ROCK2 ELISA Kit for Bovine(Bos taurus) | EIAab.comROCK2 ELISA Kit for Bovine(Bos taurus)

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ROCK2 (Gene name),

Rho-associated protein kinase 2 (Protein name ), ROCK2_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ROCK2;

Protein name:

Rho-associated protein kinase 2;

Alternative:

Rho-associated, coiled-coil-containing protein kinase II(ROCK-II);Rho-associated, coiled-coil-containing protein kinase 2;p164 ROCK-2;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, IRS1, RHOB, RHOC, PPP1R12A, SORL1, EP300 and BRCA2 (By similarity). Interacts with NPM1 and this interaction enhances its activity.

Function:

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK (RPS6KA1) during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus.

Subcellular Location:

Cytoplasm Cell membrane Peripheral membrane protein Nucleus Cytoplasm cytoskeleton centrosome Cytoplasmic, and associated with actin microfilaments and the plasma membrane.

Protein Attributes:

Sequence length:

1388

Sequence:

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1388:

KPPAPDPFAR | SSPRTSMKIQ | QNQSIRRPSR | QLAPNKPS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

bta:282041

UniGene:

Bt.120

String:

Q28021

SMR:

Q28021

Pfam:

PF02185

Uniprot:

Q28021

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ELISA Kit for Bovine Rho-associated protein kinase 2

Cat.:

E1852h

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96T

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ELISA Kit for Bovine Rho-associated protein kinase 2

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E1852m

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96T

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ELISA Kit for Bovine Rho-associated protein kinase 2

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E1852r

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96T

ELISA Kit for Bovine Rho-associated protein kinase 2

Cat.:

E1852b

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96T

CLIA Kit for Bovine Rho-associated protein kinase 2

Cat.:

U1852b

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96T

CLIA Kit for Bovine Rho-associated protein kinase 2

Cat.:

U1852h

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Manual:

Looking for manual.

MSDS:

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96T

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CLIA Kit for Bovine Rho-associated protein kinase 2

Cat.:

U1852m

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96T

CLIA Kit for Bovine Rho-associated protein kinase 2

Cat.:

U1852r

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96T

Polyclonal Antibody for Bovine Rho-associated protein kinase 2

Cat.:

P1852Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine Rho-associated protein kinase 2

Cat.:

P1852Rb-r

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40ug/0.2ml

Polyclonal Antibody for Bovine Rho-associated protein kinase 2

Cat.:

P1852Rb-h

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Monoclonal Antibody for Bovine Rho-associated protein kinase 2

Protein for Bovine Rho-associated protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho."
Matsui T. , Amano M. , Yamamoto T. , Chihara K. , Nakafuku M. , Ito M. , Nakano T. , Okawa K. , Iwamatsu A. , Kaibuchi K.
EMBO J.15:2208-2216(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 10-18; 30-44; 58-64; 133-140; 248-252; 291-305; 327-348; 350-360; 366-384; 392-400; 506-511; 527-535; 590-604; 633-652; 670-681; 829-842; 861-872; 913-921; 947-950; 979-988; 1066-1070; 1087-1091; 1114-1120; 1131-1141; 1145-1151; 1158-1166; 1182-1191; 1198-1218 AND 1318-1325;FUNCTION;INTERACTION WITH RHOA;PHOSPHORYLATION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
2.

"Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)."
Amano M. , Ito M. , Kimura K. , Fukata Y. , Chihara K. , Nakano T. , Matsuura Y. , Kaibuchi K.
J. Biol. Chem.271:20246-20249(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
3.

"Phosphorylation of vimentin by Rho-associated kinase at a unique amino-terminal site that is specifically phosphorylated during cytokinesis."
Goto H. , Kosako H. , Tanabe K. , Yanagida M. , Sakurai M. , Amano M. , Kaibuchi K. , Inagaki M.
J. Biol. Chem.273:11728-11736(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association."
Matsui T. , Maeda M. , Doi Y. , Yonemura S. , Amano M. , Kaibuchi K. , Tsukita S. , Tsukita S.
J. Cell Biol.140:647-657(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility."
Fukata Y. , Oshiro N. , Kinoshita N. , Kawano Y. , Matsuoka Y. , Bennett V. , Matsuura Y. , Kaibuchi K.
J. Cell Biol.145:347-361(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Identification of calponin as a novel substrate of Rho-kinase."
Kaneko T. , Amano M. , Maeda A. , Goto H. , Takahashi K. , Ito M. , Kaibuchi K.
Biochem. Biophys. Res. Commun.273:110-116(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse."
Arimura N. , Inagaki N. , Chihara K. , Menager C. , Nakamura N. , Amano M. , Iwamatsu A. , Goshima Y. , Kaibuchi K.
J. Biol. Chem.275:23973-23980(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase."
Shimizu T. , Ihara K. , Maesaki R. , Amano M. , Kaibuchi K. , Hakoshima T.
J. Biol. Chem.278:46046-46051(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 979-1047 IN COMPLEX WITH RHOA;HOMODIMERIZATION

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