Rock2 ELISA Kit for Mouse(Mus musculus) | EIAab.comRock2 ELISA Kit for Mouse(Mus musculus)

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Rock2 (Gene name),

Rho-associated protein kinase 2 (Protein name ), ROCK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Rock2;

Protein name:

Rho-associated protein kinase 2;

Alternative:

Rho-associated, coiled-coil-containing protein kinase II(ROCK-II);Rho-associated, coiled-coil-containing protein kinase 2;p164 ROCK-2;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer (By similarity). Interacts with RHOA (activated by GTP), CHORDC1, IRS1, RHOB, RHOC, PPP1R12A, SORL1, EP300 and BRCA2 (By similarity). Interacts with NPM1 and this interaction enhances its activity.

Function:

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK (RPS6KA1) during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays a role in placental homeostasis during the perinatal period.

Subcellular Location:

Isoform 2 Cytoplasm Cell membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

1388

Sequence:

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1350:

1388:

KPPAPDPFAR | SSPRTSMKIQ | QNQSIRRPSR | QLAPNKPS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P70336

Pfam:

PF00169

KEGG:

mmu:19878

UniGene:

Mm.276024

String:

P70336

Pfam:

PF02185

Uniprot:

P70336

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ELISA Kit for Mouse Rho-associated protein kinase 2

Cat.:

E1852h

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96T

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ELISA Kit for Mouse Rho-associated protein kinase 2

Cat.:

E1852m

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96T

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ELISA Kit for Mouse Rho-associated protein kinase 2

Cat.:

E1852r

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96T

ELISA Kit for Mouse Rho-associated protein kinase 2

Cat.:

E1852b

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Packing:

96T

CLIA Kit for Mouse Rho-associated protein kinase 2

Cat.:

U1852b

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Rho-associated protein kinase 2

Cat.:

U1852h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Rho-associated protein kinase 2

Cat.:

U1852m

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MSDS:

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96T

CLIA Kit for Mouse Rho-associated protein kinase 2

Cat.:

U1852r

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96T

Polyclonal Antibody for Mouse Rho-associated protein kinase 2

Cat.:

P1852Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse Rho-associated protein kinase 2

Cat.:

P1852Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Rho-associated protein kinase 2

Cat.:

P1852Rb-h

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40ug/0.2ml

Monoclonal Antibody for Mouse Rho-associated protein kinase 2

Protein for Mouse Rho-associated protein kinase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"ROCK-I and ROCK-II, two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice."
Nakagawa O. , Fujisawa K. , Ishizaki T. , Saito Y. , Nakao K. , Narumiya S.
FEBS Lett.392:189-193(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
2.

"ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program."
Pelosi M. , Marampon F. , Zani B.M. , Prudente S. , Perlas E. , Caputo V. , Cianetti L. , Berno V. , Narumiya S. , Kang S.W. , Musaro A. , Rosenthal N.
Mol. Cell. Biol.27:6163-6176(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1144 (ISOFORM 2);PHOSPHORYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: C57BL/6J.
3.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 633-1388 AND 677-1388
strain: C57BL/6J.
tissue: Brain.
tissue: Urinary bladder.
4.

"Targeted disruption of the mouse rho-associated kinase 2 gene results in intrauterine growth retardation and fetal death."
Thumkeo D. , Keel J. , Ishizaki T. , Hirose M. , Nonomura K. , Oshima H. , Oshima M. , Taketo M.M. , Narumiya S.
Mol. Cell. Biol.23:5043-5055(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
5.

"ROCK-I regulates closure of the eyelids and ventral body wall by inducing assembly of actomyosin bundles."
Shimizu Y. , Thumkeo D. , Keel J. , Ishizaki T. , Oshima H. , Oshima M. , Noda Y. , Matsumura F. , Taketo M.M. , Narumiya S.
J. Cell Biol.168:941-953(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
6.

"Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner."
Sebbagh M. , Hamelin J. , Bertoglio J. , Solary E. , Breard J.
J. Exp. Med.201:465-471(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CLEAVAGE BY GRANZYME B
7.

"Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis."
Kroll J. , Epting D. , Kern K. , Dietz C.T. , Feng Y. , Hammes H.P. , Wieland T. , Augustin H.G.
Am. J. Physiol.296:H893-H899(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"A critical role of Rho-kinase ROCK2 in the regulation of spine and synaptic function."
Zhou Z. , Meng Y. , Asrar S. , Todorovski Z. , Jia Z.
Neuropharmacology56:81-89(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
9.

"Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice."
Biswas P.S. , Gupta S. , Chang E. , Song L. , Stirzaker R.A. , Liao J.K. , Bhagat G. , Pernis A.B.
J. Clin. Invest.120:3280-3295(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility."
Saito T. , Hirano M. , Ide T. , Ichiki T. , Koibuchi N. , Sunagawa K. , Hirano K.
Circulation127:104-114(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION

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