Rala ELISA Kit for Rat(Rattus norvegicus) | EIAab.comRala ELISA Kit for Rat(Rattus norvegicus)

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Rala (Gene name),

Ras-related protein Ral-A (Protein name ), RALA_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rala(Ral;Ral-a);

Protein name:

Ras-related protein Ral-A;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding (By similarity). Interacts with RALGPS1 (By similarity). Interacts with RALBP1 via its effector domain and with CDC42. Interacts with LPAR1 and LPAR2. Interacts with ADRBK1 in response to LPAR1 activation. RALA and ADRBK1 mutually inhibit each other's binding to LPAR1.

Function:

Multifuntional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Plays a role in the early stages of cytokinesis and is required to tether the exocyst to the cytokinetic furrow. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling. Key regulator of LPAR1 signaling and competes with ADRBK1 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells.

Subcellular Location:

Cell surface Cell membrane Lipid-anchor Cytoplasmic side Cleavage furrow Midbody Prior to LPA treatment found predominantly at the cell surface and in the presence of LPA co-localizes with LPAR1 and LPAR2 in the endocytic vesicles. During early cytokinesis localizes at the cleavage furrow membrane. Colocalizes with EXOC2 at the early midbody ring and persists there till maturation of the midbody.

Protein Attributes:

Sequence length:

206

Sequence:

50:

100:

150:

200:

206:

ERCCIL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P63322

Pfam:

PF00071

SMR:

P63322

UniGene:

Rn.100380

KEGG:

rno:81757

Uniprot:

P63322

FOR

ELISA Kit for Rat Ras-related protein Ral-A

CLIA Kit for Rat Ras-related protein Ral-A

Polyclonal Antibody for Rat Ras-related protein Ral-A

Monoclonal Antibody for Rat Ras-related protein Ral-A

Protein for Rat Ras-related protein Ral-A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Isolation of cDNA clones and tissue expression of rat ral A and ral B GTP-binding proteins."
Wildey G.M. , Viggeswarapu M. , Rim S. , Denker J.K.
Biochem. Biophys. Res. Commun.194:552-559(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
2.

"Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases."
Cantor S.B. , Urano T. , Feig L.A.
Mol. Cell. Biol.15:4578-4584(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RALBP1 AND CDC42;MUTAGENESIS OF ASP-49

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