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Index > Protein center > RNF6(Gene name) > Human
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  • RNF6 (Gene name),
  • E3 ubiquitin-protein ligase RNF6 (Protein name ),  RNF6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    RNF6(SPG2);
    Protein name:
    E3 ubiquitin-protein ligase RNF6;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with LIMK1 (By similarity). Interacts with AR.
    Function:
    E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.
    Subcellular Location:
    Nucleus Cytoplasm Cell projection axon Nucleus PML body Localizes to the PML nuclear bodies in Sertoli cells.
    Protein Attributes:
    Sequence length:
    685
    Sequence:
    50:
    MNQSRSRSDG | GSEETLPQDH | NHHENERRWQ | QERLHREEAY | YQFINELNDE | 
    100:
    DYRLMRDHNL | LGTPGEITSE | ELQQRLDGVK | EQLASQPDLR | DGTNYRDSEV | 
    150:
    PRESSHEDSL | LEWLNTFRRT | GNATRSGQNG | NQTWRAVSRT | NPNNGEFRFS | 
    200:
    LEIHVNHENR | GFEIHGEDYT | DIPLSDSNRD | HTANRQQRST | SPVARRTRSQ | 
    250:
    TSVNFNGSSS | NIPRTRLASR | GQNPAEGSFS | TLGRLRNGIG | GAAGIPRANA | 
    300:
    SRTNFSSHTN | QSGGSELRQR | EGQRFGAAHV | WENGARSNVT | VRNTNQRLEP | 
    350:
    IRLRSTSNSR | SRSPIQRQSG | TVYHNSQRES | RPVQQTTRRS | VRRRGRTRVF | 
    400:
    LEQDRERERR | GTAYTPFSNS | RLVSRITVEE | GEESSRSSTA | VRRHPTITLD | 
    450:
    LQVRRIRPGE | NRDRDSIANR | TRSRVGLAEN | TVTIESNSGG | FRRTISRLER | 
    500:
    SGIRTYVSTI | TVPLRRISEN | ELVEPSSVAL | RSILRQIMTG | FGELSSLMEA | 
    550:
    DSESELQRNG | QHLPDMHSEL | SNLGTDNNRS | QHREGSSQDR | QAQGDSTEMH | 
    600:
    GENETTQPHT | RNSDSRGGRQ | LRNPNNLVET | GTLPILRLAH | FFLLNESDDD | 
    650:
    DRIRGLTKEQ | IDNLSTRHYE | HNSIDSELGK | ICSVCISDYV | TGNKLRQLPC | 
    685:
    MHEFHIHCID | RWLSENCTCP | ICRQPVLGSN | IANNG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF6
    ELISA Kit for Human E3 ubiquitin-protein ligase RNF6
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF6
    CLIA Kit for Human E3 ubiquitin-protein ligase RNF6
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF6
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase RNF6
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF6
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase RNF6
    Protein for Human E3 ubiquitin-protein ligase RNF6
    Protein for Human E3 ubiquitin-protein ligase RNF6

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12."
      Macdonald D.H.C. , Lahiri D. , Sampath A. , Chase A. , Sohal J. , Cross N.C.P.
      Genomics58:94-97(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Leukocyte.
    2. 2.
      "Alternative splice variant of the RING-H2 protein RNF6 lacks the RING-H2 domain."
      Alao J.P. , Grand F.H. , MacDonald D.H.C.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);ALTERNATIVE SPLICING
    3. 3.
      "Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development."
      Zhu L. , Tong G. , Chen J. , Wang Y. , Wang S. , Zhao M. , Li J. , Ma J.
      Sci. China, Ser. C, Life Sci.51:302-307(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
      tissue: Testis.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    5. 5.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Testis.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 320-685 (ISOFORM 1)
      tissue: Testis.
    9. 9.
      "Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination."
      Xu K. , Shimelis H. , Linn D.E. , Jiang R. , Yang X. , Sun F. , Guo Z. , Chen H. , Li W. , Chen H. , Kong X. , Melamed J. , Fang S. , Xiao Z. , Veenstra T.D. , Qiu Y.
      Cancer Cell15:270-282(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH AR;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    10. 10.
      "Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma."
      Lo H.S. , Hu N. , Gere S. , Lu N. , Su H. , Goldstein A.M. , Taylor P.R. , Lee M.P.
      Cancer Res.62:4191-4193(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ESCR;VARIANTS SER-48; LYS-102; THR-164; THR-242; ASP-244; GLN-572 AND ASN-623
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