MPO Protein for Human(Homo sapiens) | EIAab.comMPO Protein for Human(Homo sapiens)

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MPO (Gene name),

Myeloperoxidase (Protein name ), PERM_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (2)

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Gene name:

MPO;

Protein name:

Myeloperoxidase(MPO);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.

Function:

Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

Subcellular Location:

Lysosome

Protein Attributes:

Sequence length:

745

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

745:

RIICDNTGIT | TVSKNNIFMS | NSYPRDFVNC | STLPALNLAS | WREAS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:4353

UniGene:

Hs.458272

SMR:

P05164

String:

P05164

STRING:

9606.ENSP00000225275

MIM:

254600

Pfam:

PF03098

Uniprot:

P05164

FOR

ELISA Kit for Human MPO

Cat.:

E0601h

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Packing:

96T

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ELISA Kit for Human MPO

Cat.:

E0601m

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Packing:

96T

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ELISA Kit for Human MPO

Cat.:

E0601r

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96T

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CLIA Kit for Human MPO

Cat.:

U0601r

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Looking for manual.

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Packing:

96T

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CLIA Kit for Human MPO

Cat.:

U0601m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human MPO

Cat.:

U0601h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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Polyclonal Antibody for Human MPO

Cat.:

P0601Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MPO

Cat.:

P0601Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human MPO

Cat.:

P0601Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human MPO

Protein for Human MPO

Cat.:

R0601h

Price:

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Packing:

1mg

Purity:

>90%

Protein for Human MPO

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Explosive type of moderate-resistance training induces functional, cardiovascular, and molecular adaptations in the elderly"

MRB Valls, I Dimauro, A Brunelli, et al.

From:Age

[2].

"Resistance training and redox homeostasis: Correlation with age-associated genomic changes"

Ivan D, Mattia S, Cristina F, et al.

From:Redox Biology

References

1.

"Molecular cloning and characterization of cDNA for human myeloperoxidase."
Morishita K. , Kubota N. , Asano S. , Kaziro Y. , Nagata S.
J. Biol. Chem.262:3844-3851(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H17)
2.

"Chromosomal gene structure of human myeloperoxidase and regulation of its expression by granulocyte colony-stimulating factor."
Morishita K. , Tsuchiya M. , Asano S. , Kaziro Y. , Nagata S.
J. Biol. Chem.262:15208-15213(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Isolation of a complementary DNA clone for thyroid microsomal antigen. Homology with the gene for thyroid peroxidase."
Seto P. , Hirayu H. , Magnusson R.P. , Gestautas J. , Portmann L. , Degroot L.J. , Rapoport B.
J. Clin. Invest.80:1205-1208(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H17)
4.

"Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species."
Johnson K.R. , Nauseef W.M. , Care A. , Wheelock M.J. , Shane S. , Hudson S. , Koeffler H.P. , Selsted M. , Miller C. , Rovera G.
Nucleic Acids Res.15:2013-2028(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H17)
5.

"Multiple species of myeloperoxidase messenger RNAs produced by alternative splicing and differential polyadenylation."
Hashinaka K. , Nishio C. , Hur S.-J. , Sakiyama F. , Tsunasawa S. , Yamada M.
Biochemistry27:5906-5914(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS H7; H14 AND H17);PROTEIN SEQUENCE OF 165-183; 216-222; 295-304; 311-331; 464-479; 662-676 AND 766-776
tissue: Leukemia.
6.

Hashinaka K. , Nishio C. , Hur S.-J. , Sakiyama F. , Tsunasawa S. , Yamada M.
Biochemistry27:9226-9226(1988)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
7.

"Complete nucleotide sequence of the human myeloperoxidase gene."
Johnson K.R. , Gemperlein I. , Hudson S. , Shane S. , Rovera G.
Nucleic Acids Res.17:7985-7986(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"Cloning and characterization of four types of cDNA encoding myeloperoxidase from human monocytic leukemia cell line, SKM-1."
Hosokawa Y. , Kawaguchi R. , Hikiji K. , Yamada M. , Suzuki K. , Nakagawa T. , Yoshihara T. , Yamaguchi K.
Leukemia7:441-445(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM H17)
9.

NIEHS SNPs program
Submitted (2005-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS PHE-53; CYS-604; GLN-683 AND VAL-717
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM H17)
12.

"Isolation and characterization of extracellular myeloperoxidase precursor in HL-60 cell cultures."
Yamada M. , Hur S.-J. , Toda H.
Biochem. Biophys. Res. Commun.166:852-859(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 49-66
13.

"Glycosylation pattern of mature dimeric leukocyte and recombinant monomeric myeloperoxidase: glycosylation is required for optimal enzymatic activity."
Van Antwerpen P. , Slomianny M.C. , Boudjeltia K.Z. , Delporte C. , Faid V. , Calay D. , Rousseau A. , Moguilevsky N. , Raes M. , Vanhamme L. , Furtmueller P.G. , Obinger C. , Vanhaeverbeek M. , Neve J. , Michalski J.C.
J. Biol. Chem.285:16351-16359(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 49-53;SUBUNIT;GLYCOSYLATION AT ASN-323; ASN-355; ASN-391; ASN-483 AND ASN-729;IDENTIFICATION BY MASS SPECTROMETRY
14.

"Unique autolytic cleavage of human myeloperoxidase. Implications for the involvement of active site MET409."
Taylor K.L. , Pohl J. , Kinkade J.M. Jr.
J. Biol. Chem.267:25282-25288(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 279-424
tissue: Leukocyte.
15.

"Identification of transcriptional cis-elements in introns 7 and 9 of the myeloperoxidase gene."
Yamada M. , Yoshida M. , Hashinaka K.
J. Biol. Chem.268:13479-13485(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 548-629
16.

"Isolation and characterization of a cDNA coding for human myeloperoxidase."
Yamada M. , Hur S.-J. , Hashinaka K. , Tsuneoka K. , Saeki T. , Nishio C. , Sakiyama F. , Tsunasawa S.
Arch. Biochem. Biophys.255:147-155(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 588-745
17.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-139 AND ASN-483
tissue: Plasma.
18.

"Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
Ramachandran P. , Boontheung P. , Xie Y. , Sondej M. , Wong D.T. , Loo J.A.
J. Proteome Res.5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-323 AND ASN-483
tissue: Saliva.
19.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-355 AND ASN-391
tissue: Liver.
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"X-ray crystal structure and characterization of halide-binding sites of human myeloperoxidase at 1.8-A resolution."
Fiedler T.J. , Davey C.A. , Fenna R.E.
J. Biol. Chem.275:11964-11971(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 167-744;SUBUNIT
22.

"Structure of the green heme in myeloperoxidase."
Fenna R.E. , Zeng J. , Davey C.
Arch. Biochem. Biophys.316:653-656(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 167-744;OXIDATION AT CYS-316
23.

"Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution."
Blair-Johnson M. , Fiedler T. , Fenna R.
Biochemistry40:13990-13997(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 167-744
24.

"Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency."
Kizaki M. , Miller C.W. , Selsted M.E. , Koeffler H.P.
Blood83:1935-1940(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPOD TRP-569
25.

"Hereditary myeloperoxidase deficiency due to a missense mutation of arginine 569 to tryptophan."
Nauseef W.M. , Brigham S. , Cogley M.
J. Biol. Chem.269:1212-1216(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPOD TRP-569
26.

"Effect of the R569W missense mutation on the biosynthesis of myeloperoxidase."
Nauseef W. , Cogley M. , McCormick S.
J. Biol. Chem.271:9546-9549(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT MPOD TRP-569
27.

"A novel form of hereditary myeloperoxidase deficiency linked to endoplasmic reticulum/proteasome degradation."
DeLeo F.R. , Goedken M. , McCormick S.J. , Nauseef W.M.
J. Clin. Invest.101:2900-2909(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPOD CYS-173;CHARACTERIZATION OF VARIANT MPOD CYS-173
28.

"Biochemical and molecular characterization of hereditary myeloperoxidase deficiency."
Romano M. , Dri P. , Dadalt L. , Patriarca P. , Baralle F.E.
Blood90:4126-4134(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MPOD THR-251
29.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-447

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