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Index > Protein center > CRABP2(Gene name) > Human
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  • CRABP2 (Gene name),
  • Cellular retinoic acid-binding protein 2 (Protein name ),  RABP2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CRABP2;
    Protein name:
    Cellular retinoic acid-binding protein 2;
    Alternative:
    Cellular retinoic acid-binding protein II(CRABP-II);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RXR and RARA (By similarity). Interacts with importin alpha.
    Function:
    Transports retinoic acid to the nucleus. Regulates the access of retinoic acid to the nuclear retinoic acid receptors.
    Subcellular Location:
    Cytoplasm Nucleus Upon ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus.
    Protein Attributes:
    Sequence length:
    138
    Sequence:
    50:
    MPNFSGNWKI | IRSENFEELL | KVLGVNVMLR | KIAVAAASKP | AVEIKQEGDT | 
    100:
    FYIKTSTTVR | TTEINFKVGE | EFEEQTVDGR | PCKSLVKWES | ENKMVCEQKL | 
    138:
    LKGEGPKTSW | TRELTNDGEL | ILTMTADDVV | CTRVYVRE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    SMR:
    KEGG:
    String:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cellular retinoic acid-binding protein 2
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    E0368h
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    ELISA Kit for Human Cellular retinoic acid-binding protein 2
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    E0368m
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    ELISA Kit for Human Cellular retinoic acid-binding protein 2
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    E0368c
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    ELISA Kit for Human Cellular retinoic acid-binding protein 2
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    E0368b
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    96T
    ELISA Kit for Human Cellular retinoic acid-binding protein 2
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    E0368r
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    CLIA Kit for Human Cellular retinoic acid-binding protein 2
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    U0368b
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    CLIA Kit for Human Cellular retinoic acid-binding protein 2
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    U0368m
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    CLIA Kit for Human Cellular retinoic acid-binding protein 2
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    U0368c
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    CLIA Kit for Human Cellular retinoic acid-binding protein 2
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    CLIA Kit for Human Cellular retinoic acid-binding protein 2
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    Packing:
    96T
    Polyclonal Antibody for Human Cellular retinoic acid-binding protein 2
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    P0368Rb-r
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    Polyclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Cat.:
    P0368Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Polyclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Polyclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Cat.:
    P0368Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Monoclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Monoclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Monoclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Monoclonal Antibody for Human Cellular retinoic acid-binding protein 2
    Protein for Human Cellular retinoic acid-binding protein 2
    Protein for Human Cellular retinoic acid-binding protein 2
    Protein for Human Cellular retinoic acid-binding protein 2
    Protein for Human Cellular retinoic acid-binding protein 2
    Protein for Human Cellular retinoic acid-binding protein 2

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    References
    1. 1.
      "Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro."
      Astroem A. , Tavakkol A. , Pettersson U. , Cromie M. , Elder J.T. , Voorhees J.J.
      J. Biol. Chem.266:17662-17666(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The molecular cloning and expression of two CRABP cDNAs from human skin."
      Eller M.S. , Oleksiak M.F. , McQuaid T.J. , McAfee S.G. , Gilchrest B.A.
      Exp. Cell Res.198:328-336(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid."
      Aastroem A. , Pettersson U. , Voorhees J.J.
      J. Biol. Chem.267:25251-25255(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    7. 7.
      "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."
      Oshikawa M. , Tsutsui C. , Ikegami T. , Fuchida Y. , Matsubara M. , Toyama S. , Usami R. , Ohtoko K. , Kato S.
      Invest. Ophthalmol. Vis. Sci.52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    11. 11.
      "Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest."
      Budhu A.S. , Noy N.
      Mol. Cell. Biol.22:2632-2641(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NUCLEAR RETINOIC ACID RECEPTORS
    12. 12.
      "A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II."
      Sessler R.J. , Noy N.
      Mol. Cell18:343-353(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-21; ARG-30 AND LYS-31
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation."
      Majumdar A. , Petrescu A.D. , Xiong Y. , Noy N.
      J. Biol. Chem.286:42749-42757(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-102
    15. 15.
      "Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid."
      Kleywegt G.J. , Bergfors T. , Senn H. , le Motte P. , Gsell B. , Shudo K. , Jones T.A.
      Structure2:1241-1258(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
    16. 16.
      "Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry."
      Chen X. , Tordova M. , Gilliland G.L. , Wang L. , Li Y. , Yan H. , Ji X.
      J. Mol. Biol.278:641-653(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
    17. 17.
      "Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids."
      Chaudhuri B.N. , Kleywegt G.J. , Broutin-L'Hermite I. , Bergfors T. , Senn H. , Le Motte P. , Partouche O. , Jones T.A.
      Acta Crystallogr. D55:1850-1857(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)
    18. 18.
      "NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding."
      Wang L. , Li Y. , Abildgaard F. , Markley J.L. , Yan H.
      Biochemistry37:12727-12736(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    19. 19.
      "NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein."
      Wang L. , Yan H.
      Biochemistry37:13021-13032(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    20. 20.
      "The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation."
      Vaezeslami S. , Mathes E. , Vasileiou C. , Borhan B. , Geiger J.H.
      J. Mol. Biol.363:687-701(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS)
    21. 21.
      "Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic."
      Vasileiou C. , Vaezeslami S. , Crist R.M. , Rabago-Smith M. , Geiger J.H. , Borhan B.
      J. Am. Chem. Soc.129:6140-6148(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.18 ANGSTROMS) IN COMPLEX WITH RETINOIC ACID
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