RETINOIC ACID
19.

"Aberrant expression of PDGF ligands and receptors in the tumor prone ovary of follitropin receptor knockout (FORKO) mouse."
Chen X. , Aravindakshan J. , Yang Y. , Tiwari-Pandey R. , Sairam M.R.
Carcinogenesis27:903-915(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION BY GONADOTROPIN
20.

"Nuclear localisation of endogenous SUMO-1-modified PDGF-C in human thyroid tissue and cell lines."
Reigstad L.J. , Martinez A. , Varhaug J.E. , Lillehaug J.R.
Exp. Cell Res.312:782-795(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUMOYLATION
21.

"Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts."
Ingram J.L. , Antao-Menezes A. , Mangum J.B. , Lyght O. , Lee P.J. , Elias J.A. , Bonner J.C.
J. Immunol.177:4141-4148(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION BY IL13
22.

"PDGF-C is a proinflammatory cytokine that mediates renal interstitial fibrosis."
Eitner F. , Bucher E. , van Roeyen C. , Kunter U. , Rong S. , Seikrit C. , Villa L. , Boor P. , Fredriksson L. , Backstrom G. , Eriksson U. , Ostman A. , Floege J. , Ostendorf T.
J. Am. Soc. Nephrol.19:281-289(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE

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