Slamf1 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comSlamf1 Polyclonal Antibody for Mouse(Mus musculus)

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Slamf1 (Gene name),

Signaling lymphocytic activation molecule (Protein name ), SLAF1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Slamf1(Slam);

Protein name:

Signaling lymphocytic activation molecule;

Alternative:

CD:

CD150;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with INPP5D/SHIP1 (By similarity). Interacts (via cytoplasmic domain) with SH2D1A. Interacts (upon tyrosine phosphorylation with) PTPN11, but not with SHP-1.

Function:

High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Present on the surface of B-cells and T-cells.

Protein Attributes:

Sequence length:

343

Sequence:

50:

100:

150:

200:

250:

300:

343:

LHDALTDQDP | CTTIYVAATE | PAPESVQEPN | PTTVYASVTL | PES

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9QUM4

KEGG:

mmu:27218

Pfam:

PF06214

UniGene:

Mm.103648

SMR:

Q9QUM4

Uniprot:

Q9QUM4

FOR

ELISA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

E9273d

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

E9273h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

E9273m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

U9273d

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

U9273h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Signaling lymphocytic activation molecule

Cat.:

U9273m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Signaling lymphocytic activation molecule

Cat.:

P9273Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Signaling lymphocytic activation molecule

Cat.:

P9273Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Signaling lymphocytic activation molecule

Monoclonal Antibody for Mouse Signaling lymphocytic activation molecule

Protein for Mouse Signaling lymphocytic activation molecule

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular and functional characterization of mouse signaling lymphocytic activation molecule (SLAM): differential expression and responsiveness in Th1 and Th2 cells."
Castro A.G. , Hauser T.M. , Cocks B.G. , Abrams J. , Zurawski S. , Churakova T. , Zonin F. , Robinson D. , Tangye S.G. , Aversa G. , Nichols K.E. , de Vries J.E. , Lanier L.L. , O'Garra A.
J. Immunol.163:5860-5870(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT)
strain: BALB/c.
2.

"The cell surface receptor SLAM controls T cell and macrophage functions."
Wang N. , Satoskar A. , Faubion W. , Howie D. , Okamoto S. , Feske S. , Gullo C. , Clarke K. , Sosa M.R. , Sharpe A.H. , Terhorst C.
J. Exp. Med.199:1255-1264(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM LONG)
3.

"Genomic organization of murine Slam."
Wu C. , Wang N. , Sayos J. , Terhorst C.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
4.

"Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells."
Morra M. , Lu J. , Poy F. , Martin M. , Sayos J. , Calpe S. , Gullo C. , Howie D. , Rietdijk S. , Thompson A. , Coyle A.J. , Denny C. , Yaffe M.B. , Engel P. , Eck M.J. , Terhorst C.
EMBO J.20:5840-5852(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH2D1B

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