PER1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comPER1 Polyclonal Antibody for Human(Homo sapiens)

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PER1 (Gene name),

Period circadian protein homolog 1 (Protein name ), PER1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

PER1(KIAA0482;PER;RIGUI);

Protein name:

Period circadian protein homolog 1(hPER1);

Alternative:

Circadian pacemaker protein Rigui;Circadian clock protein PERIOD 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1.

Function:

Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation.

Subcellular Location:

Nucleus Cytoplasm Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.

Protein Attributes:

Sequence length:

1290

Sequence:

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1250:

1290:

CEEAQGGAKA | SSSQDLAMEE | EEEGRSSSSP | ALPTAGNCTS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.445534

Pfam:

PF08447

STRING:

9606.ENSP00000314420

SMR:

O15534

KEGG:

hsa:5187

MIM:

602260

String:

O15534

Pfam:

PF12114

Uniprot:

O15534

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ELISA Kit for Human hPER1

Cat.:

E3144h

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96T

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ELISA Kit for Human hPER1

Cat.:

E3144m

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96T

ELISA Kit for Human hPER1

Cat.:

E3144r

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96T

CLIA Kit for Human hPER1

Cat.:

U3144r

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Packing:

96T

CLIA Kit for Human hPER1

Cat.:

U3144h

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MSDS:

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Packing:

96T

CLIA Kit for Human hPER1

Cat.:

U3144m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human hPER1

Cat.:

P3144Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human hPER1

Cat.:

P3144Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human hPER1

Cat.:

P3144Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human hPER1

Protein for Human hPER1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Rigui, a putative mammalian ortholog of the Drosophila period gene."
Sun Z.S. , Albrecht U. , Zhuchenko O. , Bailey J. , Eichele G. , Lee C.C.
Cell90:1003-1011(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING;VARIANT PRO-962
tissue: Heart.
2.

"Circadian oscillation of a mammalian homologue of the Drosophila period gene."
Tei H. , Okamura H. , Shigeyoshi Y. , Fukuhara C. , Ozawa R. , Hirose M. , Sakaki Y.
Nature389:512-516(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT PRO-962
tissue: Brain.
3.

"The human Per1 gene: genomic organization and promoter analysis of the first human orthologue of the Drosophila period gene."
Taruscio D. , Zoraqi G.K. , Falchi M. , Iosi F. , Paradisi S. , Di Fiore B. , Lavia P. , Falbo V.
Gene253:161-170(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-962
4.

"The human and mouse Period1 genes: five well-conserved E-boxes additively contribute to the enhancement of mPer1 transcription."
Hida A. , Koike N. , Hirose M. , Hattori M. , Sakaki Y. , Tei H.
Genomics65:224-233(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-962
5.

"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."
Seki N. , Ohira M. , Nagase T. , Ishikawa K. , Miyajima N. , Nakajima D. , Nomura N. , Ohara O.
DNA Res.4:345-349(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-962
tissue: Brain.
6.

Nagase T. , Kikuno R. , Ohara O.
Submitted (2002-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Corpus callosum.
8.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT PRO-962
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT PRO-962
11.

"Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei."
Shearman L.P. , Zylka M.J. , Weaver D.R. , Kolakowski L.F. Jr. , Reppert S.M.
Neuron19:1261-1269(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
12.

"Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon."
Keesler G.A. , Camacho F. , Guo Y. , Virshup D. , Mondadori C. , Yao Z.
NeuroReport11:951-955(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CSNK1E
13.

"Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2."
Camacho F. , Cilio M. , Guo Y. , Virshup D.M. , Patel K. , Khorkova O. , Styren S. , Morse B. , Yao Z. , Keesler G.A.
FEBS Lett.489:159-165(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CSNK1D
14.

"Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts."
Miyazaki K. , Nagase T. , Mesaki M. , Narukawa J. , Ohara O. , Ishida N.
Biochem. J.380:95-103(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INDUCTION
15.

"SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein."
Shirogane T. , Jin J. , Ang X.L. , Harper J.W.
J. Biol. Chem.280:26863-26872(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BTRC AND FBXW11;PHOSPHORYLATION AT THR-121; SER-122 AND SER-126;UBIQUITINATION;MUTAGENESIS OF 210-SER--THR-213; 714-SER--SER-726 AND 794-PHE--PHE-798
16.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979 AND SER-980;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
17.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
18.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704 AND SER-815;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
19.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
21.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-704;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
22.

"Metabolism and the circadian clock converge."
Eckel-Mahan K. , Sassone-Corsi P.
Physiol. Rev.93:107-135(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
23.

"A meeting of two chronobiological systems: circadian proteins Period1 and BMAL1 modulate the human hair cycle clock."
Al-Nuaimi Y. , Hardman J.A. , Biro T. , Haslam I.S. , Philpott M.P. , Toth B.I. , Farjo N. , Farjo B. , Baier G. , Watson R.E. , Grimaldi B. , Kloepper J.E. , Paus R.
J. Invest. Dermatol.134:610-619(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HAIR GROWTH;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
24.

"Molecular architecture of the mammalian circadian clock."
Partch C.L. , Green C.B. , Takahashi J.S.
Trends Cell Biol.24:90-99(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
25.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-696; SER-985 AND LEU-1060

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