ROCK1;

Rho-associated protein kinase 1;

HEBM1;Corneal epithelial Rho-associated-Ser/Thr kinase 1;Rho-associated, coiled-coil-containing protein kinase I(ROCK-I);Rho-associated, coiled-coil-containing protein kinase 1;p160 ROCK-1(p160ROCK);cAMP-dependent protein kinase ROCK-I(CePKA);

Rabbit (Oryctolagus cuniculus). 

Homodimer (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC, GEM, MYLC2B, RHOE, PPP1R12A, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner.

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes.

1354

N/A

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O77819

9986.ENSOCUP00000004197

Ocu.2220

O77819

PF02185