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Index > Protein center > Rgs3(Gene name) > Mouse
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  • Rgs3 (Gene name),
  • Regulator of G-protein signaling 3 (Protein name ),  RGS3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Rgs3;
    Protein name:
    Regulator of G-protein signaling 3(RGS3);
    Alternative:
    C2PA;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Binds the GNB1-GNG2 heterodimer (By similarity). Binds EFNB1 and EFNB2.
    Function:
    Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases.
    Subcellular Location:
    Isoform 4 Nucleus Isoform 3 and probably also isoform 4 are nuclear.
    Protein Attributes:
    Sequence length:
    966
    Sequence:
    50:
    MNRFNGLCKV | CSERRYRQIT | IRRGKDGFGF | TICCDSPVRV | QAVDSGGPAE | 
    100:
    RAGLQQLDTV | LQLNERPVEH | WKCVELAHEI | RSCPSEIILL | VWRVVPQIKP | 
    150:
    GPDGGVLRRA | SCKSTHDLLS | PPNKREKNCT | HGAPVRPEQR | HSCHLVCDSS | 
    200:
    DGLLLGGWER | YTEVGKRSGQ | HTLPALSRTT | TPTDPNYIIL | APLNPGSQLL | 
    250:
    RPVYQEDTIP | EEPGTTTKGK | SYTGLGKKSR | LMKTVQTMKG | HSNYQDCSAL | 
    300:
    RPHIPHSSYG | TYVTLAPKVL | VFPVFVQPLD | LCNPARTLLL | SEELLLYEGR | 
    350:
    NKTSQVTLFA | YSDLLLFTKE | EEPGRCDVLR | NPLYLQSVKL | QEGSSEDLKF | 
    400:
    CVLYLAEKAE | CLFTLEAHSQ | EQKKRVCWCL | SENIAKQQQL | AAPPTERKMF | 
    450:
    ETEADEKEMP | LVEGKGPGAE | EPAPSKNPSP | GQELPPGQDL | PPSKDPSPSQ | 
    500:
    ELPAGQDLPP | SKDPSPSQEL | PAGQDLPPSK | DPSPSQELPV | GQDLPPRKDS | 
    550:
    SGQEAAPGPE | SPSSEDIATC | PKPPQSPETS | TSKDSPPGQG | SSPTTELPSC | 
    600:
    QGLPAGQEST | SQDPLLSQEP | PVIPESSASV | QKRLPSQESP | SSLGSLPEKD | 
    650:
    LAEQTISSGE | PPVATGAVLP | ASRPNFVIPE | VRLDNAYSQL | DGAHGGSSGE | 
    700:
    DEDAEEGEEG | GEGEEDEEDD | TSDDNYGDRS | EAKRSSLIET | GQGAEGGFSL | 
    750:
    RVQNSLRRRT | HSEGSLLQES | RGPCFASDTT | LHCSDGEGAT | STWAIPSPRT | 
    800:
    LKKELGRNGG | SMHHLSLFFT | GHRKMSGTDL | TECDEASRKR | KSKNIAKDMK | 
    850:
    NKLAIFRRRN | ESPGAQPASK | TDKTTKSFKP | TSEEALKWSE | SLEKLLLHKY | 
    900:
    GLEVFQAFLR | TEFSEENLEF | WLACEDFKKV | KSQSKMAAKA | KKIFAEFIAI | 
    950:
    QACKEVNLDS | YTREHTKENL | QSITRGCFDL | AQKRIFGLME | KDSYPRFLRS | 
    966:
    DLYLDLINQK | KMSPPL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse RGS3
    Cat.:
    E0251m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse RGS3
    Cat.:
    E0251h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse RGS3
    Cat.:
    E0251r
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse RGS3
    Cat.:
    U0251h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse RGS3
    Cat.:
    U0251r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse RGS3
    Cat.:
    U0251m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse RGS3
    Cat.:
    P0251Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse RGS3
    Cat.:
    P0251Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse RGS3
    Cat.:
    P0251Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse RGS3
    Monoclonal Antibody for Mouse RGS3
    Monoclonal Antibody for Mouse RGS3
    Protein for Mouse RGS3
    Protein for Mouse RGS3
    Protein for Mouse RGS3

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    References
    1. 1.
      "C2PA, a new protein expressed during mouse spermatogenesis."
      Linares J.-L. , Wendling C. , Tomasetto C. , Rio M.-C.
      FEBS Lett.480:249-254(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);TISSUE SPECIFICITY
      tissue: Testis.
    2. 2.
      "Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction."
      Lu Q. , Sun E.E. , Klein R.S. , Flanagan J.G.
      Cell105:69-79(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH EPHRINS;SUBCELLULAR LOCATION
      tissue: Embryo.
    3. 3.
      "EPP1, a novel PDZ protein expressed in the arterial endothelial cells binding to B ephrins."
      Huang W.-Y. , Izumo S.
      Submitted (2000-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 5)
      strain: C57BL/6J.
      tissue: Lung.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      strain: FVB/N.
      tissue: Mammary gland.
    7. 7.
      "RGS molecule expression in murine B lymphocytes and ability to down-regulate chemotaxis to lymphoid chemokines."
      Reif K. , Cyster J.G.
      J. Immunol.164:4720-4729(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORMS 5 AND 6)
      strain: C57BL/6J.
      tissue: Embryo.
    8. 8.
      "C2PA is a nuclear protein implicated in the heat shock response."
      Hirabayashi S. , Ohno H. , Iida J. , Hata Y.
      J. Cell. Biochem.87:65-74(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    9. 9.
      "Solution structure of the PDZ domain of RGS3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 10-94
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