Arhgap17 ELISA Kit for Mouse(Mus musculus) | EIAab.comArhgap17 ELISA Kit for Mouse(Mus musculus)

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Arhgap17 (Gene name),

Rho GTPase-activating protein 17 (Protein name ), RHG17_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Arhgap17;

Protein name:

Rho GTPase-activating protein 17;

Alternative:

Rho-type GTPase-activating protein 17;Neuron-associated developmentally-regulated protein(Nadrin);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with SLC9A3R1, FNBP1, TRIP10, CAPZA (CAPZA1, CAPZA2 or CAPZA3), CAPZB, CD2AP and SH3KBP1/CIN85.

Function:

Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activitor in vitro for RAC1.

Subcellular Location:

Membrane Peripheral membrane protein Cytoplasm Cell junction tight junction Associates with membranes and concentrates at sites of cell-cell contact.

Protein Attributes:

Sequence length:

846

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