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Index > Protein center > RFFL(Gene name) > Human
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  • RFFL (Gene name),
  • E3 ubiquitin-protein ligase rififylin (Protein name ),  RFFL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RFFL(RNF189;RNF34L);
    Protein name:
    E3 ubiquitin-protein ligase rififylin;
    Alternative:
    Caspases-8 and -10-associated RING finger protein 2(CARP-2);Caspase regulator CARP2;RING finger and FYVE-like domain-containing protein 1;FYVE-RING finger protein Sakura(Fring);RING finger protein 34-like;RING finger protein 189;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds CASP8 and CASP10.
    Function:
    Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    363
    Sequence:
    50:
    MWATCCNWFC | LDGQPEEVPP | PQGARMQAYS | NPGYSSFPSP | TGLEPSCKSC | 
    100:
    GAHFANTARK | QTCLDCKKNF | CMTCSSQVGN | GPRLCLLCQR | FRATAFQREE | 
    150:
    LMKMKVKDLR | DYLSLHDIST | EMCREKEELV | LLVLGQQPVI | SQEDRTRAST | 
    200:
    LSPDFPEQQA | FLTQPHSSMV | PPTSPNLPSS | SAQATSVPPA | QVQENQQANG | 
    250:
    HVSQDQEEPV | YLESVARVPA | EDETQSIDSE | DSFVPGRRAS | LSDLTDLEDI | 
    300:
    EGLTVRQLKE | ILARNFVNYK | GCCEKWELME | RVTRLYKDQK | GLQHLVSGAE | 
    350:
    DQNGGAVPSG | LEENLCKICM | DSPIDCVLLE | CGHMVTCTKC | GKRMNECPIC | 
    363:
    RQYVIRAVHV | FRS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase rififylin
    ELISA Kit for Human E3 ubiquitin-protein ligase rififylin
    ELISA Kit for Human E3 ubiquitin-protein ligase rififylin
    CLIA Kit for Human E3 ubiquitin-protein ligase rififylin
    CLIA Kit for Human E3 ubiquitin-protein ligase rififylin
    CLIA Kit for Human E3 ubiquitin-protein ligase rififylin
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase rififylin
    Protein for Human E3 ubiquitin-protein ligase rififylin
    Protein for Human E3 ubiquitin-protein ligase rififylin
    Protein for Human E3 ubiquitin-protein ligase rififylin

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Fring, a protein with a modified FYVE domain and a ring domain."
      Hong W.
      Submitted (2001-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      Kanbe D. , Araki K. , Nawa H.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis carcinoma.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Testis.
    7. 7.
      "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."
      McDonald E.R. III , El-Deiry W.S.
      Proc. Natl. Acad. Sci. U.S.A.101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;INTERACTION WITH CASP8 AND CASP10;MUTAGENESIS OF HIS-333;PROTEOLYTIC DEGRADATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PATHWAY
    8. 8.
      "CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation."
      Yang W. , Rozan L.M. , McDonald E.R. III , Navaraj A. , Liu J.J. , Matthew E.M. , Wang W. , Dicker D.T. , El-Deiry W.S.
      J. Biol. Chem.282:3273-3281(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN P53/TP53 UBIQUITINATION;INTERACTION WITH P53/TP53
    9. 9.
      "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."
      Yang W. , Dicker D.T. , Chen J. , El-Deiry W.S.
      Cell Cycle7:670-682(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF SFN;INTERACTION WITH MDM2 AND P53/TP53;INDUCTION
    10. 10.
      "CARP-2 is an endosome-associated ubiquitin ligase for RIP and regulates TNF-induced NF-kappaB activation."
      Liao W. , Xiao Q. , Tchikov V. , Fujita K. , Yang W. , Wincovitch S. , Garfield S. , Conze D. , El-Deiry W.S. , Schuetze S. , Srinivasula S.M.
      Curr. Biol.18:641-649(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TNF SIGNALING;INTERACTION WITH RIPK1;SUBCELLULAR LOCATION
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-229;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12."
      Gan X. , Wang J. , Wang C. , Sommer E. , Kozasa T. , Srinivasula S. , Alessi D. , Offermanns S. , Simon M.I. , Wu D.
      Nat. Cell Biol.14:686-696(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN UBIQUITINATION OF PRR5L;INTERACTION WITH PRR5L AND THE MTORC2 COMPLEX;DOMAIN
    13. 13.
      "Crystal structure of a FYVE-type zinc finger domain from the caspase regulator CARP2."
      Tibbetts M.D. , Shiozaki E.N. , Gu L. , McDonald E.R. III , El-Deiry W.S. , Shi Y.
      Structure12:2257-2263(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 26-145
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