Gene name:
RBBP7 (RBAP46) ;
Protein name:
Histone-binding protein RBBP7 ;
Alternative:
Nucleosome-remodeling factor subunit RBAP46 ;Histone acetyltransferase type B subunit 2 ;Retinoblastoma-binding protein p46 ;Retinoblastoma-binding protein 7 (RBBP-7) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin. Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex. The core HDAC complex may also associate with MTA2, MBD3, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylase complex (the NuRD complex). The NuRD complex may also interact with MBD3L1 and MBD3L2. Interacts with MTA1. Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12. The PRC2/EED-EZH2 complex may also associate with HDAC1. Part of the nucleosome remodeling factor (NURF) complex which consists of SMARCA1; BPTF; RBBP4 and RBBP7. Interacts with the viral protein-binding domain of the retinoblastoma protein (RB1). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP. Interacts with BRCA1, HDAC7 and SUV39H1.
Function:
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MASKEMFEDT | VEERVINEEY | KIWKKNTPFL | YDLVMTHALQ | WPSLTVQWLP |
100:
EVTKPEGKDY | ALHWLVLGTH | TSDEQNHLVV | ARVHIPNDDA | QFDASHCDSD |
150:
KGEFGGFGSV | TGKIECEIKI | NHEGEVNRAR | YMPQNPHIIA | TKTPSSDVLV |
200:
FDYTKHPAKP | DPSGECNPDL | RLRGHQKEGY | GLSWNSNLSG | HLLSASDDHT |
250:
VCLWDINAGP | KEGKIVDAKA | IFTGHSAVVE | DVAWHLLHES | LFGSVADDQK |
300:
LMIWDTRSNT | TSKPSHLVDA | HTAEVNCLSF | NPYSEFILAT | GSADKTVALW |
350:
DLRNLKLKLH | TFESHKDEIF | QVHWSPHNET | ILASSGTDRR | LNVWDLSKIG |
400:
EEQSAEDAED | GPPELLFIHG | GHTAKISDFS | WNPNEPWVIC | SVSEDNIMQI |
425:
WQMAENIYND | EESDVTTSEL | EGQGS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Rat
Chicken
Human
ELISA Kit for Human Histone-binding protein RBBP7
ELISA Kit for Human Histone-binding protein RBBP7
ELISA Kit for Human Histone-binding protein RBBP7
ELISA Kit for Human Histone-binding protein RBBP7
ELISA Kit for Human Histone-binding protein RBBP7
CLIA Kit for Human Histone-binding protein RBBP7
CLIA Kit for Human Histone-binding protein RBBP7
CLIA Kit for Human Histone-binding protein RBBP7
CLIA Kit for Human Histone-binding protein RBBP7
CLIA Kit for Human Histone-binding protein RBBP7
Polyclonal Antibody for Human Histone-binding protein RBBP7
Polyclonal Antibody for Human Histone-binding protein RBBP7
Polyclonal Antibody for Human Histone-binding protein RBBP7
Polyclonal Antibody for Human Histone-binding protein RBBP7
Polyclonal Antibody for Human Histone-binding protein RBBP7
Monoclonal Antibody for Human Histone-binding protein RBBP7
Monoclonal Antibody for Human Histone-binding protein RBBP7
Monoclonal Antibody for Human Histone-binding protein RBBP7
Monoclonal Antibody for Human Histone-binding protein RBBP7
Monoclonal Antibody for Human Histone-binding protein RBBP7
Protein for Human Histone-binding protein RBBP7
Protein for Human Histone-binding protein RBBP7
Protein for Human Histone-binding protein RBBP7
Protein for Human Histone-binding protein RBBP7
Protein for Human Histone-binding protein RBBP7
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH RB1
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
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"The DNA sequence of the human X chromosome."
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;IDENTIFICATION IN THE SIN3 HDAC COMPLEX
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE NURD COMPLEX
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HAT1 AND HISTONE H4
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE SIN3 HDAC COMPLEX
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE NURD COMPLEX
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BRCA1 AND RB1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CREBBP
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE NURD COMPLEX
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE SIN3 HDAC COMPLEX
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE PRC2/EED-EZH2 COMPLEX WITH EED; EZH2; RBBP4 AND SUZ12;METHYLTRANSFERASE ACTIVITY OF THE COMPLEX
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE SIN3 HDAC COMPLEX
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE NURF COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE MTA1 HDAC COMPLEX
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MBD3L1
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-4;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 (ISOFORM 2);PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-354;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
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Hole K.
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Larrea E.
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Timmerman E.
,
Prieto J.
,
Arnesen T.
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Sherman F.
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Gevaert K.
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Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.
"Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46."
Murzina N.V.
,
Pei X.Y.
,
Zhang W.
,
Sparkes M.
,
Vicente-Garcia J.
,
Pratap J.V.
,
McLaughlin S.H.
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Ben-Shahar T.R.
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Verreault A.
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Luisi B.F.
,
Laue E.D.
Structure16:1077-1085(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 2-411 IN COMPLEX WITH HISTONE H4;DOMAINS WD REPEATS