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Index > Protein center > Rnf111(Gene name) > Mouse
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  • Rnf111 (Gene name),
  • E3 ubiquitin-protein ligase Arkadia (Protein name ),  RN111_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Rnf111;
    Protein name:
    E3 ubiquitin-protein ligase Arkadia;
    Alternative:
    RING finger protein 111;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with AXIN1 and AXIN2. Part of a complex containing RNF111, AXIN1 and SMAD7 (By similarity). Interacts with SMAD6 and SMAD7. Interacts with SKIL isoform 1.
    Function:
    Acts in the Nodal pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin-protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.
    Subcellular Location:
    Nucleus Cytoplasm Upon TGF-beta treatment, translocates from nucleus to cytosol.
    Protein Attributes:
    Sequence length:
    989
    Sequence:
    50:
    MSQWTPEFNE | LYTLKVAMKS | GTPDAPTTQE | SLKAVLLHPQ | PLGATKSFPA | 
    100:
    EVEMINSKVG | NEFSHLCDDS | QKQEKDMTGN | QQEQEKSGVV | RKKRKSQQAG | 
    150:
    PSYVQNCVKE | NQEILGRRQQ | LETPSDEDND | SSLSECLSSP | SSSLHFGGSD | 
    200:
    TVTSDEDKEV | SVRHTQPVLS | AKSRSHSARS | HKWPRTEADP | VPSLLMKRPC | 
    250:
    FHGSALRRVT | CRKRLVKSSS | SQRTQKQKER | MLVQRKKREA | LAQRKYALLS | 
    300:
    SSSSSSENDL | SSDSSSSSST | DGEEDLCASA | SENPSNPAAP | SGSIDEDVVV | 
    350:
    IEASFTPQVT | ANEEINVTST | DSEVEIVTVG | ESYRSRSTLG | HSRSHWSQGS | 
    400:
    SSHTGRPQES | RNRSRISTVI | QPLRQNAAEV | VDLTVDEDEP | TIVPTTSARM | 
    450:
    DSQTTSASIN | NSNPSTSEQA | SDTTSTVASS | QPSTVSETEA | TLTSNSATGS | 
    500:
    SVGDDVRRTA | SSAVPESGPP | AMPRLPSCCP | QHSPCGGTSQ | SHHALAHPHS | 
    550:
    SCFQQHGHHF | QHHHHHHHTP | HPAVPVSPSF | SDPACPVERP | QVQAPCGANS | 
    600:
    SSGSSYHDQQ | ALPVDLSNSA | LRTHGSGGFH | GASAFDPCCP | VTSSRAAVFG | 
    650:
    HQAAAAPTQP | LSIDGYGSSM | VAQPQPQPPP | QPSLSSCRHY | MPPPYASLTR | 
    700:
    PLHHQASACH | HSHGNAPPQT | QPPPQVDYVI | PHPVHAFHSQ | ISSHAASHPV | 
    750:
    APPPPTHLGS | TAAPIPQHLP | PAHQPISHHI | PAPAPSAQRL | HPHEVMQRME | 
    800:
    VQRRRMMQHP | TRAHERPPPH | PHRMHPNYGH | GHHIHVPQTM | SSHPRQAPER | 
    850:
    TAWELGIEAG | VTAATYTPGA | LHPHLAHYHA | PPRLHHLQLG | ALPLMVPDMA | 
    900:
    GYPHIRYISS | GLDGASFRGP | FRGNFEELIH | LEERLGNVNR | GASQGTIERC | 
    950:
    TYPHKYKKVT | TDWFSQRKLH | CKQDGEEGTE | EDTEEKCTIC | LSILEEGEDV | 
    989:
    RRLPCMHLFH | QVCVDQWLIT | NKKCPICRVD | IEAQLPSES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    SMR:
    KEGG:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse E3 ubiquitin-protein ligase Arkadia
    ELISA Kit for Mouse E3 ubiquitin-protein ligase Arkadia
    CLIA Kit for Mouse E3 ubiquitin-protein ligase Arkadia
    CLIA Kit for Mouse E3 ubiquitin-protein ligase Arkadia
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Arkadia
    Polyclonal Antibody for Mouse E3 ubiquitin-protein ligase Arkadia
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Arkadia
    Monoclonal Antibody for Mouse E3 ubiquitin-protein ligase Arkadia
    Protein for Mouse E3 ubiquitin-protein ligase Arkadia
    Protein for Mouse E3 ubiquitin-protein ligase Arkadia

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages."
      Episkopou V. , Arkell R. , Timmons P.M. , Walsh J.J. , Andrew R.L. , Swan D.
      Nature410:825-830(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
      strain: 129/Sv.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Head.
      tissue: Urinary bladder.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 805-989 (ISOFORM 1)
      strain: CD-1.
      strain: FVB/N-3.
      tissue: Mammary tumor.
      tissue: Neural stem cell.
    4. 4.
      "Arkadia amplifies TGF-beta superfamily signaling through degradation of Smad7."
      Koinuma D. , Shinozaki M. , Komuro A. , Goto K. , Saitoh M. , Hanyu A. , Ebina M. , Nukiwa T. , Miyazawa K. , Imamura T. , Miyazono K.
      EMBO J.22:6458-6470(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-937;INTERACTION WITH SMAD6 AND SMAD7;SUBCELLULAR LOCATION
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