HRAS ELISA Kit for Human(Homo sapiens) | EIAab.comHRAS ELISA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > HRAS(Gene name) > Human

HRAS (Gene name),

GTPase HRas (Protein name ), RASH_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

HRAS(HRAS1);

Protein name:

GTPase HRas;

Alternative:

Ha-Ras;H-Ras-1;c-H-ras;Transforming protein p21;p21ras;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

In its GTP-bound form interacts with PLCE1. Interacts with TBC1D10C. Interacts with RGL3. Interacts with HSPD1. Found in a complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14. Interacts (active GTP-bound form) with RGS14 (via RBD 1 domain) (By similarity). Forms a signaling complex with RASGRP1 and DGKZ. Interacts with RASSF5. Interacts with PDE6D. Interacts with IKZF3. Interacts with GNB2L1.

Function:

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

Subcellular Location:

Isoform 2 Nucleus Cytoplasm Cytoplasm perinuclear region Colocalizes with GNB2L1 to the perinuclear region.

Protein Attributes:

Sequence length:

189

Sequence:

50:

100:

150:

189:

GVEDAFYTLV | REIRQHKLRK | LNPPDESGPG | CMSCKCVLS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

Pfam:

PF00071

STRING:

9606.ENSP00000309845

UniGene:

Hs.37003

SMR:

P01112

KEGG:

hsa:3265

MIM:

109800

String:

P01112

Uniprot:

P01112

FOR

ELISA Kit for Human GTPase HRas

Cat.:

E1294h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human GTPase HRas

Cat.:

U1294h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human GTPase HRas

Cat.:

P1294Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human GTPase HRas

Protein for Human GTPase HRas

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue."
Capon D.J. , Chen E.Y. , Levinson A.D. , Seeburg P.H. , Goeddel D.V.
Nature302:33-37(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene."
Reddy E.P.
Science220:1061-1063(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient."
Sekiya T. , Fushimi M. , Hori H. , Hirohashi S. , Nishimura S. , Sugimura T.
Proc. Natl. Acad. Sci. U.S.A.81:4771-4775(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus."
Guil S. , de La Iglesia N. , Fernandez-Larrea J. , Cifuentes D. , Ferrer J.C. , Guinovart J.J. , Bach-Elias M.
Cancer Res.63:5178-5187(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH GNB2L1;SUBCELLULAR LOCATION;ALTERNATIVE SPLICING;TISSUE SPECIFICITY;MUTAGENESIS OF SER-17
5.

"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III , Ikeda S.R. , Aronstam R.S.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
6.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
7.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.

NIEHS SNPs program
Submitted (2006-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
9.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
10.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Lung carcinoma.
12.

Bienvenut W.V. , Calvo F. , Kolch W.
Submitted (2008-02) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1-41; 43-117; 129-161 AND 170-185;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT MET-1 AND THR-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Cervix carcinoma.
13.

"Mechanism of activation of a human oncogene."
Tabin C.J. , Bradley S.M. , Bargmann C.I. , Weinberg R.A. , Papageorge A.G. , Scolnick E.M. , Dhar R. , Lowy D.R. , Chang E.H.
Nature300:143-149(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37
14.

"Identification of the principal promoter sequence of the c-H-ras transforming oncogene: deletion analysis of the 5'-flanking region by focus formation assay."
Honkawa H. , Masahashi W. , Hashimoto S. , Hashimoto-Gotoh T.
Mol. Cell. Biol.7:2933-2940(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-16
15.

"Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP."
Loew A. , Sprinzl M. , Faulhammer H.G.
Eur. J. Biochem.215:473-479(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 108-117 AND 132-153
16.

"Isolation of ras GTP-binding mutants using an in situ colony-binding assay."
Feig L.A. , Pan B.-T. , Roberts T.M. , Cooper G.M.
Proc. Natl. Acad. Sci. U.S.A.83:4607-4611(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ALA-83; ASP-119 AND THR-144
17.

"Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities."
Lacal J.C. , Anderson P.S. , Aaronson S.A.
EMBO J.5:679-687(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF 164-ARG-GLN-165
18.

"All ras proteins are polyisoprenylated but only some are palmitoylated."
Hancock J.F. , Magee A.I. , Childs J.E. , Marshall C.J.
Cell57:1167-1177(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-181 AND CYS-184
19.

"Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes."
Dudler T. , Gelb M.H.
J. Biol. Chem.271:11541-11547(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-181 AND CYS-184;ISOPRENYLATION AT CYS-186;METHYLATION AT CYS-186;MUTAGENESIS OF CYS-181 AND CYS-184
20.

"A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction."
Lander H.M. , Hajjar D.P. , Hempstead B.L. , Mirza U.A. , Chait B.T. , Campbell S. , Quilliam L.A.
J. Biol. Chem.272:4323-4326(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: S-NITROSYLATION AT CYS-118;FUNCTION;MASS SPECTROMETRY;MUTAGENESIS OF CYS-118
21.

"Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization."
Romero F. , Martinez-A C. , Camonis J. , Rebollo A.
EMBO J.18:3419-3430(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IKZF3
22.

"RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans."
Liao Y. , Kariya K. , Hu C.-D. , Shibatohge M. , Goshima M. , Okada T. , Watari Y. , Gao X. , Jin T.-G. , Yamawaki-Kataoka Y. , Kataoka T.
J. Biol. Chem.274:37815-37820(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAPGEF2
23.

"Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras."
Song C. , Hu C.-D. , Masago M. , Kariya K. , Yamawaki-Kataoka Y. , Shibatohge M. , Wu D. , Satoh T. , Kataoka T.
J. Biol. Chem.276:2752-2757(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PLCE1;CHARACTERIZATION OF VARIANT VAL-12;MUTAGENESIS OF SER-17; ASN-26; VAL-29; TYR-32; PRO-34; THR-35; GLU-37; ASP-38 AND SER-39
24.

"Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF."
Pham N. , Rotin D.
J. Biol. Chem.276:46995-47003(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAPGEF2
25.

"Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism."
Topham M.K. , Prescott S.M.
J. Cell Biol.152:1135-1143(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH RASGRP1 AND DGKZ
26.

"The complex of Arl2-GTP and PDE delta: from structure to function."
Hanzal-Bayer M. , Renault L. , Roversi P. , Wittinghofer A. , Hillig R.C.
EMBO J.21:2095-2106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDE6D
27.

"The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras."
Oliva J.L. , Perez-Sala D. , Castrillo A. , Martinez N. , Canada F.J. , Bosca L. , Rojas J.M.
Proc. Natl. Acad. Sci. U.S.A.100:4772-4777(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIPIDATION AT CYS-184;MUTAGENESIS OF CYS-184
28.

"Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease."
Liu F. , Iqbal K. , Grundke-Iqbal I. , Rossie S. , Gong C.X.
J. Biol. Chem.280:1790-1796(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF CSTLO VARIANT VAL-12
29.

"DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras."
Swarthout J.T. , Lobo S. , Farh L. , Croke M.R. , Greentree W.K. , Deschenes R.J. , Linder M.E.
J. Biol. Chem.280:31141-31148(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-181 AND CYS-184
30.

"An acylation cycle regulates localization and activity of palmitoylated Ras isoforms."
Rocks O. , Peyker A. , Kahms M. , Verveer P.J. , Koerner C. , Lumbierres M. , Kuhlmann J. , Waldmann H. , Wittinghofer A. , Bastiaens P.I.H.
Science307:1746-1752(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-181 AND CYS-184;MUTAGENESIS OF CYS-181 AND CYS-184;SUBCELLULAR LOCATION
31.

"Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin."
Pan F. , Sun L. , Kardian D.B. , Whartenby K.A. , Pardoll D.M. , Liu J.O.
Nature445:433-436(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D10C
32.

"Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21."
de Vos A.M. , Tong L. , Milburn M.V. , Matias P.M. , Jancarik J. , Noguchi S. , Nishimura S. , Miura K. , Ohtsuka E. , Kim S.-H.
Science239:888-893(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
33.

"Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation."
Pai E.F. , Kabsch W. , Krengel U. , Holmes K.C. , John J. , Wittinghofer A.
Nature341:209-214(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
34.

"Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35-A resolution: implications for the mechanism of GTP hydrolysis."
Pai E.F. , Krengel U. , Petsko G.A. , Goody R.S. , Kabsch W. , Wittinghofer A.
EMBO J.9:2351-2359(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS)
35.

"Crystal structures at 2.2-A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP."
Tong L.A. , de Vos A.M. , Milburn M.V. , Kim S.H.
J. Mol. Biol.217:503-516(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
36.

"Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy."
Kraulis P.J. , Domaille P.J. , Campbell-Burk S.L. , van Aken T. , Laue E.D.
Biochemistry33:3515-3531(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-166
37.

"The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants."
Scheffzek K. , Ahmadian M.R. , Kabsch W. , Wiesmuller L. , Lautwein A. , Schmitz F. , Wittinghofer A.
Science277:333-338(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1-166 IN COMPLEX WITH RASGAP
38.

"The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins."
Scheidig A.J. , Burmester C. , Goody R.S.
Structure7:1311-1324(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS)
39.

"The structural basis for the transition from Ras-GTP to Ras-GDP."
Hall B.E. , Bar-Sagi D. , Nassar N.
Proc. Natl. Acad. Sci. U.S.A.99:12138-12142(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 1-166 IN COMPLEXES WITH GTP ANALOGS
40.

"Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange."
Williams J.G. , Pappu K. , Campbell S.L.
Proc. Natl. Acad. Sci. U.S.A.100:6376-6381(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-166;S-NITROSYLATION;FUNCTION;MUTAGENESIS OF CYS-118;IDENTIFICATION BY MASS SPECTROMETRY
41.

"Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf."
Buhrman G. , Wink G. , Mattos C.
Structure15:1618-1629(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-166 IN COMPLEXES WITH GTP ANALOG;CHARACTERIZATION OF VARIANTS LEU-61 AND LYS-61;MUTAGENESIS OF GLN-61
42.

"Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II."
Stieglitz B. , Bee C. , Schwarz D. , Yildiz O. , Moshnikova A. , Khokhlatchev A. , Herrmann C.
EMBO J.27:1995-2005(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1-166 IN COMPLEX WITH RASSF5
43.

"The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma."
Sakai E. , Rikimaru K. , Ueda M. , Matsumoto Y. , Ishii N. , Enomoto S. , Yamamoto H. , Tsuchida N.
Int. J. Cancer52:867-872(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-12
44.

"RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma."
Nikiforova M.N. , Lynch R.A. , Biddinger P.W. , Alexander E.K. , Dorn G.W. II , Tallini G. , Kroll T.G. , Nikiforov Y.E.
J. Clin. Endocrinol. Metab.88:2318-2326(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LYS-61;INVOLVEMENT IN SUSCEPTIBILITY TO HURTHLE CELL THYROID CARCINOMA
45.

"Germline mutations in HRAS proto-oncogene cause Costello syndrome."
Aoki Y. , Niihori T. , Kawame H. , Kurosawa K. , Ohashi H. , Tanaka Y. , Filocamo M. , Kato K. , Suzuki Y. , Kure S. , Matsubara Y.
Nat. Genet.37:1038-1040(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO ALA-12; SER-12; VAL-12 AND ASP-13
46.

"HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation."
Gripp K.W. , Lin A.E. , Stabley D.L. , Nicholson L. , Scott C.I. Jr. , Doyle D. , Aoki Y. , Matsubara Y. , Zackai E.H. , Lapunzina P. , Gonzalez-Meneses A. , Holbrook J. , Agresta C.A. , Gonzalez I.L. , Sol-Church K.
Am. J. Med. Genet. A140:1-7(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO ALA-12; SER-12 AND CYS-13
47.

"Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases."
Kerr B. , Delrue M.-A. , Sigaudy S. , Perveen R. , Marche M. , Burgelin I. , Stef M. , Tang B. , Eden O.B. , O'Sullivan J. , De Sandre-Giovannoli A. , Reardon W. , Brewer C. , Bennett C. , Quarell O. , M'Cann E. , Donnai D. , Stewart F. , more...
J. Med. Genet.43:401-405(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO SER-12; CYS-12; GLU-12; ALA-12 AND ARG-117
48.

"Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome."
Zampino G. , Pantaleoni F. , Carta C. , Cobellis G. , Vasta I. , Neri C. , Pogna E.A. , De Feo E. , Delogu A. , Sarkozy A. , Atzeri F. , Selicorni A. , Rauen K.A. , Cytrynbaum C.S. , Weksberg R. , Dallapiccola B. , Ballabio A. , Gelb B.D. , more...
Hum. Mutat.28:265-272(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO SER-12 AND THR-146
49.

"Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation."
van der Burgt I. , Kupsky W. , Stassou S. , Nadroo A. , Barroso C. , Diem A. , Kratz C.P. , Dvorsky R. , Ahmadian M.R. , Zenker M.
J. Med. Genet.44:459-462(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CMEMS VAL-12; SER-12; LYS-22 AND LYS-63
50.

"Costello syndrome associated with novel germline HRAS mutations: an attenuated phenotype?"
Gripp K.W. , Innes A.M. , Axelrad M.E. , Gillan T.L. , Parboosingh J.S. , Davies C. , Leonard N.J. , Lapointe M. , Doyle D. , Catalano S. , Nicholson L. , Stabley D.L. , Sol-Church K.
Am. J. Med. Genet. A146:683-690(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO ILE-58 AND VAL-146
51.

"Severe neonatal manifestations of Costello syndrome."
Lo I.F. , Brewer C. , Shannon N. , Shorto J. , Tang B. , Black G. , Soo M.T. , Ng D.K. , Lam S.T. , Kerr B.
J. Med. Genet.45:167-171(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CSTLO ASP-12 AND CYS-12
52.

"Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation."
Gremer L. , De Luca A. , Merbitz-Zahradnik T. , Dallapiccola B. , Morlot S. , Tartaglia M. , Kutsche K. , Ahmadian M.R. , Rosenberger G.
Hum. Mol. Genet.19:790-802(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CSTLO GLU-37 INS
53.

"Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome."
Groesser L. , Herschberger E. , Ruetten A. , Ruivenkamp C. , Lopriore E. , Zutt M. , Langmann T. , Singer S. , Klingseisen L. , Schneider-Brachert W. , Toll A. , Real F.X. , Landthaler M. , Hafner C.
Nat. Genet.44:783-787(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SFM ARG-13;CHARACTERIZATION OF VARIANT SFM ARG-13

Product Feedback Wall

* Email:
*Comments: