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Index > Protein center > RNF111(Gene name) > Human
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  • RNF111 (Gene name),
  • E3 ubiquitin-protein ligase Arkadia (Protein name ),  RN111_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RNF111;
    Protein name:
    E3 ubiquitin-protein ligase Arkadia;
    Alternative:
    RING finger protein 111;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SMAD6, SMAD7, AXIN1, AXIN2 and SKIL isoform SNON. Part of a complex containing RNF111, AXIN1 and SMAD7.
    Function:
    Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
    Subcellular Location:
    Nucleus Cytoplasm Upon TGF-beta treatment, translocates from nucleus to cytosol.
    Protein Attributes:
    Sequence length:
    994
    Sequence:
    50:
    MSQWTPEYNE | LYTLKVDMKS | EIPSDAPKTQ | ESLKGILLHP | EPIGAAKSFP | 
    100:
    AGVEMINSKV | GNEFSHLCDD | SQKQEKEMNG | NQQEQEKSLV | VRKKRKSQQA | 
    150:
    GPSYVQNCVK | ENQGILGLRQ | HLGTPSDEDN | DSSFSDCLSS | PSSSLHFGDS | 
    200:
    DTVTSDEDKE | VSVRHSQTIL | NAKSRSHSAR | SHKWPRTETE | SVSGLLMKRP | 
    250:
    CLHGSSLRRL | PCRKRFVKNN | SSQRTQKQKE | RILMQRKKRE | VLARRKYALL | 
    300:
    PSSSSSSEND | LSSESSSSSS | TEGEEDLFVS | ASENHQNNPA | VPSGSIDEDV | 
    350:
    VVIEASSTPQ | VTANEEINVT | STDSEVEIVT | VGESYRSRST | LGHSRSHWSQ | 
    400:
    GSSSHASRPQ | EPRNRSRIST | VIQPLRQNAA | EVVDLTVDED | EPTVVPTTSA | 
    450:
    RMESQATSAS | INNSNPSTSE | QASDTASAVT | SSQPSTVSET | SATLTSNSTT | 
    500:
    GTSIGDDSRR | TTSSAVTETG | PPAMPRLPSC | CPQHSPCGGS | SQNHHALGHP | 
    550:
    HTSCFQQHGH | HFQHHHHHHH | TPHPAVPVSP | SFSDPACPVE | RPPQVQAPCG | 
    600:
    ANSSSGTSYH | EQQALPVDLS | NSGIRSHGSG | SFHGASAFDP | CCPVSSSRAA | 
    650:
    IFGHQAAAAA | PSQPLSSIDG | YGSSMVAQPQ | PQPPPQPSLS | SCRHYMPPPY | 
    700:
    ASLTRPLHHQ | ASACPHSHGN | PPPQTQPPPQ | VDYVIPHPVH | AFHSQISSHA | 
    750:
    TSHPVAPPPP | THLASTAAPI | PQHLPPTHQP | ISHHIPATAP | PAQRLHPHEV | 
    800:
    MQRMEVQRRR | MMQHPTRAHE | RPPPHPHRMH | PNYGHGHHIH | VPQTMSSHPR | 
    850:
    QAPERSAWEL | GIEAGVTAAT | YTPGALHPHL | AHYHAPPRLH | HLQLGALPLM | 
    900:
    VPDMAGYPHI | RYISSGLDGT | SFRGPFRGNF | EELIHLEERL | GNVNRGASQG | 
    950:
    TIERCTYPHK | YKKVTTDWFS | QRKLHCKQDG | EEGTEEDTEE | KCTICLSILE | 
    994:
    EGEDVRRLPC | MHLFHQVCVD | QWLITNKKCP | ICRVDIEAQL | PSES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase Arkadia
    ELISA Kit for Human E3 ubiquitin-protein ligase Arkadia
    CLIA Kit for Human E3 ubiquitin-protein ligase Arkadia
    CLIA Kit for Human E3 ubiquitin-protein ligase Arkadia
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase Arkadia
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase Arkadia
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase Arkadia
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase Arkadia
    Protein for Human E3 ubiquitin-protein ligase Arkadia
    Protein for Human E3 ubiquitin-protein ligase Arkadia

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANT LYS-9
      tissue: Thymus.
      tissue: Tongue.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4);VARIANT LYS-9
      tissue: Amygdala.
      tissue: Endometrium.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 553-994 (ISOFORM 1);VARIANT LYS-9
      tissue: Brain.
      tissue: Colon.
      tissue: Placenta.
    5. 6.
      "Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
      Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
      EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    6. 7.
      "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
      Liu W. , Rui H. , Wang J. , Lin S. , He Y. , Chen M. , Li Q. , Ye Z. , Zhang S. , Chan S.C. , Chen Y.-G. , Han J. , Lin S.-C.
      EMBO J.25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AXIN1 AND AXIN2;IDENTIFICATION IN COMPLEX WITH AXIN1 AND SMAD7;SUBCELLULAR LOCATION;FUNCTION
    7. 8.
      "Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation."
      Levy L. , Howell M. , Das D. , Harkin S. , Episkopou V. , Hill C.S.
      Mol. Cell. Biol.27:6068-6083(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SKIL;FUNCTION
    8. 9.
      "PolySUMO-binding proteins identified through a string search."
      Sun H. , Hunter T.
      J. Biol. Chem.287:42071-42083(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF REPEAT SUMO-INTERACTING MOTIF;INTERACTION WITH SUMO1 AND SUMO2;MUTAGENESIS OF VAL-382; VAL-383; ASP-384; LEU-385 AND THR-386
    9. 10.
      "NMR-based insights into the conformational and interaction properties of Arkadia RING-H2 E3 Ub ligase."
      Chasapis C.T. , Kandias N.G. , Episkopou V. , Bentrop D. , Spyroulias G.A.
      Proteins80:1484-1489(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 927-994;FUNCTION
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