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Index > Protein center > ROR2(Gene name) > Human
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  • ROR2 (Gene name),
  • Tyrosine-protein kinase transmembrane receptor ROR2 (Protein name ),  ROR2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ROR2(NTRKR2);
    Protein name:
    Tyrosine-protein kinase transmembrane receptor ROR2;
    Alternative:
    Neurotrophic tyrosine kinase, receptor-related 2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; promotes osteogenesis. Binds YWHAB.
    Function:
    Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    943
    Sequence:
    50:
    MARGSALPRR | PLLCIPAVWA | AAALLLSVSR | TSGEVEVLDP | NDPLGPLDGQ | 
    100:
    DGPIPTLKGY | FLNFLEPVNN | ITIVQGQTAI | LHCKVAGNPP | PNVRWLKNDA | 
    150:
    PVVQEPRRII | IRKTEYGSRL | RIQDLDTTDT | GYYQCVATNG | MKTITATGVL | 
    200:
    FVRLGPTHSP | NHNFQDDYHE | DGFCQPYRGI | ACARFIGNRT | IYVDSLQMQG | 
    250:
    EIENRITAAF | TMIGTSTHLS | DQCSQFAIPS | FCHFVFPLCD | ARSRTPKPRE | 
    300:
    LCRDECEVLE | SDLCRQEYTI | ARSNPLILMR | LQLPKCEALP | MPESPDAANC | 
    350:
    MRIGIPAERL | GRYHQCYNGS | GMDYRGTAST | TKSGHQCQPW | ALQHPHSHHL | 
    400:
    SSTDFPELGG | GHAYCRNPGG | QMEGPWCFTQ | NKNVRMELCD | VPSCSPRDSS | 
    450:
    KMGILYILVP | SIAIPLVIAC | LFFLVCMCRN | KQKASASTPQ | RRQLMASPSQ | 
    500:
    DMEMPLINQH | KQAKLKEISL | SAVRFMEELG | EDRFGKVYKG | HLFGPAPGEQ | 
    550:
    TQAVAIKTLK | DKAEGPLREE | FRHEAMLRAR | LQHPNVVCLL | GVVTKDQPLS | 
    600:
    MIFSYCSHGD | LHEFLVMRSP | HSDVGSTDDD | RTVKSALEPP | DFVHLVAQIA | 
    650:
    AGMEYLSSHH | VVHKDLATRN | VLVYDKLNVK | ISDLGLFREV | YAADYYKLLG | 
    700:
    NSLLPIRWMA | PEAIMYGKFS | IDSDIWSYGV | VLWEVFSYGL | QPYCGYSNQD | 
    750:
    VVEMIRNRQV | LPCPDDCPAW | VYALMIECWN | EFPSRRPRFK | DIHSRLRAWG | 
    800:
    NLSNYNSSAQ | TSGASNTTQT | SSLSTSPVSN | VSNARYVGPK | QKAPPFPQPQ | 
    850:
    FIPMKGQIRP | MVPPPQLYVP | VNGYQPVPAY | GAYLPNFYPV | QIPMQMAPQQ | 
    900:
    VPPQMVPKPS | SHHSGSGSTS | TGYVTTAPSN | TSMADRAALL | SEGADDTQNA | 
    943:
    PEDGAQSTVQ | EAEEEEEGSV | PETELLGDCD | TLQVDEAQVQ | LEA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    SMR:
    String:
    MIM:
    UniGene:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Tyrosine-protein kinase transmembrane receptor ROR2
    ELISA Kit for Human Tyrosine-protein kinase transmembrane receptor ROR2
    CLIA Kit for Human Tyrosine-protein kinase transmembrane receptor ROR2
    CLIA Kit for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Polyclonal Antibody for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Polyclonal Antibody for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Monoclonal Antibody for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Monoclonal Antibody for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Protein for Human Tyrosine-protein kinase transmembrane receptor ROR2
    Protein for Human Tyrosine-protein kinase transmembrane receptor ROR2

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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A novel family of cell surface receptors with tyrosine kinase-like domain."
      Masiakowski P. , Carroll R.D.
      J. Biol. Chem.267:26181-26190(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-245
    2. 2.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 33-943;VARIANTS ALA-245 AND ILE-819
      tissue: Brain.
    4. 4.
      "Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B."
      Oldridge M. , Fortuna A.M. , Maringa M. , Propping P. , Mansour S. , Pollitt C. , DeChiara T.M. , Kimble R.B. , Valenzuela D.M. , Yancopoulos G.D. , Wilkie A.O.M.
      Nat. Genet.24:275-278(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-943;VARIANTS ALA-245 AND ILE-819
    5. 5.
      "Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B."
      Schwabe G.C. , Tinschert S. , Buschow C. , Meinecke P. , Wolff G. , Gillessen-Kaesbach G. , Oldridge M. , Wilkie A.O.M. , Koemec R. , Mundlos S.
      Am. J. Hum. Genet.67:822-831(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-574;VARIANT ALA-245
    6. 6.
      "O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes."
      Medzihradszky K.F. , Darula Z. , Perlson E. , Fainzilber M. , Chalkley R.J. , Ball H. , Greenbaum D. , Bogyo M. , Tyson D.R. , Bradshaw R.A. , Burlingame A.L.
      Mol. Cell. Proteomics3:429-440(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 465-474;SULFATION AT SER-469 AND SER-471;IDENTIFICATION BY MASS SPECTROMETRY
    7. 7.
      "Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation."
      Liu Y. , Ross J.F. , Bodine P.V.N. , Billiard J.
      Mol. Endocrinol.21:3050-3061(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH YWHAB;FUNCTION IN YWHAB PHOSPHORYLATION;DIMERIZATION;IDENTIFICATION BY MASS SPECTROMETRY
    8. 8.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2."
      Afzal A.R. , Rajab A. , Fenske C.D. , Oldridge M. , Elanko N. , Ternes-Pereira E. , Tueysuez B. , Murday V.A. , Patton M.A. , Wilkie A.O.M. , Jeffery S.
      Nat. Genet.25:419-422(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS RRS CYS-184; TRP-189; TRP-366 AND LYS-620
    10. 10.
      "Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome."
      van Bokhoven H. , Celli J. , Kayserili H. , van Beusekom E. , Balci S. , Brussel W. , Skovby F. , Kerr B. , Percin E.F. , Akarsu N. , Brunner H.G.
      Nat. Genet.25:423-426(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT RRS TYR-182
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    12. 12.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLN-244; ALA-245; ASP-349; ALA-490; GLN-530; MET-542; SER-548; LEU-557; ASN-644; ASN-672; ARG-695; CYS-738; LEU-762; ILE-819 AND GLU-935
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