Cell cycle checkpoint protein RAD17 (Protein name
), RAD17_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
RAD17(R24L);
Protein name:
Cell cycle checkpoint protein RAD17(hRad17);
Alternative:
RF-C/activator 1 homolog;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Part of a DNA-binding complex containing RFC2, RFC3, RFC4 and RFC5. Interacts with RAD1 and RAD9 within the RAD1-RAD9-HUS1 complex. Interacts with RAD9B, POLE, NHP2L1 and MCM7. DNA damage promotes interaction with ATR or ATM and disrupts interaction with the RAD1-RAD9-HUS1 complex.
Function:
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9-HUS1 complex and C12orf32/RHINO onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Subcellular Location:
Nucleus
Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;INTERACTION WITH RAD1
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;VARIANT ARG-557
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 2);TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;FUNCTION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4);INDUCTION;TISSUE SPECIFICITY
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
NIEHS SNPs program
Submitted (2004-04) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS ILE-32; LEU-487; GLU-535 AND ARG-557
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ARG-557
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Cited for: INTERACTION WITH THE RAD1/RAD9/HUS1 COMPLEX AND RFC3;MUTAGENESIS OF LYS-143
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Cited for: FUNCTION;INTERACTION WITH ATM; ATR AND RAD1;PHOSPHORYLATION AT SER-646 AND SER-656;MUTAGENESIS OF SER-646 AND SER-656
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Cited for: IDENTIFICATION IN A COMPLEX WITH RFC2; RFC3; RFC4 AND RFC5
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Cited for: FUNCTION;PHOSPHORYLATION AT SER-646 AND SER-656;INTERACTION WITH RFC4;MUTAGENESIS OF SER-191; SER-646 AND SER-656
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Cited for: FUNCTION;PHOSPHORYLATION;MUTAGENESIS OF LYS-143;SUBCELLULAR LOCATION
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Cited for: FUNCTION;PHOSPHORYLATION AT SER-646 AND SER-656;MUTAGENESIS OF SER-646 AND SER-656;INTERACTION WITH POLE
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Cited for: FUNCTION;INTERACTION WITH RFC2; RFC3; RFC4 AND RFC5;IDENTIFICATION BY MASS SPECTROMETRY
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Cited for: INTERACTION WITH PPP5C;PHOSPHORYLATION AT SER-646
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Cited for: FUNCTION;MUTAGENESIS OF LYS-143; SER-646 AND SER-656
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
