Slc22a8 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSlc22a8 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Slc22a8(Gene name) > Rat

Slc22a8 (Gene name),

Solute carrier family 22 member 8 (Protein name ), S22A8_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Slc22a8(Oat3);

Protein name:

Solute carrier family 22 member 8;

Alternative:

Organic anion transporter 3(rOat3);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

N/A

Function:

Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Functions as one of the detoxification systems on the choroid plexus (CP) by removing substrates from the cerebrospinal fluid (CSF). Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient. Mediates the uptake from brain of organic anions, such as p-aminohippurate (PAH), ochratoxin A, and estrone sulfate (ES) and a cationic compound, cimetidine in a sodium independent manner. Mediates the uptake of benzylpenicillin (PCG), 2,4-dichloro-phenoxyacetate (2,4-D) and PAH in CP. Mediates the efflux of PAH, pravastatin, pitavastatin and PCG from the cerebrum into the blood circulation across the blood-brain barrier (BBB). Involved in regulating the CSF concentration of H(2)-receptor antagonists at the CP. Mediates the renal uptake of indoxyl sulfate (IS), 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) pravastatin, PCG, dehydroepiandrosterone sulfate (DHEAS) and is partly involved in the renal uptake of temocaprilat and ES.

Subcellular Location:

Basolateral cell membrane Multi-pass membrane protein Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells.

Protein Attributes:

Sequence length:

536

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

536:

PETIEDIQNW | HKQVQKTKQE | SEAEKASQII | PLKTGG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00083

KEGG:

rno:83500

UniGene:

Rn.23348

String:

Q9R1U7

Uniprot:

Q9R1U7

FOR

ELISA Kit for Rat Solute carrier family 22 member 8

CLIA Kit for Rat Solute carrier family 22 member 8

Polyclonal Antibody for Rat Solute carrier family 22 member 8

Monoclonal Antibody for Rat Solute carrier family 22 member 8

Protein for Rat Solute carrier family 22 member 8

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain."
Kusuhara H. , Sekine T. , Utsunomiya-Tate N. , Tsuda M. , Kojima R. , Cha S.H. , Sugiyama Y. , Kanai Y. , Endou H.
J. Biol. Chem.274:13675-13680(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY
strain: Sprague-Dawley.
tissue: Brain.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
3.

"Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus."
Nagata Y. , Kusuhara H. , Endou H. , Sugiyama Y.
Mol. Pharmacol.61:982-988(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
4.

"Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions."
Hasegawa M. , Kusuhara H. , Sugiyama D. , Ito K. , Ueda S. , Endou H. , Sugiyama Y.
J. Pharmacol. Exp. Ther.300:746-753(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
5.

"Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat."
Hasegawa M. , Kusuhara H. , Endou H. , Sugiyama Y.
J. Pharmacol. Exp. Ther.305:1087-1097(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier."
Kikuchi R. , Kusuhara H. , Sugiyama D. , Sugiyama Y.
J. Pharmacol. Exp. Ther.306:51-58(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient."
Sweet D.H. , Chan L.M. , Walden R. , Yang X.-P. , Miller D.S. , Pritchard J.B.
Am. J. Physiol.284:F763-F769(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
8.

"Involvement of multiple transporters in the efflux of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors across the blood-brain barrier."
Kikuchi R. , Kusuhara H. , Abe T. , Endou H. , Sugiyama Y.
J. Pharmacol. Exp. Ther.311:1147-1153(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3."
Nagata Y. , Kusuhara H. , Hirono S. , Endou H. , Sugiyama Y.
Drug Metab. Dispos.32:1040-1047(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus."
Nagata Y. , Kusuhara H. , Imaoka T. , Endou H. , Sugiyama Y.
J. Pharm. Sci.93:2724-2732(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
11.

"Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats."
Deguchi T. , Kouno Y. , Terasaki T. , Takadate A. , Otagiri M.
Pharm. Res.22:619-627(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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