Gene name:
SLC12A5 (KCC2;KIAA1176) ;
Protein name:
Solute carrier family 12 member 5 ;
Alternative:
K-Cl cotransporter 2 (hKCC2) ;Electroneutral potassium-chloride cotransporter 2 ;Neuronal K-Cl cotransporter ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1.
Function:
Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
Subcellular Location:
Membrane
Multi-pass membrane protein
Protein Attributes:
50:
MSRRFTVTSL | PPAGPARSPD | PESRRHSVAD | PRHLPGEDVK | GDGNPKESSP |
100:
FINSTDTEKG | KEYDGKNMAL | FEEEMDTSPM | VSSLLSGLAN | YTNLPQGSRE |
150:
HEEAENNEGG | KKKPVQAPRM | GTFMGVYLPC | LQNIFGVILF | LRLTWVVGIA |
200:
GIMESFCMVF | ICCSCTMLTA | ISMSAIATNG | VVPAGGSYYM | ISRSLGPEFG |
250:
GAVGLCFYLG | TTFAGAMYIL | GTIEILLAYL | FPAMAIFKAE | DASGEAAAML |
300:
NNMRVYGTCV | LTCMATVVFV | GVKYVNKFAL | VFLGCVILSI | LAIYAGVIKS |
350:
AFDPPNFPIC | LLGNRTLSRH | GFDVCAKLAW | EGNETVTTRL | WGLFCSSRFL |
400:
NATCDEYFTR | NNVTEIQGIP | GAASGLIKEN | LWSSYLTKGV | IVERSGMTSV |
450:
GLADGTPIDM | DHPYVFSDMT | SYFTLLVGIY | FPSVTGIMAG | SNRSGDLRDA |
500:
QKSIPTGTIL | AIATTSAVYI | SSVVLFGACI | EGVVLRDKFG | EAVNGNLVVG |
550:
TLAWPSPWVI | VIGSFFSTCG | AGLQSLTGAP | RLLQAISRDG | IVPFLQVFGH |
600:
GKANGEPTWA | LLLTACICEI | GILIASLDEV | APILSMFFLM | CYMFVNLACA |
650:
VQTLLRTPNW | RPRFRYYHWT | LSFLGMSLCL | ALMFICSWYY | ALVAMLIAGL |
700:
IYKYIEYRGA | EKEWGDGIRG | LSLSAARYAL | LRLEEGPPHT | KNWRPQLLVL |
750:
VRVDQDQNVV | HPQLLSLTSQ | LKAGKGLTIV | GSVLEGTFLE | NHPQAQRAEE |
800:
SIRRLMEAEK | VKGFCQVVIS | SNLRDGVSHL | IQSGGLGGLQ | HNTVLVGWPR |
850:
NWRQKEDHQT | WRNFIELVRE | TTAGHLALLV | TKNVSMFPGN | PERFSEGSID |
900:
VWWIVHDGGM | LMLLPFLLRH | HKVWRKCKMR | IFTVAQMDDN | SIQMKKDLTT |
950:
FLYHLRITAE | VEVVEMHESD | ISAYTYEKTL | VMEQRSQILK | QMHLTKNERE |
1000:
REIQSITDES | RGSIRRKNPA | NTRLRLNVPE | ETAGDSEEKP | EEEVQLIHDQ |
1050:
SAPSCPSSSP | SPGEEPEGEG | ETDPEKVHLT | WTKDKSVAEK | NKGPSPVSSE |
1100:
GIKDFFSMKP | EWENLNQSNV | RRMHTAVRLN | EVIVKKSRDA | KLVLLNMPGP |
1139:
PRNRNGDENY | MEFLEVLTEH | LDRVMLVRGG | GREVITIYS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Rat
ELISA Kit for Human Solute carrier family 12 member 5
ELISA Kit for Human Solute carrier family 12 member 5
ELISA Kit for Human Solute carrier family 12 member 5
CLIA Kit for Human Solute carrier family 12 member 5
CLIA Kit for Human Solute carrier family 12 member 5
CLIA Kit for Human Solute carrier family 12 member 5
Polyclonal Antibody for Human Solute carrier family 12 member 5
Polyclonal Antibody for Human Solute carrier family 12 member 5
Polyclonal Antibody for Human Solute carrier family 12 member 5
Monoclonal Antibody for Human Solute carrier family 12 member 5
Monoclonal Antibody for Human Solute carrier family 12 member 5
Monoclonal Antibody for Human Solute carrier family 12 member 5
Protein for Human Solute carrier family 12 member 5
Protein for Human Solute carrier family 12 member 5
Protein for Human Solute carrier family 12 member 5
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter."
Song L.
,
Mercado A.
,
Vazquez N.
,
Xie Q.
,
Desai R.
,
George A.L. Jr.
,
Gamba G.
,
Mount D.B.
Brain Res. Mol. Brain Res.103:91-105(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Brain .
2.
"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P.
,
Matthews L.H.
,
Ashurst J.L.
,
Burton J.
,
Gilbert J.G.R.
,
Jones M.
,
Stavrides G.
,
Almeida J.P.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Barlow K.F.
,
Bates K.N.
,
Beard L.M.
,
Beare D.M.
,
Beasley O.P.
,
Bird C.P.
,
Blakey S.E.
,
Bridgeman A.M.
,
Brown A.J.
,
Buck D.
,
Burrill W.D.
,
Butler A.P.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clamp M.
,
Clark G.
,
Clark L.N.
,
Clark S.Y.
,
Clee C.M.
,
Clegg S.
,
Cobley V.E.
,
Collier R.E.
,
Connor R.E.
,
Corby N.R.
,
Coulson A.
,
Coville G.J.
,
Deadman R.
,
Dhami P.D.
,
Dunn M.
,
Ellington A.G.
,
Frankland J.A.
,
Fraser A.
,
French L.
,
Garner P.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths M.N.D.
,
Gwilliam R.
,
Hall R.E.
,
Hammond S.
,
Harley J.L.
,
Heath P.D.
,
Ho S.
,
Holden J.L.
,
Howden P.J.
,
Huckle E.
,
Hunt A.R.
,
Hunt S.E.
,
Jekosch K.
,
Johnson C.M.
,
Johnson D.
,
Kay M.P.
,
Kimberley A.M.
,
King A.
,
Knights A.
,
Laird G.K.
,
Lawlor S.
,
Lehvaeslaiho M.H.
,
Leversha M.A.
,
Lloyd C.
,
Lloyd D.M.
,
Lovell J.D.
,
Marsh V.L.
,
Martin S.L.
,
McConnachie L.J.
,
McLay K.
,
McMurray A.A.
,
Milne S.A.
,
Mistry D.
,
Moore M.J.F.
,
Mullikin J.C.
,
Nickerson T.
,
Oliver K.
,
Parker A.
,
Patel R.
,
Pearce T.A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Prathalingam S.R.
,
Plumb R.W.
,
Ramsay H.
,
Rice C.M.
,
Ross M.T.
,
Scott C.E.
,
Sehra H.K.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.L.
,
Soderlund C.
,
Steward C.A.
,
Sulston J.E.
,
Swann R.M.
,
Sycamore N.
,
Taylor R.
,
Tee L.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.C.
,
Vaudin M.
,
Wall M.
,
Wallis J.M.
,
Whitehead S.L.
,
Whittaker P.
,
Willey D.L.
,
Williams L.
,
Williams S.A.
,
Wilming L.
,
Wray P.W.
,
Hubbard T.
,
Durbin R.M.
,
Bentley D.R.
,
Beck S.
,
Rogers J.
more...
Nature414:865-871(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
4.
"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes."
Kimura K.
,
Wakamatsu A.
,
Suzuki Y.
,
Ota T.
,
Nishikawa T.
,
Yamashita R.
,
Yamamoto J.
,
Sekine M.
,
Tsuritani K.
,
Wakaguri H.
,
Ishii S.
,
Sugiyama T.
,
Saito K.
,
Isono Y.
,
Irie R.
,
Kushida N.
,
Yoneyama T.
,
Otsuka R.
,
Kanda K.
,
Yokoi T.
,
Kondo H.
,
Wagatsuma M.
,
Murakawa K.
,
Ishida S.
,
Ishibashi T.
,
Takahashi-Fujii A.
,
Tanase T.
,
Nagai K.
,
Kikuchi H.
,
Nakai K.
,
Isogai T.
,
Sugano S.
more...
Genome Res.16:55-65(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-175 (ISOFORM 1)
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-1109 (ISOFORM 2);VARIANT LEU-1100
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION
7.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] ASP-847