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Index > Protein center > PPP2R4(Gene name) > Human
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  • PPP2R4 (Gene name),
  • Serine/threonine-protein phosphatase 2A activator (Protein name ),  PTPA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    PPP2R4(PTPA);
    Protein name:
    Serine/threonine-protein phosphatase 2A activator;
    Alternative:
    Phosphotyrosyl phosphatase activator(PTPA);PP2A, subunit B', PR53 isoform;Serine/threonine-protein phosphatase 2A regulatory subunit B';Serine/threonine-protein phosphatase 2A regulatory subunit 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Associates with PP2A heterodimeric core enzyme PP2A(D), composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A). Interacts with PPP2CB.
    Function:
    PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) modulating its activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro). The phosphotyrosyl phosphatase activity is dependent of an ATPase activty of the PP2A(D):PPP2R4 complex. Is involved in apoptosis; the function appears to be independent from PP2A.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    358
    Sequence:
    50:
    MAEGERQPPP | DSSEEAPPAT | QNFIIPKKEI | HTVPDMGKWK | RSQAYADYIG | 
    100:
    FILTLNEGVK | GKKLTFEYRV | SEMWNEVHEE | KEQAAKQSVS | CDECIPLPRA | 
    150:
    GHCAPSEAIE | KLVALLNTLD | RWIDETPPVD | QPSRFGNKAY | RTWYAKLDEE | 
    200:
    AENLVATVVP | THLAAAVPEV | AVYLKESVGN | STRIDYGTGH | EAAFAAFLCC | 
    250:
    LCKIGVLRVD | DQIAIVFKVF | NRYLEVMRKL | QKTYRMEPAG | SQGVWGLDDF | 
    300:
    QFLPFIWGSS | QLIDHPYLEP | RHFVDEKAVN | ENHKDYMFLE | CILFITEMKT | 
    350:
    GPFAEHSNQL | WNISAVPSWS | KVNQGLIRMY | KAECLEKFPV | IQHFKFGSLL | 
    358:
    PIHPVTSG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein phosphatase 2A activator
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    E10699h
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    96T
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    ELISA Kit for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    E10699b
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    Packing:
    96T
    ELISA Kit for Human Serine/threonine-protein phosphatase 2A activator
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    ELISA Kit for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    E10699m
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    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein phosphatase 2A activator
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    U10699h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    U10699b
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    U10699m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Serine/threonine-protein phosphatase 2A activator
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    Please sign in first.
    Polyclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Polyclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    P10699Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Cat.:
    P10699Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Monoclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Monoclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Monoclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Monoclonal Antibody for Human Serine/threonine-protein phosphatase 2A activator
    Protein for Human Serine/threonine-protein phosphatase 2A activator
    Protein for Human Serine/threonine-protein phosphatase 2A activator
    Protein for Human Serine/threonine-protein phosphatase 2A activator
    Protein for Human Serine/threonine-protein phosphatase 2A activator

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    Linearity
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    References
    1. 1.
      "Molecular cloning, expression, and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A."
      Cayla X. , Van Hoof C. , Bosch M. , Waelkens E. , Peeters B. , Merlevede W. , Goris J.
      J. Biol. Chem.269:15668-15675(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
      tissue: Heart.
    2. 2.
      "Structure and chromosomal localization of the human gene of the phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A."
      Van Hoof C. , Aly M. , Garcia A. , Cayla X. , Cassiman J.-J. , Merlevede W. , Goris J.
      Genomics28:261-272(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
      tissue: Blood.
    3. 3.
      "Identification and characterization of alternative splice products encoded by the human phosphotyrosyl phosphatase activator gene."
      Janssens V. , van Hoof C. , Martens E. , de Baere I. , Merlevede W. , Goris J.
      Eur. J. Biochem.267:4406-4413(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2; 3 AND 4)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Testis.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT LEU-357
      tissue: Liver.
    7. 7.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    10. 10.
      "Overexpression of the cis/trans isomerase PTPA triggers caspase 3-dependent apoptosis."
      Azam S. , Drobetsky E. , Ramotar D.
      Apoptosis12:1243-1255(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;SUBCELLULAR LOCATION
    11. 11.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    12. 12.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "The crystal structure of a human PP2A phosphatase activator reveals a novel fold and highly conserved cleft implicated in protein-protein interactions."
      Magnusdottir A. , Stenmark P. , Flodin S. , Nyman T. , Hammarstroem M. , Ehn M. , Bakali H M.A. , Berglund H. , Nordlund P.
      J. Biol. Chem.281:22434-22438(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 22-358
    15. 15.
      "Crystal structure of the PP2A phosphatase activator: implications for its PP2A-specific PPIase activity."
      Leulliot N. , Vicentini G. , Jordens J. , Quevillon-Cheruel S. , Schiltz M. , Barford D. , van Tilbeurgh H. , Goris J.
      Mol. Cell23:413-424(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 20-357
    16. 16.
      "Structure and mechanism of the phosphotyrosyl phosphatase activator."
      Chao Y. , Xing Y. , Chen Y. , Xu Y. , Lin Z. , Li Z. , Jeffrey P.D. , Stock J.B. , Shi Y.
      Mol. Cell23:535-546(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS);FUNCTION IN MODULATION OF PP2A SUBSTRATE SPECIFICITY;ATP-BINDING;MUTAGENESIS OF ASP-185; ALA-239; GLY-240; VAL-244; GLU-305; GLY-325; MET-329 AND LYS-337;INTERACTION WITH THE PP2A(D) COMPLEX
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