Gene name:
HNRNPA1 (HNRPA1) ;
Protein name:
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) ;
Alternative:
Single-strand RNA-binding protein ;Helix-destabilizing protein ;hnRNP core protein A1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA.
Function:
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
Subcellular Location:
Nucleus
Cytoplasm
Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner.
Protein Attributes:
50:
MSKSESPKEP | EQLRKLFIGG | LSFETTDESL | RSHFEQWGTL | TDCVVMRDPN |
100:
TKRSRGFGFV | TYATVEEVDA | AMNARPHKVD | GRVVEPKRAV | SREDSQRPGA |
150:
HLTVKKIFVG | GIKEDTEEHH | LRDYFEQYGK | IEVIEIMTDR | GSGKKRGFAF |
200:
VTFDDHDSVD | KIVIQKYHTV | NGHNCEVRKA | LSKQEMASAS | SSQRGRSGSG |
250:
NFGGGRGGGF | GGNDNFGRGG | NFSGRGGFGG | SRGGGGYGGS | GDGYNGFGND |
300:
GGYGGGGPGY | SGGSRGYGSG | GQGYGNQGSG | YGGSGSYDSY | NNGGGGGFGG |
350:
GSGSNFGGGG | SYNDFGNYNN | QSSNFGPMKG | GNFGGRSSGP | YGGGGQYFAK |
372:
PRNQGGYGGS | SSSSSYGSGR | RF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Bovine
Human
ELISA Kit for Human hnRNP A1
ELISA Kit for Human hnRNP A1
ELISA Kit for Human hnRNP A1
ELISA Kit for Human hnRNP A1
CLIA Kit for Human hnRNP A1
CLIA Kit for Human hnRNP A1
CLIA Kit for Human hnRNP A1
CLIA Kit for Human hnRNP A1
Polyclonal Antibody for Human hnRNP A1
Polyclonal Antibody for Human hnRNP A1
Polyclonal Antibody for Human hnRNP A1
Polyclonal Antibody for Human hnRNP A1
Monoclonal Antibody for Human hnRNP A1
Monoclonal Antibody for Human hnRNP A1
Monoclonal Antibody for Human hnRNP A1
Monoclonal Antibody for Human hnRNP A1
Protein for Human hnRNP A1
Protein for Human hnRNP A1
Protein for Human hnRNP A1
Protein for Human hnRNP A1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A1-A)
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Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1-A)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A1-A)
tissue :
Lung .
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Nat. Genet.36:40-45(2004)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A1-A)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A1-A AND 2)
tissue :
Bone marrow .
tissue :
Cervix .
tissue :
Eye .
tissue :
Kidney .
tissue :
Liver .
tissue :
Lung .
tissue :
Lymph .
8.
"Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1."
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Morandi C.
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Williams K.R.
,
Multhaup G.
,
Beyreuther K.
,
Werr H.
,
Heinrich B.
,
Schaefer K.P.
EMBO J.5:2267-2273(1986)
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PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Liver .
9.
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Cited for : PROTEIN SEQUENCE OF 2-47; 56-78; 93-140; 146-178; 197-232 AND 337-370;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;METHYLATION AT ARG-206 AND ARG-225;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Cervix carcinoma .
tissue :
Ovarian carcinoma .
10.
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Cited for : PROTEIN SEQUENCE OF 15-47; 147-161 AND 353-370;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Fetal brain cortex .
11.
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Cited for : NUCLEOTIDE SEQUENCE OF 252-303 (ISOFORM A1-B)
12.
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Cited for : NUCLEAR LOCALIZATION SIGNAL;MUTAGENESIS OF GLY-326; PRO-327 AND 334-GLY-GLY-335
13.
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Cited for : NUCLEAR LOCALIZATION SIGNAL;NUCLEAR EXPORT
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEAR LOCALIZATION SIGNAL
15.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
16.
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Cited for : METHYLATION [LARGE SCALE ANALYSIS] AT ARG-194; ARG-206 AND ARG-225;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
"Sumoylation of heterogeneous nuclear ribonucleoproteins, zinc finger proteins, and nuclear pore complex proteins: a proteomic analysis."
Li T.
,
Evdokimov E.
,
Shen R.F.
,
Chao C.C.
,
Tekle E.
,
Wang T.
,
Stadtman E.R.
,
Yang D.C.
,
Chock P.B.
Proc. Natl. Acad. Sci. U.S.A.101:8551-8556(2004)
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PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : SUMOYLATION AT LYS-113
18.
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Cited for : PHOSPHORYLATION AT SER-192; SER-362; SER-363 AND SER-364 BY MKNK2
19.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
20.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
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Cited for : INTERACTION WITH SEPT6 AND HCV NS5B;FUNCTION;SUBCELLULAR LOCATION
22.
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Cited for : IDENTIFICATION IN A MRNP GRANULE COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION
23.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
T-cell .
24.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-368;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
25.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
27.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2; LYS-3 AND LYS-350;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-4 AND SER-6;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
29.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4; SER-6; SER-199; SER-365 AND SER-368;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
31.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
32.
"C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking."
Farg M.A.
,
Sundaramoorthy V.
,
Sultana J.M.
,
Yang S.
,
Atkinson R.A.
,
Levina V.
,
Halloran M.A.
,
Gleeson P.A.
,
Blair I.P.
,
Soo K.Y.
,
King A.E.
,
Atkin J.D.
Hum. Mol. Genet.23:3579-3595(2014)
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PubMed ]
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Europe PMC ]
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Abstract ]
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Cited for : INTERACTION WITH C9ORF72
33.
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Cited for : 3D-STRUCTURE MODELING OF 107-190
34.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 9-181
35.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 7-182
36.
"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS."
Kim H.J.
,
Kim N.C.
,
Wang Y.D.
,
Scarborough E.A.
,
Moore J.
,
Diaz Z.
,
MacLea K.S.
,
Freibaum B.
,
Li S.
,
Molliex A.
,
Kanagaraj A.P.
,
Carter R.
,
Boylan K.B.
,
Wojtas A.M.
,
Rademakers R.
,
Pinkus J.L.
,
Greenberg S.A.
,
Trojanowski J.Q.
,
Traynor B.J.
,
Smith B.N.
,
Topp S.
,
Gkazi A.S.
,
Miller J.
,
Shaw C.E.
,
Kottlors M.
,
Kirschner J.
,
Pestronk A.
,
Li Y.R.
,
Ford A.F.
,
Gitler A.D.
,
Benatar M.
,
King O.D.
,
Kimonis V.E.
,
Ross E.D.
,
Weihl C.C.
,
Shorter J.
,
Taylor J.P.
more...
Nature495:467-473(2013)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANT IBMPFD3 VAL-314;VARIANTS ALS20 ASN-314 AND SER-319