Piezo1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comPiezo1 Polyclonal Antibody for Mouse(Mus musculus)

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Piezo1 (Gene name),

Piezo-type mechanosensitive ion channel component 1 (Protein name ), PIEZ1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Piezo1(Fam38a);

Protein name:

Piezo-type mechanosensitive ion channel component 1;

Alternative:

Protein FAM38A;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Component of mechanosensitive channel required for the mechanosensitive currents. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. Overexpression in multiple cell lines generates robust mechanosensitive cation currents that are non-selective, exhibit a linear current voltage relationship, and are sensitive to ruthenium red and gadolinium.

Subcellular Location:

Endoplasmic reticulum membrane Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

2547

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DRILKLCQDI | FLVRETRELE | LEEELYAKLI | FLYRSPETMI | KWTRERE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.37324

Pfam:

PF12166

Uniprot:

E2JF22

FOR

ELISA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227h

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Packing:

96T

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ELISA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227r

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96T

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ELISA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

E3227m

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96T

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CLIA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

U3227r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 1

Cat.:

P3227Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Piezo-type mechanosensitive ion channel component 1

Protein for Mouse Piezo-type mechanosensitive ion channel component 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels."
Coste B. , Mathur J. , Schmidt M. , Earley T.J. , Ranade S. , Petrus M.J. , Dubin A.E. , Patapoutian A.
Science330:55-60(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
2.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1385 AND SER-1646;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
3.

"Piezo proteins are pore-forming subunits of mechanically activated channels."
Coste B. , Xiao B. , Santos J.S. , Syeda R. , Grandl J. , Spencer K.S. , Kim S.E. , Schmidt M. , Mathur J. , Dubin A.E. , Montal M. , Patapoutian A.
Nature483:176-181(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;HOMOOLIGOMERIZATION
4.

"Multiple clinical forms of dehydrated hereditary stomatocytosis arise from mutations in PIEZO1."
Andolfo I. , Alper S.L. , De Franceschi L. , Auriemma C. , Russo R. , De Falco L. , Vallefuoco F. , Esposito M.R. , Vandorpe D.H. , Shmukler B.E. , Narayan R. , Montanaro D. , D'Armiento M. , Vetro A. , Limongelli I. , Zuffardi O. , Glader B.E. , Schrier S.L. , more...
Blood121:3925-3935(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
5.

"Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells."
Peyronnet R. , Martins J.R. , Duprat F. , Demolombe S. , Arhatte M. , Jodar M. , Tauc M. , Duranton C. , Paulais M. , Teulon J. , Honore E. , Patel A.
EMBO Rep.14:1143-1148(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PKD2;FUNCTION
6.

"Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch."
Poole K. , Herget R. , Lapatsina L. , Ngo H.D. , Lewin G.R.
Nat. Commun.5:3520-3520(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STOML3
7.

"Piezo1, a mechanically activated ion channel, is required for vascular development in mice."
Ranade S.S. , Qiu Z. , Woo S.H. , Hur S.S. , Murthy S.E. , Cahalan S.M. , Xu J. , Mathur J. , Bandell M. , Coste B. , Li Y.S. , Chien S. , Patapoutian A.
Proc. Natl. Acad. Sci. U.S.A.111:10347-10352(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
8.

"Piezo1 integration of vascular architecture with physiological force."
Li J. , Hou B. , Tumova S. , Muraki K. , Bruns A. , Ludlow M.J. , Sedo A. , Hyman A.J. , McKeown L. , Young R.S. , Yuldasheva N.Y. , Majeed Y. , Wilson L.A. , Rode B. , Bailey M.A. , Kim H.R. , Fu Z. , Carter D.A. , more...
Nature515:279-282(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION

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