RECQL5 ELISA Kit for Human(Homo sapiens) | EIAab.comRECQL5 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > RECQL5(Gene name) > Human

RECQL5 (Gene name),

ATP-dependent DNA helicase Q5 (Protein name ), RECQ5_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

RECQL5(RECQ5);

Protein name:

ATP-dependent DNA helicase Q5;

Alternative:

RecQ protein-like 5;DNA helicase, RecQ-like type 5(RecQ5);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with TOP3A and TOP3B.

Function:

May have an important role in DNA metabolism.

Subcellular Location:

Isoform Gamma Cytoplasm

Protein Attributes:

Sequence length:

991

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

991:

QKTSPGRSVK | EEAQNLIRHF | FHGRARCESE | ADWHGLCGPQ | R

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:9400

MIM:

603781

Pfam:

PF00270

String:

O94762

STRING:

9606.ENSP00000317636

UniGene:

Hs.632229

SMR:

O94762

Uniprot:

O94762

FOR

ELISA Kit for Human ATP-dependent DNA helicase Q5

CLIA Kit for Human ATP-dependent DNA helicase Q5

Polyclonal Antibody for Human ATP-dependent DNA helicase Q5

Monoclonal Antibody for Human ATP-dependent DNA helicase Q5

Protein for Human ATP-dependent DNA helicase Q5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes."
Kitao S. , Ohsugi I. , Ichikawa K. , Goto M. , Furuichi Y. , Shimamoto A.
Genomics54:443-452(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA)
tissue: Testis.
2.

"Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing."
Sekelsky J.J. , Brodsky M.H. , Rubin G.M. , Hawley R.S.
Nucleic Acids Res.27:3762-3769(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND GAMMA)
3.

"Human RecQ5-beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3-alpha and 3-beta."
Shimamoto A. , Nishikawa K. , Kitao S. , Furuichi Y.
Nucleic Acids Res.28:1647-1655(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; BETA AND GAMMA);SUBCELLULAR LOCATION;INTERACTION WITH TOP3A AND TOP3B
tissue: Testis.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM GAMMA)
tissue: Duodenum.
5.

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S. , Weil B. , Wellenreuther R. , Gassenhuber J. , Glassl S. , Ansorge W. , Boecher M. , Bloecker H. , Bauersachs S. , Blum H. , Lauber J. , Duesterhoeft A. , Beyer A. , Koehrer K. , Strack N. , Mewes H.-W. , Ottenwaelder B. , Obermaier B. , more...
Genome Res.11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 831-991
tissue: Testis.
6.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-815;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
7.

"Human RECQL5 overcomes thymidine-induced replication stress."
Blundred R. , Myers K. , Helleday T. , Goldman A.S. , Bryant H.E.
DNA Repair9:964-975(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
8.

"Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity."
Schwendener S. , Raynard S. , Paliwal S. , Cheng A. , Kanagaraj R. , Shevelev I. , Stark J.M. , Sung P. , Janscak P.
J. Biol. Chem.285:15739-15745(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD51;MUTAGENESIS OF PHE-666;FUNCTION
9.

"RecQL5 promotes genome stabilization through two parallel mechanisms--interacting with RNA polymerase II and acting as a helicase."
Islam M.N. , Fox D. III , Guo R. , Enomoto T. , Wang W.
Mol. Cell. Biol.30:2460-2472(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH RNA POLYMERASE II;INTERACTION WITH POLR2A AND RAD51;MUTAGENESIS OF ARG-550; GLU-584; TYR-597 AND LEU-602;IDENTIFICATION BY MASS SPECTROMETRY
10.

"Human RECQL5 participates in the removal of endogenous DNA damage."
Tadokoro T. , Ramamoorthy M. , Popuri V. , May A. , Tian J. , Sykora P. , Rybanska I. , Wilson D.M. III , Croteau D.L. , Bohr V.A.
Mol. Biol. Cell23:4273-4285(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
11.

"RECQL5 cooperates with Topoisomerase II alpha in DNA decatenation and cell cycle progression."
Ramamoorthy M. , Tadokoro T. , Rybanska I. , Ghosh A.K. , Wersto R. , May A. , Kulikowicz T. , Sykora P. , Croteau D.L. , Bohr V.A.
Nucleic Acids Res.40:1621-1635(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;INTERACTION WITH TOP2A
12.

"The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair."
Ramamoorthy M. , May A. , Tadokoro T. , Popuri V. , Seidman M.M. , Croteau D.L. , Bohr V.A.
Carcinogenesis34:2218-2230(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
13.

"Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5."
Kassube S.A. , Jinek M. , Fang J. , Tsutakawa S. , Nogales E.
Nat. Struct. Mol. Biol.20:892-899(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 515-620;STRUCTURE BY ELECTRON MICROSCOPY IN COMPLEX WITH RNA POLYMERASE II AND DNA;INTERACTION WITH POLR2A;SUBUNIT;FUNCTION;MUTAGENSIS OF ASP-157; TRP-504; TYR-508; ARG-515; LYS-515; HIS-552; LEU-556; LYS-598; LEU-602 AND LYS-603

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