Ran-binding protein 9 (Protein name
), RANB9_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
RANBP9(RANBPM);
Protein name:
Ran-binding protein 9(RanBP9);
Alternative:
BPM90;BPM-L;RanBP7;Ran-binding protein M(RanBPM);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, C20orf11, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and C20ORF11. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. Directly interacts with RANBP10.
Function:
May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.
Subcellular Location:
Cytoplasm
cytosol
Nucleus
=Predominantly cytoplasmic. A phosphorylated form is associated with the plasma membrane.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 85-729 (ISOFORM 1);INTERACTION WITH RAN
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 136-729 (ISOFORM 1);INTERACTION WITH HIPK2;SUBCELLULAR LOCATION
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 148-729 (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INTERACTION WITH AR
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Cited for: FUNCTION IN RAS SIGNALING;INTERACTION WITH MET AND SOS;TISSUE SPECIFICITY
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Cited for: INTERACTION WITH CDC2L1;PHOSPHORYLATION;SUBCELLULAR LOCATION
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Cited for: INTERACTION WITH MKLN1 AND GID8;IDENTIFICATION IN A COMPLEX WITH MKLN1 AND GID8
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Cited for: FUNCTION;INTERACTION WITH DYRK1A AND DYRK1B;IDENTIFICATION IN A COMPLEX WITH RAN; DYRK1B AND COPS5
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Cited for: FUNCTION;INTERACTION WITH ITGB1 AND ITGB2;SUBCELLULAR LOCATION;PHOSPHORYLATION
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Cited for: FUNCTION;INTERACTION WITH FMR1;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
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Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TP73
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;INTERACTION WITH RANBP10;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-487;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-405;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
Vaild Sequence:
