PLAU Protein for Human(Homo sapiens) | EIAab.comPLAU Protein for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > PLAU(Gene name) > Human

PLAU (Gene name),

Urokinase-type plasminogen activator (Protein name ), UROK_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

PLAU;

Protein name:

Urokinase-type plasminogen activator(U-plasminogen activator;uPA);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Found in high and low molecular mass forms. Each consists of two chains, A and B. The high molecular mass form contains a long chain A which is cleaved to yield a short chain A. Binds LRP1B; binding is followed by internalization and degradation. Interacts with MRC2. Interacts with PLAUR.

Function:

Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

431

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

431:

ALKDKPGVYT | RVSHFLPWIR | SHTKEENGLA | L

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.77274

MIM:

191840

String:

P00749

SMR:

P00749

KEGG:

hsa:5328

Pfam:

PF00051

STRING:

9606.ENSP00000361850

Uniprot:

P00749

FOR

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140b

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140c

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140p

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

Cat.:

E0140r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human U-plasminogen activator

MSDS:

Please sign in first.

CLIA Kit for Human U-plasminogen activator

MSDS:

Please sign in first.

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140p

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140c

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human U-plasminogen activator

Cat.:

U0140b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human U-plasminogen activator

Cat.:

P0140Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human U-plasminogen activator

Cat.:

P0140Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human U-plasminogen activator

Cat.:

P0140Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human U-plasminogen activator

Monoclonal Antibody for Human U-plasminogen activator

Protein for Human U-plasminogen activator

Cat.:

R0140h

Price:

Please sign in first.

Packing:

1mg

Purity:

>90%

Protein for Human U-plasminogen activator

Cat.:

R0140m

Price:

Please sign in first.

Packing:

1mg

Purity:

>90%

Protein for Human U-plasminogen activator

R&D Technical Data

12% SDS-PAGE analysis

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and expression of the gene for pro-urokinase in Escherichia coli."
Holmes W.E. , Pennica D. , Blaber M. , Rey M.W. , Guenzler W.A. , Steffens G.J. , Heyneker H.L.
Biotechnology (N.Y.)3:923-929(1985)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Molecular cloning, sequencing, and expression in Escherichia coli of human preprourokinase cDNA."
Jacobs P. , Cravador A. , Loriau R. , Brockly F. , Colau B. , Chuchana P. , van Elsen A. , Herzog A. , Bollen A.
DNA4:139-146(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Molecular cloning of cDNA coding for human preprourokinase."
Nagai M. , Hiramatsu R. , Kaneda T. , Hayasuke N. , Arimura H. , Nishida M. , Suyama T.
Gene36:183-188(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.

"The human urokinase-plasminogen activator gene and its promoter."
Riccio A. , Grimaldi G. , Verde P. , Sebastio G. , Boast S. , Blasi F.
Nucleic Acids Res.13:2759-2771(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-214
5.

"Cloning of human full-length CDSs in BD Creator(TM) System Donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Mesangial cell.
7.

SeattleSNPs variation discovery resource
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-15; LEU-141 AND GLN-231
8.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-141
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
11.

"Characterization of single chain urokinase-type plasminogen activator with a novel amino-acid substitution in the kringle structure."
Yoshimoto M. , Ushiyama Y. , Sakai M. , Tamaki S. , Hara H. , Takahashi K. , Sawasaki Y. , Hanada K.
Biochim. Biophys. Acta1293:83-89(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-431;VARIANT LEU-141
12.

"Characterization of a posttranslational fucosylation in the growth factor domain of urinary plasminogen activator."
Buko A.M. , Kentzer E.J. , Petros A. , Menon G. , Zuiderweg E.R. , Sarin V.K.
Proc. Natl. Acad. Sci. U.S.A.88:3992-3996(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-43;GLYCOSYLATION AT THR-38;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Identification and primary sequence of an unspliced human urokinase poly(A)+ RNA."
Verde P. , Stoppelli M.P. , Galeffi P. , di Nocera P. , Blasi F.
Proc. Natl. Acad. Sci. U.S.A.81:4727-4731(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 66-431;VARIANT MET-214
14.

"The primary structure of high molecular mass urokinase from human urine. The complete amino acid sequence of the A chain."
Gunzler W.A. , Steffens G.J. , Otting F. , Kim S.-M.A. , Frankus E. , Flohe L.
Hoppe-Seyler's Z. Physiol. Chem.363:1155-1165(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-177
15.

"Human low-molecular-weight urinary urokinase. Partial characterization and preliminary sequence data of the two polypeptide chains."
Schaller J. , Nick H. , Rickli E.E. , Gillessen D. , Lergier W. , Studer R.O.
Eur. J. Biochem.125:251-257(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 156-176 AND 179-224
16.

"The complete amino acid sequence of low molecular mass urokinase from human urine."
Steffens G.J. , Gunzler W.A. , Otting F. , Frankus E. , Flohe L.
Hoppe-Seyler's Z. Physiol. Chem.363:1043-1058(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 158-410
17.

"Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for identity of PCI and plasminogen activator inhibitor 3."
Stief T.W. , Radtke K.P. , Heimburger N.
Biol. Chem. Hoppe-Seyler368:1427-1433(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
18.

"Phosphorylation of human pro-urokinase on Ser138/303 impairs its receptor-dependent ability to promote myelomonocytic adherence and motility."
Franco P. , Iaccarino C. , Chiaradonna F. , Brandazza A. , Iavarone C. , Mastronicola M.R. , Nolli M.L. , Stoppelli M.P.
J. Cell Biol.137:779-791(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-158 AND SER-323;MUTAGENESIS OF SER-158 AND SER-323
19.

"Functionally inactive protein C inhibitor in seminal plasma may be associated with infertility."
He S. , Lin Y.L. , Liu Y.X.
Mol. Hum. Reprod.5:513-519(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HETERODIMER WITH SERPINA5
20.

"A urokinase receptor-associated protein with specific collagen binding properties."
Behrendt N. , Jensen O.N. , Engelholm L.H. , Moertz E. , Mann M. , Danoe K.
J. Biol. Chem.275:1993-2002(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MRC2
21.

"The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein."
Liu C.-X. , Li Y. , Obermoeller-McCormick L.M. , Schwartz A.L. , Bu G.
J. Biol. Chem.276:28889-28896(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LRP1B
22.

"Regulation of carcinoma cell invasion by protein C inhibitor whose expression is decreased in renal cell carcinoma."
Wakita T. , Hayashi T. , Nishioka J. , Tamaru H. , Akita N. , Asanuma K. , Kamada H. , Gabazza E.C. , Ido M. , Kawamura J. , Suzuki K.
Int. J. Cancer108:516-523(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;HETERODIMER WITH SERPINA5
23.

"Platelet-derived growth factor D is activated by urokinase plasminogen activator in prostate carcinoma cells."
Ustach C.V. , Kim H.-R.C.
Mol. Cell. Biol.25:6279-6288(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
24.

"Persons with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene."
Paterson A.D. , Rommens J.M. , Bharaj B. , Blavignac J. , Wong I. , Diamandis M. , Waye J.S. , Rivard G.E. , Hayward C.P.
Blood115:1264-1266(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN QPD
25.

"Dynamics of the multidomain fibrinolytic protein urokinase from two-dimensional NMR."
Oswald R.E. , Bogusky M.J. , Bamberger M. , Smith R.A.G. , Dobson C.M.
Nature337:579-582(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
26.

"Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase."
Li X. , Smith R.A.G. , Dobson C.M.
Biochemistry31:9562-9571(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 67-155
27.

"Solution structure of the kringle domain from urokinase-type plasminogen activator."
Li X. , Bokman A.M. , Llinas M. , Smith R.A.G. , Dobson C.M.
J. Mol. Biol.235:1548-1559(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 67-155
28.

"The crystal structure of the catalytic domain of human urokinase-type plasminogen activator."
Spraggon G. , Phillips C. , Nowak U.K. , Ponting C.P. , Saunders D. , Dobson C.M. , Stuart D.I. , Jones E.Y.
Structure3:681-691(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
29.

"(4-aminomethyl)phenylguanidine derivatives as nonpeptidic highly selective inhibitors of human urokinase."
Sperl S. , Jacob U. , Arroyo de Prada N. , Sturzebecher J. , Wilhelm O.G. , Bode W. , Magdolen V. , Huber R. , Moroder L.
Proc. Natl. Acad. Sci. U.S.A.97:5113-5118(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 159-411
30.

"Structure of human urokinase plasminogen activator in complex with its receptor."
Huai Q. , Mazar A.P. , Kuo A. , Parry G.C. , Shaw D.E. , Callahan J. , Li Y. , Yuan C. , Bian C. , Chen L. , Furie B. , Furie B.C. , Cines D.B. , Huang M.
Science311:656-659(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 31-152 IN COMPLEX WITH PLAUR
31.

"Detection of polymorphisms in the human urokinase-type plasminogen activator gene."
Conne B. , Berczy M. , Belin D.
Thromb. Haemost.77:434-435(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-141
32.

Conne B. , Berczy M. , Belin D.
Thromb. Haemost.78:973-973(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
33.

"Mutational analysis of the genes encoding urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in advanced ovarian cancer."
Turkmen B. , Schmitt M. , Schmalfeldt B. , Trommler P. , Hell W. , Creutzburg S. , Graeff H. , Magdolen V.
Electrophoresis18:686-689(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-141
34.

"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J. , Mardis E.R. , Ding L. , Fulton B. , McLellan M.D. , Chen K. , Dooling D. , Dunford-Shore B.H. , McGrath S. , Hickenbotham M. , Cook L. , Abbott R. , Larson D.E. , Koboldt D.C. , Pohl C. , Smith S. , Hawkins A. , Abbott S. , more...
Nature456:66-72(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-141

Product Feedback Wall

* Email:
*Comments: