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Index > Protein center > RBBP7(Gene name) > Human
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  • RBBP7 (Gene name),
  • Histone-binding protein RBBP7 (Protein name ),  RBBP7_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    RBBP7(RBAP46);
    Protein name:
    Histone-binding protein RBBP7;
    Alternative:
    Nucleosome-remodeling factor subunit RBAP46;Histone acetyltransferase type B subunit 2;Retinoblastoma-binding protein p46;Retinoblastoma-binding protein 7(RBBP-7);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1.
    Function:
    Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    425
    Sequence:
    50:
    MASKEMFEDT | VEERVINEEY | KIWKKNTPFL | YDLVMTHALQ | WPSLTVQWLP | 
    100:
    EVTKPEGKDY | ALHWLVLGTH | TSDEQNHLVV | ARVHIPNDDA | QFDASHCDSD | 
    150:
    KGEFGGFGSV | TGKIECEIKI | NHEGEVNRAR | YMPQNPHIIA | TKTPSSDVLV | 
    200:
    FDYTKHPAKP | DPSGECNPDL | RLRGHQKEGY | GLSWNSNLSG | HLLSASDDHT | 
    250:
    VCLWDINAGP | KEGKIVDAKA | IFTGHSAVVE | DVAWHLLHES | LFGSVADDQK | 
    300:
    LMIWDTRSNT | TSKPSHLVDA | HTAEVNCLSF | NPYSEFILAT | GSADKTVALW | 
    350:
    DLRNLKLKLH | TFESHKDEIF | QVHWSPHNET | ILASSGTDRR | LNVWDLSKIG | 
    400:
    EEQSAEDAED | GPPELLFIHG | GHTAKISDFS | WNPNEPWVIC | SVSEDNIMQI | 
    425:
    WQMAENIYND | EESDVTTSEL | EGQGS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    String:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Histone-binding protein RBBP7
    ELISA Kit for Human Histone-binding protein RBBP7
    ELISA Kit for Human Histone-binding protein RBBP7
    ELISA Kit for Human Histone-binding protein RBBP7
    ELISA Kit for Human Histone-binding protein RBBP7
    CLIA Kit for Human Histone-binding protein RBBP7
    CLIA Kit for Human Histone-binding protein RBBP7
    CLIA Kit for Human Histone-binding protein RBBP7
    CLIA Kit for Human Histone-binding protein RBBP7
    CLIA Kit for Human Histone-binding protein RBBP7
    Polyclonal Antibody for Human Histone-binding protein RBBP7
    Polyclonal Antibody for Human Histone-binding protein RBBP7
    Polyclonal Antibody for Human Histone-binding protein RBBP7
    Polyclonal Antibody for Human Histone-binding protein RBBP7
    Polyclonal Antibody for Human Histone-binding protein RBBP7
    Monoclonal Antibody for Human Histone-binding protein RBBP7
    Monoclonal Antibody for Human Histone-binding protein RBBP7
    Monoclonal Antibody for Human Histone-binding protein RBBP7
    Monoclonal Antibody for Human Histone-binding protein RBBP7
    Monoclonal Antibody for Human Histone-binding protein RBBP7
    Protein for Human Histone-binding protein RBBP7
    Protein for Human Histone-binding protein RBBP7
    Protein for Human Histone-binding protein RBBP7
    Protein for Human Histone-binding protein RBBP7
    Protein for Human Histone-binding protein RBBP7

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH RB1
    2. 2.
      Nielsen M.S. , Rasmussen H.H. , Dejgaard K. , Celis J.E. , Leffers H.
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    3. 3.
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      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Kidney.
    4. 4.
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      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
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      Zhang Y. , Iratni R. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
      Cell89:357-364(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;IDENTIFICATION IN THE SIN3 HDAC COMPLEX
    6. 6.
      "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities."
      Zhang Y. , LeRoy G. , Seelig H.-P. , Lane W.S. , Reinberg D.
      Cell95:279-289(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX
    7. 7.
      "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase."
      Verreault A. , Kaufman P.D. , Kobayashi R. , Stillman B.
      Curr. Biol.8:96-108(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HAT1 AND HISTONE H4
    8. 8.
      "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex."
      Zhang Y. , Sun Z.-W. , Iratni R. , Erdjument-Bromage H. , Tempst P. , Hampsey M. , Reinberg D.
      Mol. Cell1:1021-1031(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX
    9. 9.
      "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation."
      Zhang Y. , Ng H.-H. , Erdjument-Bromage H. , Tempst P. , Bird A. , Reinberg D.
      Genes Dev.13:1924-1935(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX
    10. 10.
      "BRCA1 interacts with components of the histone deacetylase complex."
      Yarden R.I. , Brody L.C.
      Proc. Natl. Acad. Sci. U.S.A.96:4983-4988(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRCA1 AND RB1
    11. 11.
      "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB."
      Zhang Q. , Vo N. , Goodman R.H.
      Mol. Cell. Biol.20:4970-4978(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CREBBP
    12. 12.
      "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1."
      Humphrey G.W. , Wang Y. , Russanova V.R. , Hirai T. , Qin J. , Nakatani Y. , Howard B.H.
      J. Biol. Chem.276:6817-6824(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURD COMPLEX
    13. 13.
      "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex."
      Skowyra D. , Zeremski M. , Neznanov N. , Li M. , Choi Y. , Uesugi M. , Hauser C.A. , Gu W. , Gudkov A.V. , Qin J.
      J. Biol. Chem.276:8734-8739(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX
    14. 14.
      "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein."
      Kuzmichev A. , Nishioka K. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
      Genes Dev.16:2893-2905(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE PRC2/EED-EZH2 COMPLEX WITH EED; EZH2; RBBP4 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE COMPLEX
    15. 15.
      "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)."
      Kuzmichev A. , Zhang Y. , Erdjument-Bromage H. , Tempst P. , Reinberg D.
      Mol. Cell. Biol.22:835-848(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE SIN3 HDAC COMPLEX
    16. 16.
      "Isolation of human NURF: a regulator of Engrailed gene expression."
      Barak O. , Lazzaro M.A. , Lane W.S. , Speicher D.W. , Picketts D.J. , Shiekhattar R.
      EMBO J.22:6089-6100(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE NURF COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
    17. 17.
      "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity."
      Yao Y.-L. , Yang W.-M.
      J. Biol. Chem.278:42560-42568(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE MTA1 HDAC COMPLEX
    18. 18.
      "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex."
      Jiang C.-L. , Jin S.-G. , Pfeifer G.P.
      J. Biol. Chem.279:52456-52464(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MBD3L1
    19. 19.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    21. 21.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    22. 22.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    25. 25.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    26. 26.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    27. 27.
      "Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46."
      Murzina N.V. , Pei X.Y. , Zhang W. , Sparkes M. , Vicente-Garcia J. , Pratap J.V. , McLaughlin S.H. , Ben-Shahar T.R. , Verreault A. , Luisi B.F. , Laue E.D.
      Structure16:1077-1085(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 2-411 IN COMPLEX WITH HISTONE H4;DOMAINS WD REPEATS
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