Vangl2 Polyclonal Antibody for Mouse(Mus musculus) | EIAab.comVangl2 Polyclonal Antibody for Mouse(Mus musculus)

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Index > Protein center > Vangl2(Gene name) > Mouse

Vangl2 (Gene name),

Vang-like protein 2 (Protein name ), VANG2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Vangl2(Lpp1;Ltap);

Protein name:

Vang-like protein 2;

Alternative:

Loop-tail-associated protein;Loop-tail protein 1;Van Gogh-like protein 2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Variants Glu-255 and Asn-464 impair interaction with the DVL proteins. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3.

Function:

Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

521

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

521:

EEFVDPKSHK | FVMRLQSETS | V

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.36148

String:

Q91ZD4

KEGG:

mmu:93840

Pfam:

PF06638

STRING:

10090.ENSMUSP00000106895

Uniprot:

Q91ZD4

FOR

ELISA Kit for Mouse Vang-like protein 2

Cat.:

E15196h

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96T

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ELISA Kit for Mouse Vang-like protein 2

Cat.:

E15196r

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96T

ELISA Kit for Mouse Vang-like protein 2

Cat.:

E15196m

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96T

CLIA Kit for Mouse Vang-like protein 2

Cat.:

U15196m

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MSDS:

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96T

CLIA Kit for Mouse Vang-like protein 2

Cat.:

U15196h

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MSDS:

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96T

CLIA Kit for Mouse Vang-like protein 2

Cat.:

U15196r

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96T

Polyclonal Antibody for Mouse Vang-like protein 2

Cat.:

P15196Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Vang-like protein 2

Cat.:

P15196Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Vang-like protein 2

Cat.:

P15196Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse Vang-like protein 2

Protein for Mouse Vang-like protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specification."
Murdoch J.N. , Doudney K. , Paternotte C. , Copp A.J. , Stanier P.
Hum. Mol. Genet.10:2593-2601(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANT LP ASN-464
strain: C57BL/6.
2.

"Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant loop-tail."
Kibar Z. , Vogan K.J. , Groulx N. , Justice M.J. , Underhill D.A. , Gros P.
Nat. Genet.28:251-255(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY;VARIANTS LP GLU-255 AND ASN-464
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Limb.
4.

"Cardiovascular defects associated with abnormalities in midline development in the loop-tail mouse mutant."
Henderson D.J. , Conway S.J. , Greene N.D.E. , Gerrelli D. , Murdoch J.N. , Anderson R.H. , Copp A.J.
Circ. Res.89:6-12(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISEASE
5.

"Identification of Vangl2 and Scrb1 as planar polarity genes in mammals."
Montcouquiol M. , Rachel R.A. , Lanford P.J. , Copeland N.G. , Jenkins N.A. , Kelley M.W.
Nature423:173-177(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
6.

"Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family."
Torban E. , Wang H.-J. , Groulx N. , Gros P.
J. Biol. Chem.279:52703-52713(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DVL1; DVL2 AND DVL3
7.

"MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap."
Yao R. , Natsume Y. , Noda T.
Oncogene23:6023-6030(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAGI3
8.

"Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract."
Phillips H.M. , Murdoch J.N. , Chaudhry B. , Copp A.J. , Henderson D.J.
Circ. Res.96:292-299(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DEVELOPMENTAL STAGE
9.

"The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells."
Wang Y. , Guo N. , Nathans J.
J. Neurosci.26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals."
Montcouquiol M. , Sans N. , Huss D. , Kach J. , Dickman J.D. , Forge A. , Rachel R.A. , Copeland N.G. , Jenkins N.A. , Bogani D. , Murdoch J. , Warchol M.E. , Wenthold R.J. , Kelley M.W.
J. Neurosci.26:5265-5275(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FZD3 AND SCRIB;TISSUE SPECIFICITY
11.

"Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes."
Belotti E. , Puvirajesinghe T.M. , Audebert S. , Baudelet E. , Camoin L. , Pierres M. , Lasvaux L. , Ferracci G. , Montcouquiol M. , Borg J.P.
PLoS ONE7:E46213-E46213(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT

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