ROCK1 ELISA Kit for Bovine(Bos taurus) | EIAab.comROCK1 ELISA Kit for Bovine(Bos taurus)

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ROCK1 (Gene name),

Rho-associated protein kinase 1 (Protein name ), ROCK1_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ROCK1;

Protein name:

Rho-associated protein kinase 1;

Alternative:

Rho-associated, coiled-coil-containing protein kinase I(ROCK-I);Rho-associated, coiled-coil-containing protein kinase 1;p160 ROCK-1(p160ROCK);

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner.

Function:

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Subcellular Location:

Cytoplasm Golgi apparatus membrane Peripheral membrane protein Cytoplasm cytoskeleton centrosome centriole Cell projection bleb A small proportion is associated with Golgi membranes (By similarity). Associated with the mother centriole and an intercentriolar linker.

Protein Attributes:

Sequence length:

441

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

441:

TERTLKTQAV | NKLAEIMNRK | DFKIDRKKAN | TQDLRKKKKK | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9913.ENSBTAP00000053818

String:

Q8MIT6

Pfam:

PF08912

UniGene:

Bt.65075

SMR:

Q8MIT6

Uniprot:

Q8MIT6

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ELISA Kit for Bovine Rho-associated protein kinase 1

Cat.:

E15189h

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Manual:

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96T

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ELISA Kit for Bovine Rho-associated protein kinase 1

Cat.:

E15189r

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96T

ELISA Kit for Bovine Rho-associated protein kinase 1

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ELISA Kit for Bovine Rho-associated protein kinase 1

Cat.:

E15189m

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96T

ELISA Kit for Bovine Rho-associated protein kinase 1

Cat.:

E15189b

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Packing:

96T

CLIA Kit for Bovine Rho-associated protein kinase 1

Cat.:

U15189r

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96T

CLIA Kit for Bovine Rho-associated protein kinase 1

Cat.:

U15189h

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MSDS:

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Packing:

96T

CLIA Kit for Bovine Rho-associated protein kinase 1

MSDS:

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CLIA Kit for Bovine Rho-associated protein kinase 1

Cat.:

U15189b

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MSDS:

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Packing:

96T

CLIA Kit for Bovine Rho-associated protein kinase 1

Cat.:

U15189m

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96T

Polyclonal Antibody for Bovine Rho-associated protein kinase 1

Cat.:

P15189Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine Rho-associated protein kinase 1

Cat.:

P15189Rb-h

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40ug/0.2ml

Polyclonal Antibody for Bovine Rho-associated protein kinase 1

Cat.:

P15189Rb-r

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40ug/0.2ml

Polyclonal Antibody for Bovine Rho-associated protein kinase 1

Monoclonal Antibody for Bovine Rho-associated protein kinase 1

Protein for Bovine Rho-associated protein kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The Rho-associated protein kinase p160ROCK is required for centrosome positioning."
Chevrier V. , Piel M. , Collomb N. , Saoudi Y. , Frank R. , Paintrand M. , Narumiya S. , Bornens M. , Job D.
J. Cell Biol.157:807-817(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION
tissue: Kidney.
2.

"Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase."
Kosako H. , Amano M. , Yanagida M. , Tanabe K. , Nishi Y. , Kaibuchi K. , Inagaki M.
J. Biol. Chem.272:10333-10336(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
3.

"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension."
Uehata M. , Ishizaki T. , Satoh H. , Ono T. , Kawahara T. , Morishita T. , Tamakawa H. , Yamagami K. , Inui J. , Maekawa M. , Narumiya S.
Nature389:990-994(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;INHIBITION BY Y-27632;FUNCTION

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