Rock1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comRock1 ELISA Kit for Rat(Rattus norvegicus)

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Rock1 (Gene name),

Rho-associated protein kinase 1 (Protein name ), ROCK1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rock1(Ac2-154);

Protein name:

Rho-associated protein kinase 1;

Alternative:

Rho-associated, coiled-coil-containing protein kinase 1;Liver regeneration-related protein LRRG199;p150 RhoA-binding kinase ROK beta;Rho-associated, coiled-coil-containing protein kinase I(ROCK-I);p160 ROCK-1(p160ROCK);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with GEM, MYLC2B, RHOE, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC and PPP1R12A.

Function:

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation.

Subcellular Location:

Cytoplasm Cytoplasm cytoskeleton centrosome centriole Golgi apparatus membrane Peripheral membrane protein Cell projection bleb Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes.

Protein Attributes:

Sequence length:

1369

Sequence:

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1150:

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1250:

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1350:

1369:

STANQSFRKV | VKNTSGKTS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:81762

UniGene:

Rn.89756

STRING:

10116.ENSRNOP00000049511

SMR:

Q63644

String:

Q63644

Pfam:

PF02185

Uniprot:

Q63644

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ELISA Kit for Rat Rho-associated protein kinase 1

Cat.:

E15189h

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96T

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ELISA Kit for Rat Rho-associated protein kinase 1

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E15189r

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96T

ELISA Kit for Rat Rho-associated protein kinase 1

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ELISA Kit for Rat Rho-associated protein kinase 1

Cat.:

E15189m

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96T

ELISA Kit for Rat Rho-associated protein kinase 1

Cat.:

E15189b

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96T

CLIA Kit for Rat Rho-associated protein kinase 1

Cat.:

U15189r

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96T

CLIA Kit for Rat Rho-associated protein kinase 1

Cat.:

U15189h

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MSDS:

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Packing:

96T

CLIA Kit for Rat Rho-associated protein kinase 1

MSDS:

Please sign in first.

CLIA Kit for Rat Rho-associated protein kinase 1

Cat.:

U15189b

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat Rho-associated protein kinase 1

Cat.:

U15189m

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96T

Polyclonal Antibody for Rat Rho-associated protein kinase 1

Cat.:

P15189Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat Rho-associated protein kinase 1

Cat.:

P15189Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat Rho-associated protein kinase 1

Cat.:

P15189Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat Rho-associated protein kinase 1

Monoclonal Antibody for Rat Rho-associated protein kinase 1

Protein for Rat Rho-associated protein kinase 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton."
Leung T. , Chen X.-Q. , Manser E. , Lim L.
Mol. Cell. Biol.16:5313-5327(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH RHOA; RHOB AND RHOC;TISSUE SPECIFICITY
tissue: Brain.
tissue: Liver.
2.

"Liver regeneration after PH."
Xu C.S. , Li W.Q. , Li Y.C. , Yang K.J. , Yan H.M. , Chang C.F. , Zhao L.F. , Ma H. , Wang L. , Wang S.F. , Han H.P. , Wang G.P. , Chai L.Q. , Yuan J.Y. , Shi J.B. , Rahman S. , Wang Q.N. , Zhang J.B.
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Liver.
3.

"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension."
Uehata M. , Ishizaki T. , Satoh H. , Ono T. , Kawahara T. , Morishita T. , Tamakawa H. , Yamagami K. , Inui J. , Maekawa M. , Narumiya S.
Nature389:990-994(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ROLE IN SMOOTH MUSCLE CONTRACTION AND HYPERTENSION;INHIBITION BY Y-27632
4.

"ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells."
Wang Y. , Zheng X.R. , Riddick N. , Bryden M. , Baur W. , Zhang X. , Surks H.K.
Circ. Res.104:531-540(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP1R12A;SUBCELLULAR LOCATION

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