Protein name:
Metalloproteinase inhibitor 2 ;
Alternative:
Tissue inhibitor of metalloproteinases 2 (TIMP-2) ;CSC-21K ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via the C-terminal) with MMP2 (via the C-terminal PEX domain); the interaction inhibits the MMP2 activity.
Function:
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGAAARTLRL | ALGLLLLATL | LRPADACSCS | PVHPQQAFCN | ADVVIRAKAV |
100:
SEKEVDSGND | IYGNPIKRIQ | YEIKQIKMFK | GPEKDIEFIY | TAPSSAVCGV |
150:
SLDVGGKKEY | LIAGKAEGDG | KMHITLCDFI | VPWDTLSTTQ | KKSLNHRYQM |
200:
GCECKITRCP | MIPCYISSPD | ECLWMDWVTE | KNINGHQAKF | FACIKRSDGS |
220:
CAWYRGAAPP | KQEFLDIEDP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Chicken
Dog
Bovine
Rabbit
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
ELISA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
CLIA Kit for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Polyclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Monoclonal Antibody for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
Protein for Human Metalloproteinase inhibitor 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];INDUCTION
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Placenta .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Placenta .
tissue :
Skin .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 30-214
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-219;FUNCTION
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-219
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 30-51; 124-141 AND 159-173;FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 27-41
tissue :
Synovial fluid .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-50
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MMP2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MMP2;FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 27-153
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 27-153
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 27-220
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) IN COMPLEX WITH MMP-2;DISULFIDE BOND