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Index > Protein center > Rnf123(Gene name) > Rat
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  • Rnf123 (Gene name),
  • E3 ubiquitin-protein ligase RNF123 (Protein name ),  RN123_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Rnf123(Kpc1);
    Protein name:
    E3 ubiquitin-protein ligase RNF123;
    Alternative:
    RING finger protein 123;Kip1 ubiquitination-promoting complex protein 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with UBAC1 and CDKN1B via its N-terminal domain.
    Function:
    Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    1318
    Sequence:
    50:
    MTSKGAAMSF | SRKSYRLTSD | AEKSRVTGIV | QEKLLSDYLY | RIFSSPDHGT | 
    100:
    PAATSRKPLN | FHNLPEHVDQ | LLQVDDEESQ | GQVEGRLGPS | TVVLDHTGGF | 
    150:
    EGLLLVDDDL | LGVIGHSNFG | TIRSSTCVYK | GKWVYEVLIS | SQGLMQIGWC | 
    200:
    TINCRFNQEE | GVGDTHNSYA | YDGNRVRKWN | VTTTNYGKAW | AAGDIVSCLI | 
    250:
    DLDDGTLSFC | LNGVSLGTAF | ENLSRGLGMA | YFPAISLSFK | ESVAFNFGSR | 
    300:
    PLRYPVAGFR | PLQDPPFADL | VRAQRLLGCF | QTVLSVELDP | VEGRLVEKES | 
    350:
    SEWQLHGQPT | VLLTLAHIFH | HFAPLLRKVY | LVEAVLMSFL | LGIVEKGTPE | 
    400:
    QAQSVVHQIL | DLLWLFMEDY | EVQDCLKQLM | MSLLRLYRFS | PIVPDLGLQI | 
    450:
    HYLRLTMAVL | RHEKSRKFLL | SNVLFDMLRS | VVFFYIKSPL | RVEEAGLKEL | 
    500:
    IPTTWWPHRS | SREGRDGQEA | KEETTEERQR | RRAYERGCQR | LKKRIEVVEE | 
    550:
    LQVQILKLLL | DNKDDNGGEA | SRYIFLTKFR | KFLQENASGR | GNTPVLCPPE | 
    600:
    YMVCFLHRLV | SALRFYWDEY | KASNPRASFS | DEAYIPPQIF | YNGKVDYFDL | 
    650:
    QRLGGLLSHL | RKTLKDDLAS | KANIVIDPLE | LQAATMDDLD | EDEEPAPTAA | 
    700:
    QSWRARQRPV | QALAIGGALP | LPRPGWLSSP | TLGRANRFLS | TAAVSLMTPR | 
    750:
    RLLSTMEKVK | VRSLNVEQRT | REDIEGSHWN | EGLLLGRPPE | EPERPLTENS | 
    800:
    LLEVLDGTVM | MYSLSVHQQL | GKMVGVSDDV | NEYAMALRDT | EDKLRRCPKR | 
    850:
    RKDILAELTK | SQKVFSEKLD | HLSRRLAWVH | ATVYSQEKML | DIYWLLRVCL | 
    900:
    QTIEHGDRTG | SLFAFMPEFY | LSVAINSYSA | LKNYFGPVHS | MEELPGYEET | 
    950:
    LTRLAAILAK | HFADPRIVGT | DIRDSLMQAL | ASYVCYPHSL | RAVERIPEEQ | 
    1000:
    RIAMVRNLLA | PYEQRPWAQT | NWILVRLWRG | CGFGYRYTRL | PHLLKTKPED | 
    1050:
    ANLPSLQKPC | PSTLLQQHMA | DLLRQGSDVA | PSFLNSVLNQ | LNWAFSEFIG | 
    1100:
    MIQEIQQAAE | RLERNFVDSR | QLKVCATCFD | LSVSLLRVLE | MTITLVPEIF | 
    1150:
    LDWSRPTSEM | LLRRLAQLLN | QVLNRVTAER | NLFDRVVTLR | LPGLESVDHY | 
    1200:
    PILVAVTGIL | VRLLAHGPSS | ETEQATSVLL | ADPCFQLRSI | RYLLGQPEPL | 
    1250:
    APGSALPAPD | RKRFSLQSYA | DYISAEELAQ | VERMLAHLTA | ASAQAAAASL | 
    1300:
    PTNEEDLCPI | CYAHPISAVF | QPCGHKSCKA | CINQHLMNNK | DCFFCKATIV | 
    1318:
    SVEDWDKAAS | TSATSSAA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Rat E3 ubiquitin-protein ligase RNF123
    ELISA Kit for Rat E3 ubiquitin-protein ligase RNF123
    ELISA Kit for Rat E3 ubiquitin-protein ligase RNF123
    CLIA Kit for Rat E3 ubiquitin-protein ligase RNF123
    CLIA Kit for Rat E3 ubiquitin-protein ligase RNF123
    CLIA Kit for Rat E3 ubiquitin-protein ligase RNF123
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase RNF123
    Protein for Rat E3 ubiquitin-protein ligase RNF123
    Protein for Rat E3 ubiquitin-protein ligase RNF123
    Protein for Rat E3 ubiquitin-protein ligase RNF123

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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
    2. 2.
      "USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1."
      Lu Y. , Adegoke O.A.J. , Nepveu A. , Nakayama K.I. , Bedard N. , Cheng D. , Peng J. , Wing S.S.
      Mol. Cell. Biol.29:547-558(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: UBIQUITINATION;DEUBIQUITINATION BY USP19
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