Protein name:
    Reversion-inducing cysteine-rich protein with Kazal motifs (hRECK) ;
    
    Alternative:
    
    Suppressor of tumorigenicity 15 protein ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Interacts with MMP-9.
    
 
    Function:
    Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Cell membrane  
      Lipid-anchor  
      GPI-anchor 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MATVRASLRG |  ALLLLLAVAG |  VAEVAGGLAP |  GSAGALCCNH |  SKDNQMCRDV |  
    
 
    100:
    CEQIFSSKSE |  SRLKHLLQRA |  PDYCPETMVE |  IWNCMNSSLP |  GVFKKSDGWV |  
    
 
    150:
    GLGCCELAIA |  LECRQACKQA |  SSKNDISKVC |  RKEYENALFS |  CISRNEMGSV |  
    
 
    200:
    CCSYAGHHTN |  CREYCQAIFR |  TDSSPGPSQI |  KAVENYCASI |  SPQLIHCVNN |  
    
 
    250:
    YTQSYPMRNP |  TDSLYCCDRA |  EDHACQNACK |  RILMSKKTEM |  EIVDGLIEGC |  
    
 
    300:
    KTQPLPQDPL |  WQCFLESSQS |  VHPGVTVHPP |  PSTGLDGAKL |  HCCSKANTST |  
    
 
    350:
    CRELCTKLYS |  MSWGNTQSWQ |  EFDRFCEYNP |  VEVSMLTCLA |  DVREPCQLGC |  
    
 
    400:
    RNLTYCTNFN |  NRPTELFRSC |  NAQSDQGAMN |  DMKLWEKGSI |  KMPFINIPVL |  
    
 
    450:
    DIKKCQPEMW |  KAIACSLQIK |  PCHSKSRGSI |  ICKSDCVEIL |  KKCGDQNKFP |  
    
 
    500:
    EDHTAESICE |  LLSPTDDLKN |  CIPLDTYLRP |  STLGNIVEEV |  THPCNPNPCP |  
    
 
    550:
    ANELCEVNRK |  GCPSGDPCLP |  YFCVQGCKLG |  EASDFIVRQG |  TLIQVPSSAG |  
    
 
    600:
    EVGCYKICSC |  GQSGLLENCM |  EMHCIDLQKS |  CIVGGKRKSH |  GTSFSIDCNV |  
    
 
    650:
    CSCFAGNLVC |  STRLCLSEHS |  SEDDRRTFTG |  LPCNCADQFV |  PVCGQNGRTY |  
    
 
    700:
    PSACIARCVG |  LQDHQFEFGS |  CMSKDPCNPN |  PCQKNQRCIP |  KPQVCLTTFD |  
    
 
    750:
    KFGCSQYECV |  PRQLACDQVQ |  DPVCDTDHME |  HNNLCTLYQR |  GKSLSYKGPC |  
    
 
    800:
    QPFCRATEPV |  CGHNGETYSS |  VCAAYSDRVA |  VDYYGDCQAV |  GVLSEHSSVA |  
    
 
    850:
    ECASVKCPSL |  LAAGCKPIIP |  PGACCPLCAG |  MLRVLFDKEK |  LDTIAKVTNK |  
    
 
    900:
    KPITVLEILQ |  KIRMHVSVPQ |  CDVFGYFSIE |  SEIVILIIPV |  DHYPKALQIE |  
    
 
    950:
    ACNKEAEKIE |  SLINSDSPTL |  ASHVPLSALI |  ISQVQVSSSV |  PSAGVRARPS |  
    
 
    971:
    CHSLLLPLSL |  GLALHLLWTY |  N
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
     
    
        ELISA Kit for Human hRECK
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human hRECK
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human hRECK
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human hRECK
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human hRECK
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human hRECK
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Precision
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Recovery
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Linearity
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    
    
    References
    
    
        
            
        
            
                1.
                
                    
                        
                            "Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK." 
                        
                        
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Sheng Z. 
                        ,
                            
Horan T.P. 
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION 
                    
                    
                    tissue :
                    
Fibroblast .  
             
         
            
        
            
                2.
                
                    
                        
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                              more...   
                             
                        
                        
                        
                            Nature429:369-374(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                3.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
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                        ,
                            
Florea L. 
                        ,
                            
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                        ,
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                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                    tissue :
                    
Lung .