SNRPB ELISA Kit for Human(Homo sapiens) | EIAab.comSNRPB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > SNRPB(Gene name) > Human

SNRPB (Gene name),

Small nuclear ribonucleoprotein-associated proteins B and B' (Protein name ), RSMB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

SNRPB(COD;SNRPB1);

Protein name:

Small nuclear ribonucleoprotein-associated proteins B and B'(snRNP-B);

Alternative:

Sm protein B/B'(Sm-B/B';SmB/B');

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Component of the heptameric ring U7 snRNP complex, or U7 Sm protein core complex, at least composed of LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF, SNRPG and U7 snRNA. Formation of the U7 snRNP is an ATP-dependent process mediated by a specialized SMN complex containing at least the Sm protein core complex and additionally, the U7-specific LSM10 and LSM11 proteins. Identified in the spliceosome C complex. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Interacts with CLNS1A, DDX20, LSM11, TDRD3, SNUPN and SMN1.

Function:

Appears to function in the U7 snRNP complex that is involved in histone 3'-end processing. Associated with snRNP U1, U2, U4/U6 and U5. May have a functional role in the pre-mRNA splicing or in snRNP structure. Binds to the downstream cleavage product (DCP) of histone pre-mRNA in a U7 snRNP dependent manner.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

240

Sequence:

50:

100:

150:

200:

240:

PPMGIPPGRG | TPMGMPPPGM | RPPPPGMRGP | PPPGMRPPRP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.83753

STRING:

9606.ENSP00000412566

KEGG:

hsa:6628

Pfam:

PF01423

String:

P14678

SMR:

P14678

MIM:

182282

Uniprot:

P14678

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ELISA Kit for Human snRNP-B

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E15489h

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96T

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ELISA Kit for Human snRNP-B

Cat.:

E15489b

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96T

ELISA Kit for Human snRNP-B

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E15489r

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96T

ELISA Kit for Human snRNP-B

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E15489m

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96T

ELISA Kit for Human snRNP-B

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E15489c

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96T

CLIA Kit for Human snRNP-B

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U15489r

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96T

CLIA Kit for Human snRNP-B

Cat.:

U15489m

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Packing:

96T

CLIA Kit for Human snRNP-B

Cat.:

U15489b

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MSDS:

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96T

CLIA Kit for Human snRNP-B

Cat.:

U15489c

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96T

CLIA Kit for Human snRNP-B

Cat.:

U15489h

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96T

Polyclonal Antibody for Human snRNP-B

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P15489Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human snRNP-B

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P15489Rb-r

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Polyclonal Antibody for Human snRNP-B

Cat.:

P15489Rb-m

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Monoclonal Antibody for Human snRNP-B

Protein for Human snRNP-B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloned human snRNP proteins B and B' differ only in their carboxy-terminal part."
van Dam A. , Winkel I. , Zijlstra-Baalbergen J. , Smeenk R. , Cuypers H.T.
EMBO J.8:3853-3860(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SM-B AND SM-B')
2.

"A comparison of snRNP-associated Sm-autoantigens: human N, rat N and human B/B'."
Schmauss C. , McAllister G. , Ohosone Y. , Hardin J.A. , Lerner M.R.
Nucleic Acids Res.17:1733-1743(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SM-B)
tissue: Thyroid carcinoma.
3.

Schmauss C. , McAllister G. , Ohosone Y. , Hardin J.A. , Lerner M.R.
Nucleic Acids Res.17:6777-6777(1989)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
4.

"Molecular cloning of cDNA encoding Sm autoantigen: derivation of a cDNA for a B polypeptide of the U series of small nuclear ribonucleoprotein particles."
Ohosone Y. , Mimori T. , Griffith A. , Akizuki M. , Homma M. , Craft J. , Hardin J.A.
Proc. Natl. Acad. Sci. U.S.A.86:4249-4253(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SM-B1)
tissue: Fibroblast.
5.

"Concerted regulation and molecular evolution of the duplicated SNRPB'/B and SNRPN loci."
Gray T.A. , Smithwick M.J. , Schaldach M.A. , Martone D.L. , Graves J.A. , McCarrey J.R. , Nicholls R.D.
Nucleic Acids Res.27:4577-4584(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM SM-B')
7.

"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"Epitope mapping of recombinant HeLa SmB and B' peptides obtained by the polymerase chain reaction."
Elkon K.B. , Hines J.J. , Chu J.-L. , Parnassa A.
J. Immunol.145:636-643(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-240 (ISOFORMS SM-B AND SM-B')
10.

Bienvenut W.V. , Lilla S. , von Kriegsheim A. , Lempens A. , Kolch W.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 9-16; 19-32 AND 66-147;METHYLATION AT ARG-108; ARG-112 AND ARG-147;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Ovarian carcinoma.
11.

"The small nuclear ribonucleoproteins, SmB and B', are products of a single gene."
Chu J.-L. , Elkon K.B.
Gene97:311-312(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 209-240
12.

"Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein."
Pillai R.S. , Will C.L. , Luehrmann R. , Schuemperli D. , Mueller B.
EMBO J.20:5470-5479(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE U7 SNRNP COMPLEX
13.

"SMN, the spinal muscular atrophy protein, forms a pre-import snRNP complex with snurportin1 and importin beta."
Narayanan U. , Ospina J.K. , Frey M.R. , Hebert M.D. , Matera A.G.
Hum. Mol. Genet.11:1785-1795(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDX20; SNUPN AND SMN1
14.

"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S. , Licklider L.J. , Gygi S.P. , Grigorieff N. , Moore M.J.
RNA8:426-439(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX
15.

"Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing."
Pillai R.S. , Grimmler M. , Meister G. , Will C.L. , Luehrmann R. , Fischer U. , Schuemperli D.
Genes Dev.17:2321-2333(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LSM11
tissue: Cervix carcinoma.
16.

"The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome."
Will C.L. , Schneider C. , Hossbach M. , Urlaub H. , Rauhut R. , Elbashir S. , Tuschl T. , Luehrmann R.
RNA10:929-941(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH THE U11/U12 SPLICEOSOME;IDENTIFICATION BY MASS SPECTROMETRY
17.

"Tudor domains bind symmetrical dimethylated arginines."
Cote J. , Richard S.
J. Biol. Chem.280:28476-28483(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TDRD3
18.

"Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes."
Azzouz T.N. , Pillai R.S. , Dapp C. , Chari A. , Meister G. , Kambach C. , Fischer U. , Schuemperli D.
J. Biol. Chem.280:34435-34440(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLNS1A AND SMN;METHYLATION
19.

"An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs."
Chari A. , Golas M.M. , Klingenhager M. , Neuenkirchen N. , Sander B. , Englbrecht C. , Sickmann A. , Stark H. , Fischer U.
Cell135:497-509(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SNRNP BIOGENESIS;IDENTIFICATION IN 6S PICLN-SM COMPLEX;IDENTIFICATION IN SMN-SM COMPLEX;SUBCELLULAR LOCATION
20.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.

"Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs."
Kambach C. , Walke S. , Young R. , Avis J.M. , de la Fortelle E. , Raker V.A. , Luehrmann R. , Li J. , Nagai K.
Cell96:375-387(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
22.

"Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution."
Pomeranz Krummel D.A. , Oubridge C. , Leung A.K. , Li J. , Nagai K.
Nature458:475-480(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (5.49 ANGSTROMS) OF 1-174 IN SPLICEOSOMAL U1 SNRNP
23.

"Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis."
Leung A.K. , Nagai K. , Li J.
Nature473:536-539(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.60 ANGSTROMS) OF 1-95 IN SPLICEOSOMAL CORE U4 SNRNP

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