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Index > Protein center > Scn9a(Gene name) > Rat
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  • Scn9a (Gene name),
  • Sodium channel protein type 9 subunit alpha (Protein name ),  SCN9A_RAT from NCBI database.
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  • Gene name:
    Scn9a;
    Protein name:
    Sodium channel protein type 9 subunit alpha;
    Alternative:
    Sodium channel protein type IX subunit alpha;Peripheral sodium channel 1(PN1);Voltage-gated sodium channel subunit alpha Nav1.7;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L.
    Function:
    Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
    Subcellular Location:
    Membrane Multi-pass membrane protein In neurite terminals.
    Protein Attributes:
    Sequence length:
    1984
    Sequence:
    50:
    MAMLPPPGPQ | SFVHFTKQSL | ALIEQRISEE | KAKEHKDEKK | DDEEEGPKPS | 
    100:
    SDLEAGKQLP | FIYGDIPPGM | VSEPLEDLDP | YYADKKTFIV | LNKGKAIFRF | 
    150:
    NATPALYMLS | PFSPLRRISI | KILVHSLFSM | LIMCTILTNC | IFMTLSNPPE | 
    200:
    WTKNVEYTFT | GIYTFESLIK | ILARGFCVGE | FTFLRDPWNW | LDFVVIVFAY | 
    250:
    LTEFVNLGNV | SALRTFRVLR | ALKTISVIPG | LKTIVGALIQ | SVKKLSDVMI | 
    300:
    LTVFCLSVFA | LIGLQLFMGN | LKHKCFRKEL | EENETLESIM | NTAESEEELK | 
    350:
    KYFYYLEGSK | DALLCGFSTD | SGQCPEGYIC | VKAGRNPDYG | YTSFDTFSWA | 
    400:
    FLALFRLMTQ | DYWENLYQQT | LRAAGKTYMI | FFVVVIFLGS | FYLINLILAV | 
    450:
    VAMAYEEQNQ | ANIEEAKQKE | LEFQQMLDRL | KKEQEEAEAI | AAAAAEFTSI | 
    500:
    GRSRIMGLSE | SSSETSRLSS | KSAKERRNRR | KKKKQKMSSG | EEKGDDEKLS | 
    550:
    KSGSEESIRK | KSFHLGVEGH | HRTREKRLST | PNQSPLSIRG | SLFSARRSSR | 
    600:
    TSLFSFKGRG | RDLGSETEFA | DDEHSIFGDN | ESRRGSLFVP | HRPRERRSSN | 
    650:
    ISQASRSPPV | LPVNGKMHSA | VDCNGVVSLV | DGPSALMLPN | GQLLPEVIID | 
    700:
    KATSDDSGTT | NQMRKKRLSS | SYFLSEDMLN | DPHLRQRAMS | RASILTNTVE | 
    750:
    ELEESRQKCP | PWWYRFAHTF | LIWNCSPYWI | KFKKLIYFIV | MDPFVDLAIT | 
    800:
    ICIVLNTLFM | AMEHHPMTEE | FKNVLAVGNL | IFTGIFAAEM | VLKLIAMDPY | 
    850:
    EYFQVGWNIF | DSLIVTLSLI | ELFLADVEGL | SVLRSFRLLR | VFKLAKSWPT | 
    900:
    LNMLIKIIGN | SVGALGNLTL | VLAIIVFIFA | VVGMQLFGKS | YKECVCKINV | 
    950:
    DCKLPRWHMN | DFFHSFLIVF | RVLCGEWIET | MWDCMEVAGQ | TMCLIVYMMV | 
    1000:
    MVIGNLVVLN | LFLALLLSSF | SSDNLTAIEE | DTDANNLQIA | VARIKRGINY | 
    1050:
    VKQTLREFIL | KSFSKKPKGS | KDTKRTADPN | NKKENYISNR | TLAEMSKDHN | 
    1100:
    FLKEKDRISG | YGSSLDKSFM | DENDYQSFIH | NPSLTVTVPI | APGESDLEIM | 
    1150:
    NTEELSSDSD | SDYSKEKRNR | SSSSECSTVD | NPLPGEEEAE | AEPVNADEPE | 
    1200:
    ACFTDGCVRR | FPCCQVNVDS | GKGKVWWTIR | KTCYRIVEHS | WFESFIVLMI | 
    1250:
    LLSSGALAFE | DIYIEKKKTI | KIILEYADKI | FTYIFILEML | LKWVAYGYKT | 
    1300:
    YFTNAWCWLD | FLIVDVSLVT | LVANTLGYSD | LGPIKSLRTL | RALRPLRALS | 
    1350:
    RFEGMRVVVN | ALIGAIPSIM | NVLLVCLIFW | LIFSIMGVNL | FAGKFYECVN | 
    1400:
    TTDGSRFPTS | QVANRSECFA | LMNVSGNVRW | KNLKVNFDNV | GLGYLSLLQV | 
    1450:
    ATFKGWMDIM | YAAVDSVNVN | EQPKYEYSLY | MYIYFVIFII | FGSFFTLNLF | 
    1500:
    IGVIIDNFNQ | QKKKLGGQDI | FMTEEQKKYY | NAMKKLGSKK | PQKPIPRPGN | 
    1550:
    KFQGCIFDLV | TNQAFDITIM | VLICLNMVTM | MVEKEGQTEY | MDYVLHWINM | 
    1600:
    VFIILFTGEC | VLKLISLRHY | YFTVGWNIFD | FVVVILSIVG | MFLAEMIEKY | 
    1650:
    FVSPTLFRVI | RLARIGRILR | LIKGAKGIRT | LLFALMMSLP | ALFNIGLLLF | 
    1700:
    LVMFIYAIFG | MSNFAYVKKE | AGINDMFNFE | TFGNSMICLF | QITTSAGWDG | 
    1750:
    LLAPILNSAP | PDCDPKKVHP | GSSVEGDCGN | PSVGIFYFVS | YIIISFLVVV | 
    1800:
    NMYIAVILEN | FSVATEESTE | PLSEDDFEMF | YEVWEKFDPD | ATQFIEFCKL | 
    1850:
    SDFAAALDPP | LLIAKPNKVQ | LIAMDLPMVS | GDRIHCLDIL | FAFTKRVLGE | 
    1900:
    GGEMDSLRSQ | MEERFMSANP | SKVSYEPITT | TLKRKQEEVS | ATIIQRAYRR | 
    1950:
    YRLRQHVKNI | SSIYIKDGDR | DDDLPNKEDT | VFDNVNENSS | PEKTDVTAST | 
    1984:
    ISPPSYDSVT | KPDQEKYETD | KTEKEDKEKD | ESRK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    E15345h
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    96T
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    ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
    MSDS:
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    ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    E15345m
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    Packing:
    96T
    ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    E15345r
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    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    U15345r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    U15345m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    U15345h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    P15345Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    P15345Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Cat.:
    P15345Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
    Protein for Rat Sodium channel protein type 9 subunit alpha
    Protein for Rat Sodium channel protein type 9 subunit alpha
    Protein for Rat Sodium channel protein type 9 subunit alpha
    Protein for Rat Sodium channel protein type 9 subunit alpha

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    References
    1. 1.
      "Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons."
      Toledo-Aral J.J. , Moss B.L. , He Z.J. , Koszowski A.G. , Whisenand T. , Levinson S.R. , Wolf J.J. , Silos-Santiago I. , Halegoua S. , Mandel G.
      Proc. Natl. Acad. Sci. U.S.A.94:1527-1532(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION
    2. 2.
      "A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia."
      Sangameswaran L. , Fish L.M. , Koch B.D. , Rabert D.K. , Delgado S.G. , Ilnicka M. , Jakeman L.B. , Novakovic S. , Wong K. , Sze P. , Tzoumaka E. , Stewart G.R. , Herman R.C. , Chan H. , Eglen R.M. , Hunter J.C.
      J. Biol. Chem.272:14805-14809(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Spinal ganglion.
    3. 3.
      Lubec G. , Kang S.U. , Lubec S.
      Submitted (2007-09) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 527-547;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
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