TAB2 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comTAB2 Polyclonal Antibody for Human(Homo sapiens)

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TAB2 (Gene name),

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Protein name ), TAB2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

TAB2(KIAA0733;MAP3K7IP2);

Protein name:

TGF-beta-activated kinase 1 and MAP3K7-binding protein 2;

Alternative:

TAK1-binding protein 2(TAB-2);Mitogen-activated protein kinase kinase kinase 7-interacting protein 2;TGF-beta-activated kinase 1-binding protein 2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with MAP3K7 and TRAF6. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Binds 'Lys-63'-linked polyubiquitin chains. Interacts with NCOR1 and HDAC3 to form a ternary complex. Interacts (via C-terminal) with NUMBL (via PTB domain). Interacts (via the C-terminus) with WDR34 (via WD domains). Interacts with RBCK1.

Function:

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.

Subcellular Location:

Membrane Peripheral membrane protein Cytoplasm cytosol Following IL1 stimulation, translocation occurs from the membrane to cytosol.

Protein Attributes:

Sequence length:

693

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

693:

IIKTPKTQDT | EDDEGAQWNC | TACTFLNHPA | LIRCEQCEMP | RHF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

605101

String:

Q9NYJ8

Pfam:

PF02845

UniGene:

Hs.269775

KEGG:

hsa:23118

SMR:

Q9NYJ8

Uniprot:

Q9NYJ8

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ELISA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882h

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96T

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ELISA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882r

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96T

ELISA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

E2882m

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96T

CLIA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882r

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Packing:

96T

CLIA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882m

Price:

Please sign in first.

MSDS:

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Packing:

96T

CLIA Kit for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

U2882h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Cat.:

P2882Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Protein for Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.9%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.7%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of ACE into serum and plasma .

Sample Type	Average(%)	Recovery Range(%)
Serum	99	91-103
Plasma	98	93-106

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	92-105%	90-101%	95-105%	92-109%
EDTA plasma(n=5)	89-95%	93105%	89-94%	90-106%
heparin plasma(n=5)	93-104%	94-110%	101-111%	91-110%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway."
Takaesu G. , Kishida S. , Hiyama A. , Yamaguchi K. , Shibuya H. , Irie K. , Ninomiya-Tsuji J. , Matsumoto K.
Mol. Cell5:649-658(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION;INTERACTION WITH TAK1 AND TRAF6
tissue: Kidney.
2.

"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
5.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
6.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
7.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2005-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Eye.
11.

"TAK1 is a ubiquitin-dependent kinase of MKK and IKK."
Wang C. , Deng L. , Hong M. , Akkaraju G.R. , Inoue J. , Chen Z.J.
Nature412:346-351(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;IDENTIFICATION IN THE TRIKA2 COMPLEX
12.

"Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling."
Ishitani T. , Takaesu G. , Ninomiya-Tsuji J. , Shibuya H. , Gaynor R.B. , Matsumoto K.
EMBO J.22:6277-6288(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION
tissue: Kidney.
13.

"RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation."
Tian Y. , Zhang Y. , Zhong B. , Wang Y.Y. , Diao F.C. , Wang R.P. , Zhang M. , Chen D.Y. , Zhai Z.H. , Shu H.B.
J. Biol. Chem.282:16776-16782(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;INTERACTION WITH RBCK1
14.

"NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation."
Ma Q. , Zhou L. , Shi H. , Huo K.
Cell. Signal.20:1044-1051(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NUMBL
15.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-372;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
16.

"WDR34 is a novel TAK1-associated suppressor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway."
Gao D. , Wang R. , Li B. , Yang Y. , Zhai Z. , Chen D.Y.
Cell. Mol. Life Sci.66:2573-2584(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WDR34
17.

"Direct activation of protein kinases by unanchored polyubiquitin chains."
Xia Z.-P. , Sun L. , Chen X. , Pineda G. , Jiang X. , Adhikari A. , Zeng W. , Chen Z.J.
Nature461:114-119(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH POLYUBIQUITIN
18.

"Haploinsufficiency of TAB2 causes congenital heart defects in humans."
Thienpont B. , Zhang L. , Postma A.V. , Breckpot J. , Tranchevent L.C. , Van Loo P. , Mollgard K. , Tommerup N. , Bache I. , Tumer Z. , van Engelen K. , Menten B. , Mortier G. , Waggoner D. , Gewillig M. , Moreau Y. , Devriendt K. , Larsen L.A.
Am. J. Hum. Genet.86:839-849(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HEART DEVELOPMENT;TISSUE SPECIFICITY;VARIANTS CHTD2 SER-208 AND LYS-230;CHROMOSOMAL TRANSLOCATION
19.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-450 AND SER-524;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"TRIM5 is an innate immune sensor for the retrovirus capsid lattice."
Pertel T. , Hausmann S. , Morger D. , Zueger S. , Guerra J. , Lascano J. , Reinhard C. , Santoni F.A. , Uchil P.D. , Chatel L. , Bisiaux A. , Albert M.L. , Strambio-De-Castillia C. , Mothes W. , Pizzato M. , Gruetter M.G. , Luban J.
Nature472:361-365(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM5
22.

"Solution structure of the N-terminal CUE domain in the human mitogen-activated protein kinase kinase kinase 7-interacting protein 2 (MAP3K7IP2)."
RIKEN structural genomics initiative (RSGI)
Submitted (2007-02) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 5-70
23.

"Two-sided ubiquitin binding explains specificity of the TAB2 NZF domain."
Kulathu Y. , Akutsu M. , Bremm A. , Hofmann K. , Komander D.
Nat. Struct. Mol. Biol.16:1328-1330(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 662-693 IN COMPLEX WITH POLYUBIQUITIN CHAINS;MUTAGENESIS OF PHE-675; HIS-678; LEU-681 AND GLU-685;SUBUNIT

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