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Index > Protein center > Slc5a12(Gene name) > Mouse
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  • Slc5a12 (Gene name),
  • Sodium-coupled monocarboxylate transporter 2 (Protein name ),  SC5AC_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Slc5a12(Smct2);
    Protein name:
    Sodium-coupled monocarboxylate transporter 2;
    Alternative:
    Low-affinity sodium-lactate cotransporter;Electroneutral sodium monocarboxylate cotransporter;Solute carrier family 5 member 12;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate.
    Subcellular Location:
    Apical cell membrane Multi-pass membrane protein Detected at the brush border membrane of the kidney. Colocalizes with vimentin in Mueller cells.
    Protein Attributes:
    Sequence length:
    619
    Sequence:
    50:
    MRVKNFEAWD | YVVFAGLFVI | SSGIGVFFAI | KERKKTTSRE | FLVGGRQMSF | 
    100:
    GPVALSLTAS | FMSAVTVLGT | PAEVYRFGAS | FFLFLISYVF | VVFFTSELFL | 
    150:
    PVFYRSGITS | TYEYLQLRFN | KPVRYAATII | YIVQTILYTG | VVVYAPALAL | 
    200:
    NQVTGFNLWA | SVFATGIVCT | FYCSLGGLKA | VVWTDAFQMV | VMIVGFLTVL | 
    250:
    IQGSNHVGGF | NNVLEKAGNG | SRLHIVDFDV | DPLRRHTFWT | ITIGGTFTWL | 
    300:
    GVYGVNQSTI | QRCISCKTEK | HAKLALYFNL | LGLWIIVACA | VFSGLIMYSH | 
    350:
    FKDCDPWTSG | VISAPDQLMP | YFVMEIFATM | PGLPGLFVAC | AFSGTLSTVA | 
    400:
    ASINALATVT | FEDFVKSCFP | HLSDKLSTWI | SKGLCILFGI | MCTSMAVVAS | 
    450:
    LMGSVVQAAL | SIHGMCGGPM | LGLFTLGLVF | PFVNWKGALG | GLLTGITLSF | 
    500:
    WVAIGSFIYP | APESKTLPLP | LSTEHCVELN | ITTTVAPQIS | SRPVLADTWY | 
    550:
    SLSYLYFSAV | GCLGCIAAGI | IISFLTGKQR | GKDIDPLLIR | PVCNLFCFWS | 
    600:
    KKYKTLCWCG | VQHDRETEQD | YLDSGSAWKQ | GVESGLQNGL | KQDTLAQIPG | 
    619:
    YNPKEKSYSN | SVPEKTTYF
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    ELISA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    ELISA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    CLIA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    CLIA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    CLIA Kit for Mouse Sodium-coupled monocarboxylate transporter 2
    Polyclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Polyclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Polyclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Monoclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Monoclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Monoclonal Antibody for Mouse Sodium-coupled monocarboxylate transporter 2
    Protein for Mouse Sodium-coupled monocarboxylate transporter 2
    Protein for Mouse Sodium-coupled monocarboxylate transporter 2
    Protein for Mouse Sodium-coupled monocarboxylate transporter 2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2)."
      Srinivas S.R. , Gopal E. , Zhuang L. , Itagaki S. , Martin P.M. , Fei Y.-J. , Ganapathy V. , Prasad P.D.
      Biochem. J.392:655-664(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;STOICHIOMETRY;TISSUE SPECIFICITY
      strain: C57BL/6.
      tissue: Kidney.
    2. 2.
      "Sequence of a novel sodium solute cotransporter similar to the Na-iodide transporter."
      Mount D.B.
      Submitted (2002-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: C57BL/6.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Kidney.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-619 (ISOFORM 1)
    6. 6.
      "c/ebpdelta null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney."
      Thangaraju M. , Ananth S. , Martin P.M. , Roon P. , Smith S.B. , Sterneck E. , Prasad P.D. , Ganapathy V.
      J. Biol. Chem.281:26769-26773(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INDUCTION;TISSUE SPECIFICITY
    7. 7.
      "Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney."
      Gopal E. , Umapathy N.S. , Martin P.M. , Ananth S. , Gnana-Prakasam J.P. , Becker H. , Wagner C.A. , Ganapathy V. , Prasad P.D.
      Biochim. Biophys. Acta1768:2690-2697(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina."
      Martin P.M. , Dun Y. , Mysona B. , Ananth S. , Roon P. , Smith S.B. , Ganapathy V.
      Invest. Ophthalmol. Vis. Sci.48:3356-3363(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION;TISSUE SPECIFICITY
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