RAD51B ELISA Kit for Human(Homo sapiens) | EIAab.comRAD51B ELISA Kit for Human(Homo sapiens)

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RAD51B (Gene name),

DNA repair protein RAD51 homolog 2 (Protein name ), RA51B_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RAD51B(RAD51L1;REC2);

Protein name:

DNA repair protein RAD51 homolog 2(R51H2);

Alternative:

RAD51-like protein 1;RAD51 homolog B(Rad51B);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RAD51C. Part of a BCDX2 complex consisting of RAD51B, RAD51C, RAD51D and XRCC2. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3. Part of a complex with RAD51C and RAD51.

Function:

Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. The RAD51B-RAD51C dimer exhibits single-stranded DNA-dependent ATPase activity. The BCDX2 complex binds single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

384

Sequence:

50:

100:

150:

200:

250:

300:

350:

384:

SVTQAELNWA | PEILPPQPPE | QLGLQMCHHT | QLIF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08423

SMR:

O15315

UniGene:

Hs.172587

KEGG:

hsa:5890

String:

O15315

MIM:

150699

Uniprot:

O15315

FOR

ELISA Kit for Human R51H2

CLIA Kit for Human R51H2

Polyclonal Antibody for Human R51H2

Monoclonal Antibody for Human R51H2

Protein for Human R51H2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis."
Rice M.C. , Smith S.T. , Bullrich F. , Havre P. , Kmiec E.B.
Proc. Natl. Acad. Sci. U.S.A.94:7417-7422(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
2.

"Identification of a novel human RAD51 homolog, RAD51B."
Albala J.S. , Thelen M.P. , Prange C.K. , Fan W. , Christensen M. , Thompson L.H. , Lennon G.G.
Genomics46:476-479(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.

"Isolation of novel human and mouse genes of the recA/RAD51 recombination-repair gene family."
Cartwright R. , Dunn A.M. , Simpson P.J. , Tambini C.E. , Thacker J.
Nucleic Acids Res.26:1653-1659(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
4.

"Full-length cDNA libraries and normalization."
Li W.B. , Gruber C. , Jessee J. , Polayes D.
Submitted (2003-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5)
tissue: Neuroblastoma.
5.

NIEHS SNPs program
Submitted (2005-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-9; CYS-82; TRP-172; CYS-180; ARG-243 AND ALA-250
6.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
7.

"The DNA sequence and analysis of human chromosome 14."
Heilig R. , Eckenberg R. , Petit J.-L. , Fonknechten N. , Da Silva C. , Cattolico L. , Levy M. , Barbe V. , De Berardinis V. , Ureta-Vidal A. , Pelletier E. , Vico V. , Anthouard V. , Rowen L. , Madan A. , Qin S. , Sun H. , Du H. , more...
Nature421:601-607(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
10.

"Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15."
Quade B.J. , Weremowicz S. , Neskey D.M. , Vanni R. , Ladd C. , Dal Cin P. , Morton C.C.
Cancer Res.63:1351-1358(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 253-310;CHROMOSOMAL TRANSLOCATION WITH HMGA2
11.

"Identification and purification of two distinct complexes containing the five RAD51 paralogs."
Masson J.Y. , Tarsounas M.C. , Stasiak A.Z. , Stasiak A. , Shah R. , McIlwraith M.J. , Benson F.E. , West S.C.
Genes Dev.15:3296-3307(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE BCDX2 COMPLEX WITH RAD51C; RAD51D AND XRCC2
12.

"Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchange."
Sigurdsson S. , Van Komen S. , Bussen W. , Schild D. , Albala J.S. , Sung P.
Genes Dev.15:3308-3318(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RAD51C
13.

"Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells."
Liu N. , Schild D. , Thelen M.P. , Thompson L.H.
Nucleic Acids Res.30:1009-1015(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH RAD51C; RAD51D AND XRCC2
14.

"RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51."
Miller K.A. , Yoshikawa D.M. , McConnell I.R. , Clark R. , Schild D. , Albala J.S.
J. Biol. Chem.277:8406-8411(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51C;SUBUNIT
15.

"Interactions involving the Rad51 paralogs Rad51C and XRCC3 in human cells."
Wiese C. , Collins D.W. , Albala J.S. , Thompson L.H. , Kronenberg A. , Schild D.
Nucleic Acids Res.30:1001-1008(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH RAD51C; RAD51D AND XRCC2
16.

"Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro."
Lio Y.-C. , Mazin A.V. , Kowalczykowski S.C. , Chen D.J.
J. Biol. Chem.278:2469-2478(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51 AND RAD51C
17.

"Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas."
Schoenmakers E.F.P.M. , Huysmans C. , Van de Ven W.J.M.
Cancer Res.59:19-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH HMGA2
18.

"Intragenic breakpoint within RAD51L1 in a t(6;14)(p21.3;q24) of a pulmonary chondroid hamartoma."
Blank C. , Schoenmakers E.F.P.M. , Rogalla P. , Huys E.H. , van Rijk A.A. , Drieschner N. , Bullerdiek J.
Cytogenet. Cell Genet.95:17-19(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH HMGA1
19.

"Holliday junction binding activity of the human Rad51B protein."
Yokoyama H. , Kurumizaka H. , Ikawa S. , Yokoyama S. , Shibata T.
J. Biol. Chem.278:2767-2772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
20.

"Domain mapping of the Rad51 paralog protein complexes."
Miller K.A. , Sawicka D. , Barsky D. , Albala J.S.
Nucleic Acids Res.32:169-178(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51C
21.

"BCR/ABL kinase interacts with and phosphorylates the RAD51 paralog, RAD51B."
Slupianek A. , Jozwiakowski S.K. , Gurdek E. , Skorski T.
Leukemia23:2308-2310(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY BCR-ABL;MUTAGENESIS OF PRO-326
22.

"hSWS1.SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair."
Liu T. , Wan L. , Wu Y. , Chen J. , Huang J.
J. Biol. Chem.286:41758-41766(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SWSAP1
23.

"The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy."
Rodrigue A. , Coulombe Y. , Jacquet K. , Gagne J.P. , Roques C. , Gobeil S. , Poirier G. , Masson J.Y.
J. Cell Sci.126:348-359(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MITOTIC CELL PROGRESSION
24.

"Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway."
Chun J. , Buechelmaier E.S. , Powell S.N.
Mol. Cell. Biol.33:387-395(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE BCDX2 COMPLEX
25.

"Ring-shaped Rad51 paralog protein complexes bind Holliday junctions and replication forks as visualized by electron microscopy."
Compton S.A. , Ozgur S. , Griffith J.D.
J. Biol. Chem.285:13349-13356(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ELECTRON MICROSCOPY OF THE BCDX2 COMPLEX;DNA-BINDING OF THE BCDX2 COMPLEX

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