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Index > Protein center > RNF34(Gene name) > Human
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  • RNF34 (Gene name),
  • E3 ubiquitin-protein ligase RNF34 (Protein name ),  RNF34_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    RNF34;
    Protein name:
    E3 ubiquitin-protein ligase RNF34;
    Alternative:
    Caspases-8 and -10-associated RING finger protein 1(CARP-1);Caspase regulator CARP1;Human RING finger homologous to inhibitor of apoptosis protein(hRFI);FYVE-RING finger protein Momo;RING finger protein RIFF;RING finger protein 34;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with DNAJA3 (Potential). Interacts with CASP8 and CASP10.
    Function:
    Has E3 ubiquitin-protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Protects cells against apoptosis induced by TNF. Binds phosphatidylinositol-5-phosphate and phosphatidylinositol-3-phosphate.
    Subcellular Location:
    Nucleus speckle Endomembrane system Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    372
    Sequence:
    50:
    MKAGATSMWA | SCCGLLNEVM | GTGAVRGQQS | AFAGATGPFR | FTPNPEFSTY | 
    100:
    PPAATEGPNI | VCKACGLSFS | VFRKKHVCCD | CKKDFCSVCS | VLQENLRRCS | 
    150:
    TCHLLQETAF | QRPQLMRLKV | KDLRQYLILR | NIPIDTCREK | EDLVDLVLCH | 
    200:
    HGLGSEDDMD | TSSLNSSRSQ | TSSFFTRSFF | SNYTAPSATM | SSFQGELMDG | 
    250:
    DQTSRSGVPA | QVQSEITSAN | TEDDDDDDDE | DDDDEEENAE | DRNPGLSKER | 
    300:
    VRASLSDLSS | LDDVEGMSVR | QLKEILARNF | VNYSGCCEKW | ELVEKVNRLY | 
    350:
    KENEENQKSY | GERLQLQDEE | DDSLCRICMD | AVIDCVLLEC | GHMVTCTKCG | 
    372:
    KRMSECPICR | QYVVRAVHVF | KS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    String:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF34
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF34
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF34
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF34
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF34
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF34
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF34
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF34
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF34
    Protein for Human E3 ubiquitin-protein ligase RNF34
    Protein for Human E3 ubiquitin-protein ligase RNF34
    Protein for Human E3 ubiquitin-protein ligase RNF34
    Protein for Human E3 ubiquitin-protein ligase RNF34

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of a novel gene, hRFI, preferentially expressed in esophageal cancer."
      Sasaki S. , Nakamura T. , Arakawa H. , Mori M. , Watanabe T. , Nagawa H. , Croce C.M.
      Oncogene21:5024-5030(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;SUBCELLULAR LOCATION;CLEAVAGE BY CASPASE-3;TISSUE SPECIFICITY
    2. 2.
      "Cloning of RIFF, a novel RING finger FYVE finger protein expressed in human fetal brain."
      Olsson P.-A. , Lindholm D.
      Submitted (2000-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    3. 3.
      Kanbe D. , Araki K. , Nawa H.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Trachea.
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    8. 8.
      "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth."
      McDonald E.R. III , El-Deiry W.S.
      Proc. Natl. Acad. Sci. U.S.A.101:6170-6175(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CASP8 AND CASP10;MUTAGENESIS OF HIS-342;PROTEOLYTIC DEGRADATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    9. 9.
      "Overexpression of hRFI (human RING finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells."
      Konishi T. , Sasaki S. , Watanabe T. , Kitayama J. , Nagawa H.
      Mol. Cancer Ther.4:743-750(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "CARPs are ubiquitin ligases that promote MDM2-independent p53 and phospho-p53ser20 degradation."
      Yang W. , Rozan L.M. , McDonald E.R. III , Navaraj A. , Liu J.J. , Matthew E.M. , Wang W. , Dicker D.T. , El-Deiry W.S.
      J. Biol. Chem.282:3273-3281(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH P53/TP53
    11. 11.
      "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2."
      Yang W. , Dicker D.T. , Chen J. , El-Deiry W.S.
      Cell Cycle7:670-682(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MDM2 AND P53/TP53
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Response: CARP1 regulates induction of NF-kappaB by TNFalpha."
      Liao W. , Fujita K. , Xiao Q. , Tchikov V. , Yang W. , Gunsor M. , Garfield S. , Goldsmith P. , El-Deiry W.S. , Schuetze S. , Srinivasula S.M.
      Curr. Biol.19:R17-R19(2009)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RIPK1;PATHWAY
    14. 14.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-254;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "RNF34 is a cold-regulated E3 ubiquitin ligase for PGC-1alpha and modulates brown fat cell metabolism."
      Wei P. , Pan D. , Mao C. , Wang Y.X.
      Mol. Cell. Biol.32:266-275(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPARGC1A;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-328
    17. 17.
      "The E3 ligase RNF34 is a novel negative regulator of the NOD1 pathway."
      Zhang R. , Zhao J. , Song Y. , Wang X. , Wang L. , Xu J. , Song C. , Liu F.
      Cell. Physiol. Biochem.33:1954-1962(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NOD1
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