Rorc Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comRorc Polyclonal Antibody for Mouse(Mus musculus) | EIAab.com

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Rorc (Gene name),

Nuclear receptor ROR-gamma (Protein name ), RORG_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

Rorc(Nr1f3;Rorg;Thor);

Protein name:

Nuclear receptor ROR-gamma;

Alternative:

Nuclear receptor subfamily 1 group F member 3;Nuclear receptor RZR-gamma;Thymus orphan receptor(TOR);Retinoid-related orphan receptor-gamma;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

N/A

Function:

Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T helper cells into Th17 cells. Regulate the expression of several components of the circadian clock (By similarity). Isoform 2 negatively regulates expression of TNFSF6/FASL and IL2 production in T-cells. It also binds to the TEA promoter and may participate in the regulation of DNA accessibility in the TCR-Jalpha locus.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

516

Sequence:

50:

MDRAPQRHHR | TSRELLAAKK | THTSQIEVIP | CKICGDKSSG | IHYGVITCEG |

100:

CKGFFRRSQQ | CNVAYSCTRQ | QNCPIDRTSR | NRCQHCRLQK | CLALGMSRDA |

150:

VKFGRMSKKQ | RDSLHAEVQK | QLQQQQQQEQ | VAKTPPAGSR | GADTLTYTLG |

200:

LSDGQLPLGA | SPDLPEASAC | PPGLLRASGS | GPPYSNTLAK | TEVQGASCHL |

250:

EYSPERGKAE | GRDSIYSTDG | QLTLGRCGLR | FEETRHPELG | EPEQGPDSHC |

300:

IPSFCSAPEV | PYASLTDIEY | LVQNVCKSFR | ETCQLRLEDL | LRQRTNLFSR |

350:

EEVTSYQRKS | MWEMWERCAH | HLTEAIQYVV | EFAKRLSGFM | ELCQNDQIIL |

400:

LTAGAMEVVL | VRMCRAYNAN | NHTVFFEGKY | GGVELFRALG | CSELISSIFD |

450:

FSHFLSALCF | SEDEIALYTA | LVLINANRPG | LQEKRRVEHL | QYNLELAFHH |

500:

HLCKTHRQGL | LAKLPPKGKL | RSLCSQHVEK | LQIFQHLHPI | VVQAAFPPLY |

516:

KELFSTDVES | PEGLSK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

UniGene:

String:

Pfam:

KEGG:

Uniprot:

FOR

ELISA Kit for Mouse Nuclear receptor ROR-gamma

Cat.:

E10640m

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse Nuclear receptor ROR-gamma

Cat.:

E10640h

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96T

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CLIA Kit for Mouse Nuclear receptor ROR-gamma

Cat.:

U10640h

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96T

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CLIA Kit for Mouse Nuclear receptor ROR-gamma

Cat.:

U10640m

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Packing:

96T

Polyclonal Antibody for Mouse Nuclear receptor ROR-gamma

Polyclonal Antibody for Mouse Nuclear receptor ROR-gamma

Cat.:

P10640Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Nuclear receptor ROR-gamma

Monoclonal Antibody for Mouse Nuclear receptor ROR-gamma

Protein for Mouse Nuclear receptor ROR-gamma

Protein for Mouse Nuclear receptor ROR-gamma

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

s

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element."
Medvedev A. , Yan Z.H. , Hirose T. , Giguere V. , Jetten A.M.
Gene181:199-206(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.

"Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene."
Medvedev A. , Chistokhina A. , Hirose A. , Jetten A.M.
Genomics46:93-102(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
strain: 129.
3.

"TOR: a new orphan receptor expressed in the thymus that can modulate retinoid and thyroid hormone signals."
Ortiz M.A. , Piedrafita F.J. , Pfahl M. , Maki R.
Mol. Endocrinol.9:1679-1691(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: CD-1.
tissue: Thymus.
4.

"RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells."
He Y.-W. , Deftos M.L. , Ojala E.W. , Bevan M.J.
Immunity9:797-806(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION IN T CELLS;TISSUE SPECIFICITY
tissue: Thymus.
5.

"RORgammaT, a thymus-specific isoform of the orphan nuclear receptor RORg/TOR, is up-regulated by signaling through the pre-T cell receptor (TCR) and binds to the TEA promoter."
Villey I. , De Chasseval R. , De Villartay J.-P.
Eur. J. Immunol.29:4072-4080(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION IN PRE-TCR ACTIVATION (ISOFORM 2);TISSUE SPECIFICITY
tissue: Thymus.
6.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
strain: NOD.
tissue: Thymus.
7.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
9.

"An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells."
Eberl G. , Marmon S. , Sunshine M.J. , Rennert P.D. , Choi Y. , Littman D.R.
Nat. Immunol.5:64-73(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THYMOPOIESIS (ISOFORM 2);DISRUPTION PHENOTYPE (ISOFORM 2);DEVELOPMENTAL STAGE (ISOFORM 2);TISSUE SPECIFICITY (ISOFORM 2)
10.

"RORgammat recruits steroid receptor coactivators to ensure thymocyte survival."
Xie H. , Sadim M.S. , Sun Z.
J. Immunol.175:3800-3809(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN THYMOCYTE SURVIVAL (ISOFORM 2);INTERACTION WITH NCOA1 AND NCOA2;DISRUPTION PHENOTYPE;DNA-BINDING;MUTAGENESIS OF 56-ARG-ARG-57 AND TYR-500;DOMAIN
11.

"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells."
Ivanov I.I. , McKenzie B.S. , Zhou L. , Tadokoro C.E. , Lepelley A. , Lafaille J.J. , Cua D.J. , Littman D.R.
Cell126:1121-1133(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2);DISRUPTION PHENOTYPE (ISOFORM 2);INDUCTION BY IL6 AND TGFB1 (ISOFORM 2);TISSUE SPECIFICITY (ISOFORM 2)
12.

"Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism."
Liu C. , Li S. , Liu T. , Borjigin J. , Lin J.D.
Nature447:477-481(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPARGC1A
13.

"Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism."
Kang H.S. , Angers M. , Beak J.Y. , Wu X. , Gimble J.M. , Wada T. , Xie W. , Collins J.B. , Grissom S.F. , Jetten A.M.
Physiol. Genomics31:281-294(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN METABOLISM REGULATION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE;TISSUE SPECIFICITY
14.

"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma."
Yang X.O. , Pappu B.P. , Nurieva R. , Akimzhanov A. , Kang H.S. , Chung Y. , Ma L. , Shah B. , Panopoulos A.D. , Schluns K.S. , Watowich S.S. , Tian Q. , Jetten A.M. , Dong C.
Immunity28:29-39(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN T(H)17 CELLS DIFFERENTIATION (ISOFORM 2);INDUCTION BY IL6 AND TGB1 (ISOFORM 2);TISSUE SPECIFICITY (ISOFORM 2)
15.

"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism."
Jetten A.M.
Nucl. Recept. Signal.7:3-35(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
16.

"Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands."
Wang Y. , Kumar N. , Solt L.A. , Richardson T.I. , Helvering L.M. , Crumbley C. , Garcia-Ordonez R.D. , Stayrook K.R. , Zhang X. , Novick S. , Chalmers M.J. , Griffin P.R. , Burris T.P.
J. Biol. Chem.285:5013-5025(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN GLUCOSE METABOLISM REGULATION;IDENTIFICATION OF LIGANDS
17.

"Adipogenesis and insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma."
Meissburger B. , Ukropec J. , Roeder E. , Beaton N. , Geiger M. , Teupser D. , Civan B. , Langhans W. , Nawroth P.P. , Gasperikova D. , Rudofsky G. , Wolfrum C.
EMBO Mol. Med.3:637-651(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ADIPOGENESIS;DISRUPTION PHENOTYPE;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;MUTAGENESIS OF CYS-31 AND CYS-48
18.

"Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand."
Solt L.A. , Kumar N. , Nuhant P. , Wang Y. , Lauer J.L. , Liu J. , Istrate M.A. , Kamenecka T.M. , Roush W.R. , Vidovic D. , Schuerer S.C. , Xu J. , Wagoner G. , Drew P.D. , Griffin P.R. , Burris T.P.
Nature472:491-494(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NCOR1 AND NCOA2;IDENTIFICATION OF LIGANDS
19.

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Lamia K.A. , Papp S.J. , Yu R.T. , Barish G.D. , Uhlenhaut N.H. , Jonker J.W. , Downes M. , Evans R.M.
Nature480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1
20.

"RORgamma directly regulates the circadian expression of clock genes and downstream targets in vivo."
Takeda Y. , Jothi R. , Birault V. , Jetten A.M.
Nucleic Acids Res.40:8519-8535(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN RHYTHMS;TISSUE SPECIFICITY;INDUCTION;SUBCELLULAR LOCATION;DNA-BINDING;DISRUPTION PHENOTYPE;MUTAGENESIS OF GLU-502
21.

"Action of RORs and their ligands in (patho)physiology."
Solt L.A. , Burris T.P.
Trends Endocrinol. Metab.23:619-627(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION AND LIGANDS
22.

"Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation."
Takeda Y. , Jetten A.M.
Nucleic Acids Res.41:6992-7008(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PROX1

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