Set Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comSet Polyclonal Antibody for Mouse(Mus musculus)

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Set (Gene name),

Protein SET (Protein name ), SET_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Set;

Protein name:

Protein SET;

Alternative:

Template-activating factor I(TAF-I);Phosphatase 2A inhibitor I2PP2A(I-2PP2A);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Isoform 1 and isoform 2 interact directly with each other and with ANP32A within the tripartite INHAT (inhibitor of acetyltransferases) complex. Isoform 1 and isoform 2 interact also with histones. Isoform 2 is a component of the SET complex, which also contains ANP32A, APEX1, HMGB2 and NME1, but not NME2. Within this complex, directly interacts with NME1 and with HMGB2. Interacts with SETBP1 (By similarity). Interacts with SGOL1 (By similarity). Interacts with APBB1.

Function:

Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher.

Subcellular Location:

Cytoplasm cytosol Endoplasmic reticulum Nucleus nucleoplasm In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. Following CTL attack, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte-activated killer cells after the addition of calcium. The SET complex is associated with the endoplasmic reticulum.

Protein Attributes:

Sequence length:

289

Sequence:

50:

100:

150:

200:

250:

289:

DEEEEGLEDI | DEEGDEDEGE | EDDDEDEGEE | GEEDEGEDD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.335942

Pfam:

PF00956

KEGG:

mmu:56086

SMR:

Q9EQU5

String:

Q9EQU5

Uniprot:

Q9EQU5

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ELISA Kit for Mouse Protein SET

Cat.:

E14249h

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96T

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ELISA Kit for Mouse Protein SET

Cat.:

E14249m

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96T

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ELISA Kit for Mouse Protein SET

Cat.:

E14249r

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96T

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CLIA Kit for Mouse Protein SET

Cat.:

U14249h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein SET

Cat.:

U14249r

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein SET

Cat.:

U14249m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Protein SET

Cat.:

P14249Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein SET

Cat.:

P14249Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Protein SET

Cat.:

P14249Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Protein SET

Protein for Mouse Protein SET

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Up-regulation of I-2PP2A/SET gene expression in rat primary hepatomas and regenerating livers."
Fukukawa C. , Shima H. , Tamura N. , Ogawa K. , Kikuchi K.
Cancer Lett.161:89-95(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: C57BL/6 X DBA/2.
tissue: Blastocyst.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
strain: C57BL/6J.
tissue: Embryo.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: Czech II.
tissue: Mammary tumor.
5.

"Identification and characterization of SEB, a novel protein that binds to the acute undifferentiated leukemia-associated protein SET."
Minakuchi M. , Kakazu N. , Gorrin-Rivas M.J. , Abe T. , Copeland T.D. , Ueda K. , Adachi Y.
Eur. J. Biochem.268:1340-1351(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-222 (ISOFORM 2)
tissue: Embryo.
6.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-145;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
7.

"Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."
Rogowski K. , Juge F. , van Dijk J. , Wloga D. , Strub J.-M. , Levilliers N. , Thomas D. , Bre M.-H. , Van Dorsselaer A. , Gaertig J. , Janke C.
Cell137:1076-1087(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCYLATION
8.

"NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein."
Tooley C.E. , Petkowski J.J. , Muratore-Schroeder T.L. , Balsbaugh J.L. , Shabanowitz J. , Sabat M. , Minor W. , Hunt D.F. , Macara I.G.
Nature466:1125-1128(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE OF INITIATOR METHIONINE;METHYLATION AT ALA-2;MUTAGENESIS OF LYS-4
9.

"Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation."
Fanis P. , Gillemans N. , Aghajanirefah A. , Pourfarzad F. , Demmers J. , Esteghamat F. , Vadlamudi R.K. , Grosveld F. , Philipsen S. , van Dijk T.B.
Mol. Cell. Proteomics11:1263-1273(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CHTOP
10.

"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J. , Chen Y. , Tishkoff D.X. , Peng C. , Tan M. , Dai L. , Xie Z. , Zhang Y. , Zwaans B.M. , Skinner M.E. , Lombard D.B. , Zhao Y.
Mol. Cell50:919-930(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-23 AND LYS-67;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic fibroblast.

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