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Index > Protein center > ADRB1(Gene name) > Human
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  • ADRB1 (Gene name),
  • Beta-1 adrenergic receptor (Protein name ),  ADRB1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ADRB1(ADRB1R;B1AR);
    Protein name:
    Beta-1 adrenergic receptor;
    Alternative:
    Beta-1 adrenoreceptor(Beta-1 adrenoceptor);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GOPC, MAGI3 and DLG4.
    Function:
    Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.
    Protein Attributes:
    Sequence length:
    477
    Sequence:
    50:
    MGAGVLVLGA | SEPGNLSSAA | PLPDGAATAA | RLLVPASPPA | SLLPPASESP | 
    100:
    EPLSQQWTAG | MGLLMALIVL | LIVAGNVLVI | VAIAKTPRLQ | TLTNLFIMSL | 
    150:
    ASADLVMGLL | VVPFGATIVV | WGRWEYGSFF | CELWTSVDVL | CVTASIETLC | 
    200:
    VIALDRYLAI | TSPFRYQSLL | TRARARGLVC | TVWAISALVS | FLPILMHWWR | 
    250:
    AESDEARRCY | NDPKCCDFVT | NRAYAIASSV | VSFYVPLCIM | AFVYLRVFRE | 
    300:
    AQKQVKKIDS | CERRFLGGPA | RPPSPSPSPV | PAPAPPPGPP | RPAAAAATAP | 
    350:
    LANGRAGKRR | PSRLVALREQ | KALKTLGIIM | GVFTLCWLPF | FLANVVKAFH | 
    400:
    RELVPDRLFV | FFNWLGYANS | AFNPIIYCRS | PDFRKAFQRL | LCCARRAARR | 
    450:
    RHATHGDRPR | ASGCLARPGP | PPSPGAASDD | DDDDVVGATP | PARLLEPWAG | 
    477:
    CNGGAAADSD | SSLDEPCRPG | FASESKV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    MIM:
    Pfam:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653m
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    MSDS:
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    96T
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    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653p
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    96T
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    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    E10653d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Beta-1 adrenergic receptor
    Cat.:
    U10653p
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Cat.:
    P10653Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Cat.:
    P10653Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Polyclonal Antibody for Human Beta-1 adrenergic receptor
    Cat.:
    P10653Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Monoclonal Antibody for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor
    Protein for Human Beta-1 adrenergic receptor

    R&D Technical Data
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.3%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.1%

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    Recovery
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    Recovery was determined by spiking various levels of ADRB1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    95

    90-103

    Plasma

    97

    92-105

     

     

     

     

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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ADRB1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    90-102%

    91-100%

    88-103%

    92-99%

    EDTA plasma(n=5)

    92-101%

    93-103%

    89-106%

    90-106%

    heparin plasma(n=5)

    89-106%

     

    94-100%

    91-105%

    93-101%

     

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    2. 2.
      "Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C."
      Moore J.D. , Mason D.A. , Green S.A. , Hsu J. , Liggett S.B.
      Hum. Mutat.14:271-271(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-49 AND GLY-389
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2004-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-49; GLY-389 AND LEU-389
    4. 4.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-389
    6. 6.
      "Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation."
      Pak Y. , Pham N. , Rotin D.
      Mol. Cell. Biol.22:7942-7952(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAPGEF2;MUTAGENESIS OF SER-475 AND VAL-477
    7. 7.
      "Interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) inhibits beta1-adrenergic receptor surface expression."
      He J. , Bellini M. , Xu J. , Castleberry A.M. , Hall R.A.
      J. Biol. Chem.279:50190-50196(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GOPC AND DLG4;MUTAGENESIS OF GLU-474; SER-475; LYS-476 AND VAL-477;SUBCELLULAR LOCATION
    8. 8.
      "Down-modulation of the G-protein-coupled estrogen receptor, GPER, from the cell surface occurs via a trans-Golgi-proteasome pathway."
      Cheng S.B. , Quinn J.A. , Graeber C.T. , Filardo E.J.
      J. Biol. Chem.286:22441-22455(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor."
      Mason D.A. , Moore J.D. , Green S.A. , Liggett S.B.
      J. Biol. Chem.274:12670-12674(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-389
    10. 10.
      "A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure."
      Borjesson M. , Magnusson Y. , Hjalmarson A. , Andersson B.
      Eur. Heart J.21:1853-1858(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-49
    11. 11.
      "A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate."
      Ranade K. , Jorgenson E. , Sheu W.H.-H. , Pei D. , Hsiung C.A. , Chiang F.-T. , Chen Y.-D.I. , Pratt R. , Olshen R.A. , Curb D. , Cox D.R. , Botstein D. , Risch N.
      Am. J. Hum. Genet.70:935-942(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-49
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