Protein name:
Pyruvate carboxylase, mitochondrial ;
Alternative:
Pyruvic carboxylase (PCB) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
Subcellular Location:
Mitochondrion matrix
Protein Attributes:
50:
MLKFQTVRGG | LRLLGVRRSS | SAPVASPNVR | RLEYKPIKKV | MVANRGEIAI |
100:
RVFRACTELG | IRTVAVYSEQ | DTGQMHRQKA | DEAYLIGRGL | APVQAYLHIP |
150:
DIIKVAKENG | VDAVHPGYGF | LSERADFAQA | CQDAGVRFIG | PSPEVVRKMG |
200:
DKVEARAIAI | AAGVPVVPGT | DSPISSLHEA | HEFSNTFGFP | IIFKAAYGGG |
250:
GRGMRVVHSY | EELEENYTRA | YSEALAAFGN | GALFVEKFIE | KPRHIEVQIL |
300:
GDQYGNILHL | YERDCSIQRR | HQKVVEIAPA | THLDPQLRSR | LTSDSVKLAK |
350:
QVGYENAGTV | EFLVDKHGKH | YFIEVNSRLQ | VEHTVTEEIT | DVDLVHAQIH |
400:
VSEGRSLPDL | GLRQENIRIN | GCAIQCRVTT | EDPARSFQPD | TGRIEVFRSG |
450:
EGMGIRLDNA | SAFQGAVISP | HYDSLLVKVI | AHGKDHPTAA | TKMSRALAEF |
500:
RVRGVKTNIP | FLQNVLNNQQ | FLAGTVDTQF | IDENPELFQL | RPAQNRAQKL |
550:
LHYLGHVMVN | GPTTPIPVNV | SPSPVDPAVP | VVPIGPPPAG | FRDILLREGP |
600:
EGFARAVRNH | QGLLLMDTTF | RDAHQSLLAT | RVRTHDLKKI | APYVAHNFNK |
650:
LFSMENWGGA | TFDVAMRFLY | ECPWRRLQEL | RELIPNIPFQ | MLLRGANAVG |
700:
YTNYPDNVVF | KFCEVAKENG | MDVFRVFDSL | NYLPNMLLGM | EAAGSAGGVV |
750:
EAAISYTGDV | ADPSRTKYSL | EYYMGLAEEL | VRAGTHILCI | KDMAGLLKPA |
800:
ACTMLVSSLR | DRFPDLPLHI | HTHDTSGAGV | AAMLACAQAG | ADVVDVAVDS |
850:
MSGMTSQPSM | GALVACTKGT | PLDTEVPLER | VFDYSEYWEG | ARGLYAAFDC |
900:
TATMKSGNSD | VYENEIPGGQ | YTNLHFQAHS | MGLGSKFKEV | KKAYVEANQM |
950:
LGDLIKVTPS | SKIVGDLAQF | MVQNGLSRAE | AEAQAEELSF | PRSVVEFLQG |
1000:
YIGIPHGGFP | EPFRSKVLKD | LPRIEGRPGA | SLPPLNLKEL | EKDLIDRHGE |
1050:
EVTPEDVLSA | AMYPDVFAQF | KDFTATFGPL | DSLNTRLFLQ | GPKIAEEFEV |
1100:
ELERGKTLHI | KALAVSDLNR | AGQRQVFFEL | NGQLRSILVK | DTQAMKEMHF |
1150:
HPKALKDVKG | QIGAPMPGKV | IDIKVAAGDK | VAKGQPLCVL | SAMKMETVVT |
1178:
SPMEGTIRKV | HVTKDMTLEG | DDLILEIE
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Bovine
ELISA Kit for Mouse Pyruvate carboxylase, mitochondrial
ELISA Kit for Mouse Pyruvate carboxylase, mitochondrial
ELISA Kit for Mouse Pyruvate carboxylase, mitochondrial
ELISA Kit for Mouse Pyruvate carboxylase, mitochondrial
CLIA Kit for Mouse Pyruvate carboxylase, mitochondrial
CLIA Kit for Mouse Pyruvate carboxylase, mitochondrial
CLIA Kit for Mouse Pyruvate carboxylase, mitochondrial
CLIA Kit for Mouse Pyruvate carboxylase, mitochondrial
Polyclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Polyclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Polyclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Polyclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Monoclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Monoclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Monoclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Monoclonal Antibody for Mouse Pyruvate carboxylase, mitochondrial
Protein for Mouse Pyruvate carboxylase, mitochondrial
Protein for Mouse Pyruvate carboxylase, mitochondrial
Protein for Mouse Pyruvate carboxylase, mitochondrial
Protein for Mouse Pyruvate carboxylase, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Adipocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
4.
"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J.
,
Chen Y.
,
Tishkoff D.X.
,
Peng C.
,
Tan M.
,
Dai L.
,
Xie Z.
,
Zhang Y.
,
Zwaans B.M.
,
Skinner M.E.
,
Lombard D.B.
,
Zhao Y.
Mol. Cell50:919-930(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-79; LYS-442 AND LYS-988;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
5.
"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J.
,
Newman J.C.
,
Held J.M.
,
Cusack M.P.
,
Sorensen D.J.
,
Li B.
,
Schilling B.
,
Mooney S.D.
,
Kahn C.R.
,
Verdin E.
,
Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A.110:6601-6606(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-79; LYS-297; LYS-316; LYS-319; LYS-434; LYS-661; LYS-748; LYS-988; LYS-992; LYS-1061; LYS-1090 AND LYS-1124;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .