CYR61 Protein for Human(Homo sapiens) | EIAab.comCYR61 Protein for Human(Homo sapiens)

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Index > Protein center > CYR61(Gene name) > Human

CYR61 (Gene name),

Protein CYR61 (Protein name ), CYR61_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CYR61(CCN1;GIG1;IGFBP10);

Protein name:

Protein CYR61;

Alternative:

Cysteine-rich angiogenic inducer 61;CCN family member 1;Protein GIG1;Insulin-like growth factor-binding protein 10(IBP-10;IGF-binding protein 10;IGFBP-10);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion. In skin fibroblasts it binds ITGA6/ITGB1, in endothelial cells, binds ITGAV/ITGB3 and in platelets, ITGA2B/ITGB3. Binds, in vitro, ITGAV/ITGB5.

Function:

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

381

Sequence:

50:

100:

150:

200:

250:

300:

350:

381:

QSCKCNYNCP | HANEAAFPFY | RLFNDIHKFR | D

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O00622

KEGG:

hsa:3491

Pfam:

PF00007

UniGene:

Hs.8867

MIM:

602369

String:

O00622

STRING:

9606.ENSP00000398736

Uniprot:

O00622

FOR

ELISA Kit for Human Protein CYR61

Cat.:

E0494r

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96T

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ELISA Kit for Human Protein CYR61

Cat.:

E0494m

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96T

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ELISA Kit for Human Protein CYR61

Cat.:

E0494h

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96T

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ELISA Kit for Human Protein CYR61

Cat.:

E0494c

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Packing:

96T

CLIA Kit for Human Protein CYR61

Cat.:

U0494h

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Manual:

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Packing:

96T

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CLIA Kit for Human Protein CYR61

Cat.:

U0494m

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MSDS:

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Packing:

96T

CLIA Kit for Human Protein CYR61

Cat.:

U0494c

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MSDS:

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Packing:

96T

CLIA Kit for Human Protein CYR61

Cat.:

U0494r

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96T

Polyclonal Antibody for Human Protein CYR61

Cat.:

P0494Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein CYR61

Cat.:

P0494Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein CYR61

Cat.:

P0494Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Protein CYR61

Monoclonal Antibody for Human Protein CYR61

Protein for Human Protein CYR61

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The human growth factor-inducible immediate early gene, CYR61, maps to chromosome 1p."
Jay P. , Berge-Lefranc J.-L. , Marsollier C. , Mejean C. , Taviaux S. , Berta P.
Oncogene14:1753-1757(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Chromosomal mapping and expression of the human cyr61 gene in tumour cells from the nervous system."
Martinerie C. , Viegas-Pequignot E. , Nguyen V.C. , Perbal B.
Mol. Pathol.50:310-316(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."
Albrecht C. , von Der Kammer H. , Mayhaus M. , Klaudiny J. , Schweizer M. , Nitsch R.M.
J. Biol. Chem.275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Human growth-factor inducible gene product CYR61, complete sequence."
Kolesnikova T.V. , Lau L.F.
Submitted (1997-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
5.

"Cloning of HumCyr61 gene expressing down-regulatedly in rhabdomyosarcoma."
Bi A.B. , Yu L.
Submitted (1997-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Regulation of hCYR61 by vitamin D, serum and cytokines in fetal human osteoblasts."
Schuetze N. , Lechner A. , Groll C. , Koehrle J. , Jakob F.
Submitted (1997-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
7.

"Organization and expression of the Cyr61 gene in normal human fibroblasts."
Leng E. , Malcolm T. , Tai G. , Estable M. , Sadowski I.
J. Biomed. Sci.9:59-67(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

NIEHS SNPs program
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT TRP-334
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
tissue: Placenta.
tissue: Skin.
10.

"The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts."
Chen C.-C. , Mo F.-E. , Lau L.F.
J. Biol. Chem.276:47329-47337(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN WOUND HEALING
11.

"Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3."
Kireeva M.L. , Lam S.C. , Lau L.F.
J. Biol. Chem.273:3090-3096(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-3
12.

"Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)."
Jedsadayanmata A. , Chen C.-C. , Kireeva M.L. , Lau L.F. , Lam S.C.
J. Biol. Chem.274:24321-24327(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-IIB/BETA-3
13.

"Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans."
Chen N. , Chen C.-C. , Lau L.F.
J. Biol. Chem.275:24953-24961(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-6/BETA-1
14.

"CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain."
Grzeszkiewicz T.M. , Kirschling D.J. , Chen N. , Lau L.F.
J. Biol. Chem.276:21943-21950(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INTEGRIN ALPHA-V/BETA-6

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