Gene name:
UBR4(KIAA0462;KIAA1307;RBAF600;ZUBR1);
Protein name:
E3 ubiquitin-protein ligase UBR4;
Alternative:
N-recognin-4;600 kDa retinoblastoma protein-associated factor;Zinc finger UBR1-type protein 1;Retinoblastoma-associated factor of 600 kDa(RBAF600;p600);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with RB1 and calmodulin. Interacts with protein E7 from papilloma virus HPV-16, HPV-6B and HPV-11.
Function:
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Together with clathrin, forms meshwork structures involved in membrane morphogenesis and cytoskeletal organization. Regulates integrin-mediated signaling. May play a role in activation of FAK in response to cell-matrix interactions.
Subcellular Location:
Membrane
Multi-pass membrane protein
Cytoplasm
Cytoplasm
cytoskeleton
Nucleus
Concentrates at the leading edge of membrane structures involved in actin motility.
Protein Attributes:
50:
MATSGGEEAA | AAAPAPGTPA | TGADTTPGWE | VAVRPLLSAS | YSAFEMKELP |
100:
QLVASVIESE | SEILHHEKQY | EPFYSSFVAL | STHYITTVCS | LIPRNQLQSV |
150:
AAACKVLIEF | SLLRLENPDE | ACAVSQKHLI | LLIKGLCTGC | SRLDRTEIIT |
200:
FTAMMKSAKL | PQTVKTLSDV | EDQKELASPV | SPELRQKEVQ | MNFLNQLTSV |
250:
FNPRTVASQP | ISTQTLVEGE | NDEQSSTDQA | SAIKTKNVFI | AQNVASLQEL |
300:
GGSEKLLRVC | LNLPYFLRYI | NRFQDAVLAN | SFFIMPATVA | DATAVRNGFH |
350:
SLVIDVTMAL | DTLSLPVLEP | LNPSRLQDVT | VLSLSCLYAG | VSVATCMAIL |
400:
HVGSAQQVRT | GSTSSKEDDY | ESDAATIVQK | CLEIYDMIGQ | AISSSRRAGG |
450:
EHYQNFQLLG | AWCLLNSLFL | ILNLSPTALA | DKGKEKDPLA | ALRVRDILSR |
500:
TKEGVGSPKL | GPGKGHQGFG | VLSVILANHA | IKLLTSLFQD | LQVEALHKGW |
550:
ETDGPPAALS | IMAQSTSIQR | IQRLIDSVPL | MNLLLTLLST | SYRKACVLQR |
600:
QRKGSMSSDA | SASTDSNTYY | EDDFSSTEED | SSQDDDSEPI | LGQWFEETIS |
650:
PSKEKAAPPP | PPPPPPLESS | PRVKSPSKQA | PGEKGNILAS | RKDPELFLGL |
700:
ASNILNFITS | SMLNSRNNFI | RNYLSVSLSE | HHMATLASII | KEVDKDGLKG |
750:
SSDEEFAAAL | YHFNHSLVTS | DLQSPNLQNT | LLQQLGVAPF | SEGPWPLYIH |
800:
PQSLSVLSRL | LLIWQHKASA | QGDPDVPECL | KVWDRFLSTM | KQNALQGVVP |
850:
SETEDLNVEH | LQMLLLIFHN | FTETGRRAIL | SLFVQIIQEL | SVNMDAQMRF |
900:
VPLILARLLL | IFDYLLHQYS | KAPVYLFEQV | QHNLLSPPFG | WASGSQDSNS |
950:
RRATTPLYHG | FKEVEENWSK | HFSSDAVPHP | RFYCVLSPEA | SEDDLNRLDS |
1000:
VACDVLFSKL | VKYDELYAAL | TALLAAGSQL | DTVRRKENKN | VTALEACALQ |
1050:
YYFLILWRIL | GILPPSKTYI | NQLSMNSPEM | SECDILHTLR | WSSRLRISSY |
1100:
VNWIKDHLIK | QGMKAEHASS | LLELASTTKC | SSVKYDVEIV | EEYFARQISS |
1150:
FCSIDCTTIL | QLHEIPSLQS | IYTLDAAISK | VQVSLDEHFS | KMAAETDPHK |
1200:
SSEITKNLLP | ATLQLIDTYA | SFTRAYLLQN | FNEEGTTEKP | SKEKLQGFAA |
1250:
VLAIGSSRCK | ANTLGPTLVQ | NLPSSVQTVC | ESWNNINTNE | FPNIGSWRNA |
1300:
FANDTIPSES | YISAVQAAHL | GTLCSQSLPL | AASLKHTLLS | LVRLTGDLIV |
1350:
WSDEMNPPQV | IRTLLPLLLE | SSTESVAEIS | SNSLERILGP | AESDEFLARV |
1400:
YEKLITGCYN | ILANHADPNS | GLDESILEEC | LQYLEKQLES | SQARKAMEEF |
1450:
FSDSGELVQI | MMATANENLS | AKFCNRVLKF | FTKLFQLTEK | SPNPSLLHLC |
1500:
GSLAQLACVE | PVRLQAWLTR | MTTSPPKDSD | QLDVIQENRQ | LLQLLTTYIV |
1550:
RENSQVGEGV | CAVLLGTLTP | MATEMLANGD | GTGFPELMVV | MATLASAGQG |
1600:
AGHLQLHNAA | VDWLSRCKKY | LSQKNVVEKL | NANVMHGKHV | MILECTCHIM |
1650:
SYLADVTNAL | SQSNGQGPSH | LSVDGEERAI | EVDSDWVEEL | AVEEEDSQAE |
1700:
DSDEDSLCNK | LCTFTITQKE | FMNQHWYHCH | TCKMVDGVGV | CTVCAKVCHK |
1750:
DHEISYAKYG | SFFCDCGAKE | DGSCLALVKR | TPSSGMSSTM | KESAFQSEPR |
1800:
ISESLVRHAS | TSSPADKAKV | TISDGKVADE | EKPKKSSLCR | TVEGCREELQ |
1850:
NQANFSFAPL | VLDMLNFLMD | AIQTNFQQAS | AVGSSSRAQQ | ALSELHTVEK |
1900:
AVEMTDQLMV | PTLGSQEGAF | ENVRMNYSGD | QGQTIRQLIS | AHVLRRVAMC |
1950:
VLSSPHGRRQ | HLAVSHEKGK | ITVLQLSALL | KQADSSKRKL | TLTRLASAPV |
2000:
PFTVLSLTGN | PCKEDYLAVC | GLKDCHVLTF | SSSGSVSDHL | VLHPQLATGN |
2050:
FIIKAVWLPG | SQTELAIVTA | DFVKIYDLCV | DALSPTFYFL | LPSSKIRDVT |
2100:
FLFNEEGKNI | IVIMSSAGYI | YTQLMEEASS | AQQGPFYVTN | VLEINHEDLK |
2150:
DSNSQVAGGG | VSVYYSHVLQ | MLFFSYCQGK | SFAATISRTT | LEVLQLFPIN |
2200:
IKSSNGGSKT | SPALCQWSEV | MNHPGLVCCV | QQTTGVPLVV | MVKPDTFLIQ |
2250:
EIKTLPAKAK | IQDMVAIRHT | ACNEQQRTTM | ILLCEDGSLR | IYMANVENTS |
2300:
YWLQPSLQPS | SVISIMKPVR | KRKTATITTR | TSSQVTFPID | FFEHNQQLTD |
2350:
VEFGGNDLLQ | VYNAQQIKHR | LNSTGMYVAN | TKPGGFTIEI | SNNNSTMVMT |
2400:
GMRIQIGTQA | IERAPSYIEI | FGRTMQLNLS | RSRWFDFPFT | REEALQADKK |
2450:
LNLFIGASVD | PAGVTMIDAV | KIYGKTKEQF | GWPDEPPEEF | PSASVSNICP |
2500:
SNLNQSNGTG | DSDSAAPTTT | SGTVLERLVV | SSLEALESCF | AVGPIIEKER |
2550:
NKNAAQELAT | LLLSLPAPAS | VQQQSKSLLA | SLHTSRSAYH | SHKDQALLSK |
2600:
AVQCLNTSSK | EGKDLDPEVF | QRLVITARSI | AIMRPNNLVH | FTESKLPQME |
2650:
TEGMDEGKEP | QKQLEGDCCS | FITQLVNHFW | KLHASKPKNA | FLAPACLPGL |
2700:
THIEATVNAL | VDIIHGYCTC | ELDCINTASK | IYMQMLLCPD | PAVSFSCKQA |
2750:
LIRVLRPRNK | RRHVTLPSSP | RSNTPMGDKD | DDDDDDADEK | MQSSGIPNGG |
2800:
HIRQESQEQS | EVDHGDFEMV | SESMVLETAE | NVNNGNPSPL | EALLAGAEGF |
2850:
PPMLDIPPDA | DDETMVELAI | ALSLQQDQQG | SSSSALGLQS | LGLSGQAPSS |
2900:
SSLDAGTLSD | TTASAPASDD | EGSTAATDGS | TLRTSPADHG | GSVGSESGGS |
2950:
AVDSVAGEHS | VSGRSSAYGD | ATAEGHPAGP | GSVSSSTGAI | STTTGHQEGD |
3000:
GSEGEGEGET | EGDVHTSNRL | HMVRLMLLER | LLQTLPQLRN | VGGVRAIPYM |
3050:
QVILMLTTDL | DGEDEKDKGA | LDNLLSQLIA | ELGMDKKDVS | KKNERSALNE |
3100:
VHLVVMRLLS | VFMSRTKSGS | KSSICESSSL | ISSATAAALL | SSGAVDYCLH |
3150:
VLKSLLEYWK | SQQNDEEPVA | TSQLLKPHTT | SSPPDMSPFF | LRQYVKGHAA |
3200:
DVFEAYTQLL | TEMVLRLPYQ | IKKITDTNSR | IPPPVFDHSW | FYFLSEYLMI |
3250:
QQTPFVRRQV | RKLLLFICGS | KEKYRQLRDL | HTLDSHVRGI | KKLLEEQGIF |
3300:
LRASVVTASS | GSALQYDTLI | SLMEHLKACA | EIAAQRTINW | QKFCIKDDSV |
3350:
LYFLLQVSFL | VDEGVSPVLL | QLLSCALCGS | KVLAALAASS | GSSSASSSSA |
3400:
PVAASSGQAT | TQSKSSTKKS | KKEEKEKEKD | GETSGSQEDQ | LCTALVNQLN |
3450:
KFADKETLIQ | FLRCFLLESN | SSSVRWQAHC | LTLHIYRNSS | KSQQELLLDL |
3500:
MWSIWPELPA | YGRKAAQFVD | LLGYFSLKTP | QTEKKLKEYS | QKAVEILRTQ |
3550:
NHILTNHPNS | NIYNTLSGLV | EFDGYYLESD | PCLVCNNPEV | PFCYIKLSSI |
3600:
KVDTRYTTTQ | QVVKLIGSHT | ISKVTVKIGD | LKRTKMVRTI | NLYYNNRTVQ |
3650:
AIVELKNKPA | RWHKAKKVQL | TPGQTEVKID | LPLPIVASNL | MIEFADFYEN |
3700:
YQASTETLQC | PRCSASVPAN | PGVCGNCGEN | VYQCHKCRSI | NYDEKDPFLC |
3750:
NACGFCKYAR | FDFMLYAKPC | CAVDPIENEE | DRKKAVSNIN | TLLDKADRVY |
3800:
HQLMGHRPQL | ENLLCKVNEA | APEKPQDDSG | TAGGISSTSA | SVNRYILQLA |
3850:
QEYCGDCKNS | FDELSKIIQK | VFASRKELLE | YDLQQREAAT | KSSRTSVQPT |
3900:
FTASQYRALS | VLGCGHTSST | KCYGCASAVT | EHCITLLRAL | ATNPALRHIL |
3950:
VSQGLIRELF | DYNLRRGAAA | MREEVRQLMC | LLTRDNPEAT | QQMNDLIIGK |
4000:
VSTALKGHWA | NPDLASSLQY | EMLLLTDSIS | KEDSCWELRL | RCALSLFLMA |
4050:
VNIKTPVVVE | NITLMCLRIL | QKLIKPPAPT | SKKNKDVPVE | ALTTVKPYCN |
4100:
EIHAQAQLWL | KRDPKASYDA | WKKCLPIRGI | DGNGKAPSKS | ELRHLYLTEK |
4150:
YVWRWKQFLS | RRGKRTSPLD | LKLGHNNWLR | QVLFTPATQA | ARQAACTIVE |
4200:
ALATIPSRKQ | QVLDLLTSYL | DELSIAGECA | AEYLALYQKL | ITSAHWKVYL |
4250:
AARGVLPYVG | NLITKEIARL | LALEEATLST | DLQQGYALKS | LTGLLSSFVE |
4300:
VESIKRHFKS | RLVGTVLNGY | LCLRKLVVQR | TKLIDETQDM | LLEMLEDMTT |
4350:
GTESETKAFM | AVCIETAKRY | NLDDYRTPVF | IFERLCSIIY | PEENEVTEFF |
4400:
VTLEKDPQQE | DFLQGRMPGN | PYSSNEPGIG | PLMRDIKNKI | CQDCDLVALL |
4450:
EDDSGMELLV | NNKIISLDLP | VAEVYKKVWC | TTNEGEPMRI | VYRMRGLLGD |
4500:
ATEEFIESLD | STTDEEEDEE | EVYKMAGVMA | QCGGLECMLN | RLAGIRDFKQ |
4550:
GRHLLTVLLK | LFSYCVKVKV | NRQQLVKLEM | NTLNVMLGTL | NLALVAEQES |
4600:
KDSGGAAVAE | QVLSIMEIIL | DESNAEPLSE | DKGNLLLTGD | KDQLVMLLDQ |
4650:
INSTFVRSNP | SVLQGLLRII | PYLSFGEVEK | MQILVERFKP | YCNFDKYDED |
4700:
HSGDDKVFLD | CFCKIAAGIK | NNSNGHQLKD | LILQKGITQN | ALDYMKKHIP |
4750:
SAKNLDADIW | KKFLSRPALP | FILRLLRGLA | IQHPGTQVLI | GTDSIPNLHK |
4800:
LEQVSSDEGI | GTLAENLLEA | LREHPDVNKK | IDAARRETRA | EKKRMAMAMR |
4850:
QKALGTLGMT | TNEKGQVVTK | TALLKQMEEL | IEEPGLTCCI | CREGYKFQPT |
4900:
KVLGIYTFTK | RVALEEMENK | PRKQQGYSTV | SHFNIVHYDC | HLAAVRLARG |
4950:
REEWESAALQ | NANTKCNGLL | PVWGPHVPES | AFATCLARHN | TYLQECTGQR |
5000:
EPTYQLNIHD | IKLLFLRFAM | EQSFSADTGG | GGRESNIHLI | PYIIHTVLYV |
5050:
LNTTRATSRE | EKNLQGFLEQ | PKEKWVESAF | EVDGPYYFTV | LALHILPPEQ |
5100:
WRATRVEILR | RLLVTSQARA | VAPGGATRLT | DKAVKDYSAY | RSSLLFWALV |
5150:
DLIYNMFKKV | PTSNTEGGWS | CSLAEYIRHN | DMPIYEAADK | ALKTFQEEFM |
5183:
PVETFSEFLD | VAGLLSEITD | PESFLKDLLN | SVP
Vaild Sequence:
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